A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication

Genes and Development

Volumn 13, Issue 16, 1999, Pages 2159-2176

  Pasero, Philippe ^a,b   Duncker, Bernard P ^a   Schwob, Etienne ^b   Gasser, Susan M ^a  

^a SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

^b CNRS   (France)

Author keywords

CDC28; CDC7; DBF4; DNA replication; S phase promoting factor

Indexed keywords

CDC7 KINASE; CESIUM CHLORIDE; DNA; PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL NUCLEUS; CHROMATIN; DNA REPLICATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; SPHEROPLAST; YEAST;

VERTEBRATA;

EID: 0033567357     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.13.16.2159     Document Type: Article

References (72)

1. Adachi, Y. and U.K. Laemmli. 1994. Study of the cell cycle-dependent assembly of the DNA pre-replication centres in Xenopus egg extracts. EMBO J. 13: 4153-4164.
2. Aparicio, O. M., D.M. Weinstein, and S.P. Bell. 1997. Components and dynamics of DNA replication complexes in S. cerevisiae: Redistribution of MCM proteins and Cdc45p during S phase. Cell 91: 59-69.
3. Bahman, M., V. Buck, A. White, and J. Rosamond. 1988. Characterisation of the CDC7 gene product of Saccharomyces cerevisiae as a protein kinase needed for the initiation of mitotic DNA synthesis. Biochim. Biophys. Acta 951:335-343.
4. Blow, J.J. 1996. Chromosome replication in Xenopus egg extracts. In Eukaryotic DNA replication (ed. J.J. Blow), pp. 143-165. IRL Press, Oxford, UK.
5. Bousset, K. and J.F. Diffley. 1998. The Cdc7 protein kinase is required for origin firing during S phase. Genes & Dev. 12: 480-490.
6. Braguglia, D., P. Heun, P. Pasero, B.P. Duncker, and S.M. Gasser. 1998. Semi-conservative replication in yeast nuclear extracts requires Dna2 helicase and supercoiled template. J. Mol. Biol. 281: 631-649.
7. Brewer, B.J., J.D. Diller, K.L. Friedman, K.M. Kolor, M.K. Raghuraman, and W.L. Fangman. 1993. The topography of chromosome replication in yeast. Cold Spring Harb. Symp. Quant. Biol. 58: 425-434.
8. Carpenter, P.B., P.R. Mueller, and W.G. Dunphy. 1996. Role for a Xenopus ORC2-related protein in controlling DNA replication. Nature 379: 357-360.
9. Chapman, J.W. and L.H. Johnston. 1989. The yeast gene, DBF4, essential for entry into S phase is cell cycle regulated. Exp. Cell. Res. 180: 419-428.
10. Cocker, J.H., S. Piatti, C. Santocanale, K. Nasmyth, and J.F. Diffley. 1996. An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast. Nature 379: 180-182.
11. Coleman, T.R., P.B. Carpenter, and W.G. Dunphy. 1996. The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell 87: 53-63.
12. Coverley, D. and R.A. Laskey. 1994. Regulation of eukaryotic DNA replication. Annu. Rev. Biochem. 63: 745-776.
13. Diffley, J.F. 1996. Once and only once upon a time: Specifying and regulating origins of DNA replication in eukaryotic cells. Genes & Dev. 10: 2819-2830.
14. Diffley, J.F., J.H. Cocker, S.J. Dowell, and A. Rowley. 1994. Two steps in the assembly of complexes at yeast replication origins in vivo. Cell 78: 303-316.
15. Dixon, W.J. and J.L. Campbell. 1997. Preparation of active Cdc7/Dbf4 kinase from yeast cells. Methods Enzymol. 283: 390-397.
16. Donaldson, A.D., W.L. Fangman, and B.J. Brewer. 1998a. Cdc7 is required throughout the yeast S phase to activate replication origins. Genes & Dev. 12: 491-501.
17. Donaldson, A.D., M.K. Raghuraman, K.L. Friedman, F.R. Cross, B.J. Brewer, and W.L. Fangman. 1998b. CLB5-dependent activation of late replication origins in S. cerevisiae. Mol. Cell 2:173-182.
18. Donovan, S., J. Harwood, L.S. Drury, and J.F. Diffley. 1997. Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc. Natl. Acad. Sci. 94: 5611-5616.
19. Dowell, S.J., P. Romanowski, and J.F. Diffley. 1994. Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. Science 265: 1243-1246.
20. Duncker, B.P., P. Pasero, D. Braguglia, P. Heun, M. Weinreich, and S.M. Gasser. 1999. Cyclin B-cdk1 kinase stimulates ORC-and Cdc6-independent steps of semiconservative plasmid replication in yeast nuclear extracts. Mol. Cell. Biol. 19: 1226-1241.
