A biochemical function for attractin in agouti-induced pigmentation and obesity

Nature Genetics

Volumn 27, Issue 1, 2001, Pages 40-47

  He, Lin ^a   Gunn, Teresa M ^a   Bouley, Donna M ^a   Lu, Xin Yun ^b   Watson, Stanley J ^b   Schlossman, Stuart F ^c   Duke Cohan, Jonathan S ^c   Barsh, Gregory S ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; COMPLEMENTARY DNA; MESSENGER RNA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; EVOLUTION; GENE MUTATION; GENOME; GENOTYPE; HISTOPATHOLOGY; MOUSE; NONHUMAN; OBESITY; PIGMENTATION; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; CENTRAL NERVOUS SYSTEM; CLONING, MOLECULAR; CONSERVED SEQUENCE; EPISTASIS, GENETIC; EVOLUTION, MOLECULAR; GENETIC COMPLEMENTATION TEST; GENOTYPE; GLYCOPROTEINS; HAIR COLOR; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; OBESITY; PEPTIDE FRAGMENTS; PIGMENTATION; PROTEIN BINDING; PROTEINS; RNA, MESSENGER; SEQUENCE ALIGNMENT; SURFACE PLASMON RESONANCE; TRANSGENES;

AGOUTI; ANIMALIA; MUS MUSCULUS; SWIETENIA;

EID: 0035167085     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/83741     Document Type: Article

References (50)

1. Molecular and developmental genetics of mouse coat color
2. Expression and transgenic studies of the mouse agouti gene provide insight into the mechanisms by which mammalian coat color patterns are generated
3. Agouti structure and function: Characterization of a potent α-melanocyte stimulating hormone receptor antagonist
4. A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation
5. Pleiotropic effects of the mouse lethal yellow (A(y)) mutation explained by deletion of a maternally expressed gene and the simultaneous production of agouti fusion RNAs
6. Central nervous system control of food intake
7. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice
8. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
9. The melanocortin receptors: Agonists, antagonists, and the hormonal control of pigmentation
10. Biochemical, biophysical, and pharmacological characterization of bacterially expressed human agouti-related protein
11. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
12. Effects of recombinant agouti-signaling protein on melanocortin action
13. Characterization of Agouti-related protein binding to melanocortin receptors
14. Overexpression of Agrt leads to obesity in transgenic mice
15. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function
16. Targeted disruption of the melanocortin-4 receptor results in obesity in mice
17. Mahogany, a recessive color mutation in linkage group V of the mouse
18. Genetic studies of the mouse mutations mahogany and mahoganoid
19. Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions
20. The mouse mahogany locus encodes a transmembrane form of human attractin
21. The mahogany protein is a receptor involved in suppression of obesity
22. Secreted and membrane attractin result from alternative splicing of the human ATRN gene
23. Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo
24. Agouti and agouti-related protein: Analogies and contrasts
25. Mahogany (mg) stimulates feeding and increases basal metabolic rate independent of its suppression of agouti
26. Distribution of mahogany/attractin mRNA in the rat central nervous system
27. Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice
28. Activation of the receptor tyrosine kinase Kit is required for the proliferation of melanoblasts in the mouse embryo
29. Coupled site-directed mutagenesis/transgenesis identifies important functional domains of the mouse agouti protein
30. Overexpression of an Agouti cDNA in the skin of transgenic mice recapitulates dominant coat color phenotypes of spontaneous mutants
31. Mutations in the carboxyl terminus of the agouti protein decrease agouti inhibition of ligand binding to the melanocortin receptors
32. The mahogany mouse mutation: Further links between pigmentation, obesity and the immune system
33. The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor Fit-1
34. A requirement for neuropilin-1 in embryonic vessel formation
35. The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila
36. Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs
37. Isolation and sequencing of insecticidal peptides from the primitive hunting spider, Plectreurys tristis (Simon)
38. Widespread expression of Agouti-related protein (AGRP) in the chicken: A possible involvement of AGRP in regulating peripheral melanocortin systems in the chicken
39. Neuropilin is a receptor for the axonal chemorepellent Semaphorin II1
40. Determination of cell adhesion sites of neuropilin-1
41. The occurence of three recognized color mutations in mice
42. DK/Lm: A strain of laboratory mouse with an unusual expression of the lethal yellow (Ay) phenotype
43. Quantitative trait loci that modify the sootiness of yellow pigmentation in KK-A(y)/a mice
44. Genome-wide, large-scale production of mutant mice by ENU mutagenesis
45. Infection of eucaryotic cells by helper-independent recombinant adenoviruses: Early region 1 is not obligatory for integration of viral DNA
46. A human β-actin expression vector system directs high-level accumulation of antisense transcripts
47. A novel form of dipeptidylpeptidase IV found in human serum. Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26)
48. Down-regulation of melanocortin receptor signaling mediated by the amino terminus of Agouti protein in Xenopus melanophores
49. Attractin/Mahogany/Zitter plays a critical role in myelination of the central nervous system