Eukaryotic DNA replication: From pre-replication complex to initiation complex

Current Opinion in Cell Biology

Volumn 12, Issue 6, 2000, Pages 690-696

  Takisawa, Haruhiko ^a   Mimura, Satoru ^a   Kubota, Yumiko ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; DNA;

CHROMATIN; DNA REPLICATION; DNA SYNTHESIS; ENZYME ACTIVITY; EUKARYOTE; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; YEAST;

EID: 0033711454     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(00)00153-8     Document Type: Review

References (60)

1. First the CDKs, now the DDKs
2. Emerging mechanisms of eukaryotic DNA replication initiation
3. The regulation of replication origin activation
4. ATPase switches controlling DNA replication initiation
5. Replication origins in yeast versus metazoa: Separation of the haves and the have nots
6. Think global, act local - How to regulate S phase from individual replication origins
7. Two steps in the assembly of complexes at yeast replication origins in vivo
8. The Cdt1 protein is required to license DNA for replication in fission yeast
9. XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis
10. Cell cycle. A new check on issuing the licence
11. Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins
12. Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders
13. Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins
14. The cyclin-dependent kinase Cdc28p regulates distinct modes of Cdc6p proteolysis during the budding yeast cell cycle
15. The Cdc7 protein kinase is required for origin firing during S phase
16. Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2
17. Xenopus Cdc45-dependent loading of DNA polymerase onto chromatin under the control of S-phase Cdk
18. Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin
19. Central role for Cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts
20. Components and dynamics of DNA replication complexes in S. cerevisiae: Redistribution of MCM proteins and Cdc45p during S phase
21. Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication
22. Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent, kinases and Cdc7p-Dbf4p kinase
23. CDC45 is required in conjunction with CDC7/DBF4 to trigger the initiation of DNA replication
24. CDC7 kinase complex as a molecular switch for DNA replication
25. Cdk2-dependent and -independent pathways in E2F-mediated S phase induction
26. Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
27. Negative regulation of Cdc18 DNA replication protein by Cdc2
28. Cdc18 transcription and proteolysis couple S phase to passage through mitosis
29. G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus
30. Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7
31. Cyclin A-dependent kinase activity affects chromatin binding of ORC, Cdc6, and MCM in egg extracts of Xenopus laevis
32. Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2
33. Distinct phosphoisoforms of the Xenopus Mcm4 protein regulate the function of the Mcm complex
34. Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication
35. A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells
36. Xenopus Cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading
37. mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p
38. Premature structural changes at replication origins in a yeast minichromosome maintenance (MCM) mutant
39. A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication
40. Hierarchy of S-phase-promoting factors: Yeast Dbf4-cdc7 kinase requires prior S-phase cyclin-dependent kinase activation
41. Initiation of eukaryotic DNA replication: Origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha
42. Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases
43. Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha
44. Biochemical analysis of the intrinsic Mcm4-Mcm6-Mcm7 DNA helicase activity
45. Isolation and characterization of various complexes of the minichromosome maintenance proteins of Schizosaccharomyces pombe
46. The single minichromosome maintenance protein of Methanobacterium thermoautotrophicum ΔH contains DNA helicase activity
47. A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase
48. The intrinsic DNA helicase activity of Methanobacterium thermoautotrophicum ΔH minichromosome maintenance protein
49. Uninterrupted MCM2-7 function required for DNA replication fork progression
50. DNA synthesis at individual replication forks requires the essential initiation factor cdc45p
51. Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro
52. Dpb11 controls the association between DNA polymerases α and ε and the autonomously replicating sequence
53. DNA polymerase ε catalytic domains are dispensable for DNA replication, DNA repair, and cell viability
54. Analysis of the essential functions of the C-terminal protein/protein interaction domain of Saccharomyces cerevisiae pol e ε and its unexpected ability to support growth in the absence of the DNA polymerase domain
55. Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharornyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint
56. Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+
57. Sld2, which interacts with Dpb11 in Saccharornyces cerevisiae, is required for chromosomal DNA replication
58. DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae
59. The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins
60. A DNA unwinding factor involved in DNA replication in cell-free extracts of Xenopus eggs