Mutations in the carboxyl terminus of the agouti protein decrease agouti inhibition of ligand binding to the melanocortin receptors

Biochemistry

Volumn 36, Issue 8, 1997, Pages 2084-2090

  Kiefer, Laura L ^a   Ittoop, Olivia R R ^a   Bunce, Keith ^b   Truesdale, Anne T ^a   Willard, Derril H ^a   Nichols, James S ^a   Blanchard, Steven G ^a   Mountjoy, Kathleen ^c   Chen, Wen Ji ^a   Wilkison, William O ^a  

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; GENE EXPRESSION; HYPERINSULINEMIA; LIGAND BINDING; LIPOLYSIS; MOUSE; NONHUMAN; OBESITY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PURIFICATION; SITE DIRECTED MUTAGENESIS; STEROIDOGENESIS; THERMOREGULATION;

ANIMALS; CELL LINE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MICE; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEINS; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTORS, CORTICOTROPIN; RECEPTORS, MELANOCORTIN; SIGNAL TRANSDUCTION;

EID: 0031042075     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi962647v     Document Type: Article

References (35)

1. Blanchard, S. G., Harris, C. O., Ittoop, O., Nichols, J. S., Parks, D. J., Truesdale, A. T., & Wilkison, W. O. (1995) Biochemistry 34, 10406-10411.
2. Boston, B. A., & Cone, R. D. (1996) Endocrinology 137, 2043-2050.
3. Bultman, S. J., Michaud, E. J., & Woychik, R. P. (1992) Cell 71, 1195-1204.
4. Chen, C., & Okayama, H. (1987) Mol. Cell. Biol. 7, 2745-2752.
5. Cheng, Y., & Prusoff, W. H. (1973) Biochem. Pharmacol. 22, 3099.
6. Chhajlani, V., & Wikberg, J. E. S. (1992) FEBS Lett. 309, 417-420.
7. Chretien, M. (1974) Triangle 13, 63-71.
8. Desarnaud, F., Labbe, O., Eggerickx, D., Vassart, G., & Parmentier, M. (1994) Biochem. J. 299, 367-373.
9. Di Wied, D., & Jolles, J. (1982) Physiol. Rev. 62, 976-1059.
10. Gantz, I., Konda, Y., Tashiro, T., Shimoto, Y., Miwa, H., Munzert, G., Watson, S. J., DelValle, J., & Yamada, T. (1993a) J. Biol. Chem. 268, 8246-8250.
11. Gantz, I., Miwa, H., Konda, Y., Shimoto, Y., Tashiro, T., Watson, S. J., DelValle, J., & Yamada, T. (1993b) J. Biol. Chem. 268, 15174-15179.
12. Klebig, M. L., Wilkinson, J. E., Geisler, J. G., & Woychik, R. P. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 4728-4732.
13. Kwon, H. Y., Bultman, S. J., Loffler, C., Chen, W.-J., Furdon, P. J., Powell, J. G., Usala, A.-L., Wilkison, W. O., Hansmann, I., & Woychik, R. P. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 9760-9764.
14. Labbe, O., Desarnaud, F., Eggerickx, D., Vassart, G., & Parmentier, M. (1994) Biochemistry 33, 4543-4549.
15. Lamoreux, M. L. (1973) Doctoral dissertation, The Jackson Laboratory, Bar Harbor, ME.
16. Low, M. J., Simerly, R. B., & Cone, R. D. (1994) Curr. Opin. Endocrinol. Diabetes 79-88.
17. Lu, D., Willard, D., Patel, I. R., Kadwell, S., Overton, L., Kost, T., Luther, M., Chen, W., Woychik, R. P., Wilkison, W. O., & Cone, R. D. (1994) Nature 371, 799-802.
18. Luckow, V. A., Lee, S. C., Barry, G. F., & Olins, P. O. (1993) J. Virol. 67, 4566-4579.
19. Lunec, J., Pieron, C., Bal, W., MacNeil, S., & Thody, A. J. (1993) Melanoma Res. 3, 99-106.
20. Martin, S. M., Malkinson, T. J., Veale, W. L., & Pittman, Q. J. (1990) Brain Res. 526, 351-354.
21. Michaud, E. J., Bultman, S. J., Stubbs, L. J., & Woychik, R. P. (1993) Genes Dev. 7, 1203-1213.
22. Michaud, E. J., Bultman, S. J., Klebig, M. L., van Vugt, M. J., Stubbs, L. J., Rusell, L. B., & Woychik, R. P. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 2562-2566.
23. Mountjoy, K. G., Robbins, L. S., Mortrud, M. T., & Cone, R. D. (1992) Science 257, 1248-1251.
24. Mountjoy, K. G., Mortund, M. T., Low, M. J., Simerly, R. B., & Cone, R. D. (1994) Mol. Endocrinol. 8, 1298-1308.
25. Murphy, M. T., Richards, D. B., & Lipton, J. M. (1983) Science 221, 192-193.
26. O'Donohue, T. L., & Dorsa, D. M. (1982) Peptides 3, 353-395.
27. Ramachandran, J. (1987) in Hormonal Proteins and Peptides (Li, C. H., Ed.) Vol. XIII, pp 31 -57, Academic Press, Orlando, FL.
28. Robbins, L. S., Nadeau, J. H., Johnson, K. R., Kelly, M. A., Roselli-Rehfuss, L., Baack, E., Mountjoy, K. G., & Cone, R. D. (1993) Cell 72, 827-834.
29. Roselli-Rehfuss, L., Mountjoy, K. G., Robbins, L. S., Mortrud, M. T., Low, M. J., Tatro, J. B., Entwistle, M. L., Simerly, R. B., & Cone, R. D. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 8856-8860.
30. Schioth, H. B., Muceniece, R., Wikberg, J. E., & Chhajlani, V. (1995) Eur. J. Pharmacol. 288, 311-317.
31. Schioth, H. B., Muceniece, R., & Wikberg, J. E. S. (1996) Pharmacol. Toxicol. 79, 161-165.
32. Schwyzer, R., & Eberle, A. (1977) Front. Horm. Res. 4, 18-25.
33. Solca, F. F. A., Salomon, Y., & Eberle, A. N. (1991) J. Recept. Res. 11, 379-390.
34. Willard, D. H., Bodnar, W., Harris, C., Nichols, J., Kiefer, L. L., Hoffman, C., Moyer, M., Burkhart, W., Weiel, J., Wilkison, W. O., & Rocque, W. (1995) Biochemistry 34, 12341-12346.
35. Yen, T. T., Gill, A. M., Frigeri, L. G., Barsh, G. S., & Wolff, G. L. (1994) FASEB J. 8, 479-488.