21. Dutta, A. and S.P. Bell. 1997. Initiation of DNA replication in eukaryotic cells. Annu. Rev. Cell Dev. Biol. 13: 293-332.
22. Fox, C.A., S. Loo, A. Dillin, and J. Rine. 1995. The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication. Genes & Dev. 9: 911-924.
23. Gotta, M., T. Laroche, A. Formenton, L. Maillet, H. Scherthan, and S.M. Gasser. 1996. The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae. J. Cell Biol. 134: 1349-1363.
24. Hardy, C.F. 1996. Characterization of an essential Orc2p-associated factor that plays a role in DNA replication. Mol. Cell. Biol. 16: 1832-1841.
25. Hardy, C.F. and A. Pautz. 1996. A novel role for Cdc5p in DNA replication. Mol. Cell. Biol. 16: 6775-6782.
26. Hardy, C.F., O. Dryga, S. Seematter, P.M. Pahl, and R.A. Sclafani. 1997. mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p. Proc. Natl. Acad. Sci. 94:3151-3155.
27. Hartwell, L.H. 1976. Sequential function of gene products relative to DNA synthesis in the yeast cell cycle. J. Mol. Biol. 104: 803-817.
28. Hartwell, L.H., J. Culotti, J.R. Pringle, and B.J. Reid. 1974. Genetic control of the cell division cycle in yeast. Science 183: 46-51.
29. Hennessy, K.M., A. Lee, E. Chen, and D. Botstein. 1991. A group of interacting yeast DNA replication genes. Genes & Dev. 5: 958-969.
30. Hereford, L.M. and L.H. Hartwell. 1974. Sequential gene function in the initiation of Saccharomyces cerevisiae DNA synthesis. J. Mol. Biol. 84: 445-461.
31. Hollingsworth, R.E. Jr. and R.A. Sclafani. 1990. DNA metabolism gene CDC7 from yeast encodes a serine (threonine) protein kinase. Proc. Natl. Acad. Sci. 87: 6272-6276.
32. Hua, X.H. and J. Newport. 1998. Identification of a preinitiation step in DNA replication that is independent of Origin Recognition Complex and Cdc6, but dependent on Cdk2. J. Cell Biol. 140: 271-281.
33. Jackson, A.L., P.M. Pahl, K. Harrison, J. Rosamond, and R.A. Sclafani. 1993. Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein. Mol. Cell. Biol. 13: 2899-2908.
34. Jallepalli, P.V. and T.J. Kelly. 1997. Cyclin-dependent kinase and initiation at eukaryotic origins: A replication switch? Curr. Opin. Cell. Biol. 9: 358-363.
35. Jiang, W. and T. Hunter. 1997. Identification and characterization of a human protein kinase related to budding yeast Cdc7p. Proc. Natl. Acad. Sci. 94: 14320-14325.
36. Karwan, R.M., T. Laroche, U. Wintersberger, S.M. Gasser, and M. Binder. 1990. Ribonuclease H(70) is a component of the yeast nuclear scaffold. J. Cell Sci. 96: 451-459.
37. Kitada, K., L.H. Johnston, T. Sugino, and A. Sugino. 1992. Temperature-sensitive cdc7 mutations of Saccharomyces cerevisiae are suppressed by the DBF4 gene, which is required for the G1/S cell cycle transition. Genetics 131: 21-29.
38. Krude, T., M. Jackman, J. Pines, and R.A. Laskey. 1997. Cyclin/ Cdk-dependent initiation of DNA replication in a human cell-free system. Cell 88: 109-119.
39. Lei, M., Y. Kawasaki, M.R. Young, M. Kihara, A. Sugino, and B.K. Tye. 1997. Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. Genes & Dev. 11: 3365-3374.
40. Liang, C. and B. Stillman. 1997. Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants. Genes & Dev. 11: 3375-3386.
41. Liang, C., M. Weinreich, and B. Stillman. 1995. ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome. Cell 81: 667-676.
42. Loo, S., C.A. Fox, J. Rine, R. Kobayashi, B. Stillman, and S. Bell. 1995. The origin recognition complex in silencing, cell cycle progression, and DNA replication. Mol. Biol. Cell. 6: 741-756.
43. Masai, H., T. Miyake, and K. Arai. 1995. hskl+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae Cdc7, is required for chromosomal replication. EMBO J. 14: 3094-3104.
44. Moreno, S., J. Hayles, and P. Nurse. 1989. Regulation of p34cdc2 protein kinase during mitosis. Cell 58: 361-372.
45. Newlon, C.S. 1997. Putting it all together: Building a prereplicative complex. Cell 91: 717-720.
46. Pasero, P. and S.M. Gasser. 1998. New systems for replicating DNA in vitro. Curr. Opin. Cell Biol. 10: 304-310.
47. Pasero, P., D. Braguglia, and S.M. Gasser. 1997. ORC-dependent and origin-specific initiation of DNA replication at defined foci in isolated yeast nuclei. Genes & Dev. 11: 1504-1518.
48. Pasero, P., B.P. Duncker, and S.M. Gasser. 1999. In vitro DNA replication in yeast nuclear extracts. Methods, Companion Methods Enzymol. (In press).
49. Piatti, S., C. Lengauer, and K. Nasmyth. 1995. Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae. EMBO J. 14: 3788-3799.
50. 1 defines a 'point of no return' after which Cdc6 synthesis cannot promote DNA replication in yeast. Genes & Dev. 10: 1516-1531.
51. Raghuraman, M.K., B.J. Brewer, and W.L. Fangman. 1997. Cell cycle-dependent establishment of a late replication program. Science 276: 806-809.
52. Rao, P.N. and R.T. Johnson. 1970. Mammalian cell fusion: Studies on the regulation of DNA synthesis and mitosis. Nature 225: 159-164.
53. Rose, M.D., F. Winston, and P. Hieter. 1990. Methods in yeast genetics Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
54. Rout, M.P. and G. Blobel. 1993. Isolation of the yeast nuclear pore complex. J. Cell Biol. 123: 771-783.
55. Santocanale, C. and J.F. Diffley. 1996, ORC-and Cdc6-dependent complexes at active and inactive chromosomal replication origins in S. cerevisiae. EMBO J. 15: 6671-6619.
56. _. 1998. Mec1-and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature 395: 615-618.
57. Sato, N., K. Arai, and H. Masai. 1997. Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: In vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. EMBO J. 16: 4340-4351.
58. Schwob, E. and K. Nasmyth. 1993. CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae. Genes & Dev. 7: 1160-1175.
59. _. 1996. Cell cycle control of DNA replication in Saccharomyces cerevisiae. In Eukaryotic DNA replication (ed. J.J. Blow), pp. 165-197. IRL Press Oxford, UK.
60. Schwob, E., T. Bohm, M.D. Mendenhall, and K. Nasmyth. 1994. The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79: 233-244.
61. Sclafani, R.A. and A.L. Jackson. 1994. Cdc7 protein kinase for DNA metabolism comes of age. Mol. Microbiol. 11: 805-810.
62. Sclafani, R.A., M. Patterson, J. Rosamond, and W.L. Fangman. 1988. Differential regulation of the yeast CDC7 gene during mitosis and meiosis. Mol. Cell. Biol. 8: 293-300.
63. Shen, S.H., P. Chretien, L. Bastien, and S.N. Slilaty. 1991. Primary sequence of the glucanase gene from Oerskovia xanthineolytica. Expression and purification of the enzyme from Escherichia coli. J. Biol. Chem. 266: 1058-1063.
64. Tanaka T. and K. Nasmyth. 1998. Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin-and Dbf4-dependent kinases. EMBO J. 17: 5182-5191.
65. Tanaka, T., D. Knapp, and K. Nasmyth. 1997. Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs. Cell 90: 649-660.
66. Verma, R., R.M. Feldman, and R.J. Deshaies. 1997. SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities. Mol. Biol. Cell 8: 1427-1437.
67. Walter, J., L. Sun, and J. Newport. 1998. Regulated chromosomal DNA replication in the absence of a nucleus. Mol. Cell 1: 519-529.
68. Weinert, T., G.L. Kiser, and L.H. Hartwell. 1994. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes & Dev. 8: 652-665.
69. Yan, H., S. Gibson, and B.K. Tye. 1991. Mcm2 and Mcm3, two proteins important for ARS activity, are related in structure and function. Genes & Dev. 5: 944-957.
70. Yoon, H.J. and J.L. Campbell. 1991. The CDC7 protein of S. cerevisiae is a phosphoprotein that contains protein kinase activity. Proc. Natl. Acad. Sci. 88: 3574-3578.
71. Yoon, H.J., S. Loo, and J.L. Campbell. 1993. Regulation of S. cerevisiae CDC7 function during the cell cycle. Mol. Biol. Cell. 4: 195-208.
72. Zou, L. and B. Stillman. 1998. Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin. Science 280: 593-596.