Triggering ubiquitination of a CDK inhibitor at origins of DNA replication

Nature Cell Biology

Volumn 3, Issue 8, 2001, Pages 715-722

  Furstenthal, Laura ^a   Swanson, Craig ^a   Kaiser, Brett K ^a   Eldridge, Adam G ^a   Jackson, Peter K ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CHROMOSOME PROTEIN; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN E; DNA; GEMININ; HOMEODOMAIN PROTEIN; INITIATION FACTOR; LIGASE; NUCLEAR PROTEIN; PROTEIN P21; PROTEIN P27; PROTEIN P57; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE PARAMETERS; CELL CYCLE S PHASE; CELL NUCLEUS; CHROMATIN; CHROMOSOME; COMPLEX FORMATION; CONTROLLED STUDY; DNA REPLICATION ORIGIN; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN FAMILY; XENOPUS;

ANIMALS; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; CDC2-CDC28 KINASES; CELL CYCLE; CELL CYCLE PROTEINS; CHROMATIN; CHROMOSOMAL PROTEINS, NON-HISTONE; CULLIN PROTEINS; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; DNA REPLICATION; DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; EMBRYO; FEMALE; LIGASES; NUCLEAR PROTEINS; OOCYTES; ORIGIN RECOGNITION COMPLEX; PEPTIDE HYDROLASES; PEPTIDE SYNTHASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; S-PHASE KINASE-ASSOCIATED PROTEINS; SKP CULLIN F-BOX PROTEIN LIGASES; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINS; XENOPUS LAEVIS; XENOPUS PROTEINS;

ANIMALIA;

EID: 0034906905     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/35087026     Document Type: Article

References (51)

1. The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. Cerevisiae
2. SCF and Cullin/Ring H2-based ubiquitin ligases
3. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
4. Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation
5. Targeted disruption of skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication
6. P45Skp2 promotes p27Kip1 degradation and induces S phase in quiescent cells
7. Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins
8. Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination
9. A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p
10. Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase
11. Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle
12. Proteolysis and DNA replication: The CDC34 requirement in the Xenopus egg cell cycle
13. Cell cycle control by Xenopus p28Kix1, a developmentally regulated inhibitor of cyclin-dependent kinases
14. Cloning and characterization of the Xenopus cyclin-dependent kinase inhibitor p27XIC1
15. A role of cyclin E-Cdk2 in the timing of the midblastula transition in Xenopus embryos
16. P27Xic1, a Cdk inhibitor, promotes the determination of glial cells in Xenopus retina
17. Distinct effects of XBF-1 in regulating the cell cycle inhibitor p27(XIC1) and imparting a neural fate
18. Nuclear accumulation of cyclin E-Cdk2 triggers a concentration-dependent switch for the destruction of p27Xic1
19. Xic1
20. Cyclin E uses Cdc6 as a chromatin-associated receptor required for DNA replication
21. ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex
22. The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators
23. Role for a Xenopus Orc2-related protein in controlling DNA replication
24. The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts
25. XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis
26. ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome
27. The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin
28. A human protein related to yeast Cdc6p
29. Mcm2 and Mcm3, two proteins important for ARS activity, are related in structure and function
30. Geminin, an inhibitor of DNA replication, is degraded during mitosis
31. Repression of origin assembly in metaphase depends on the inhibition of RFL-B/Cdt1 by geminin
32. Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
33. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5
34. A role for Cdk2 kinase in negatively regulating DNA replication during S phase of the cell cycle
35. The Cdt1 protein is required to license DNA for replication in fission yeast
36. The N-end rule pathway in Xenopus egg extracts
37. Identification of NEDD8-conjugation site in human cullin-2
38. Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization
39. Nedd8 modification of cul-1 activates SCF(β(TrCP))-dependent ubiquitination of IκBα
40. A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination
41. Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) towards p27(kip1)
42. Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A
43. Evidence for the sequential action of cdc7 and cdk2 protein kinases during initiation of DNA replication in Xenopus extracts
44. Xenopus Cdc45-dependent loading of DNA polymerase-α onto chromatin under the control of S-phase Cdk
45. Xenopus cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading
46. The Cdc42p effector Gic2p is targeted for ubiquitin-dependent degradation by the SCFGrr1 complex
47. Cyclin-dependent kinase control of centrosome duplication
48. Cyclin synthesis drives the early embryonic cell cycle
49. Cell cycle extracts
50. Protein import into nuclei: Association and dissociation reactions involving transport substrate, transport factors, and nucleoporins
51. Early events in DNA replication require cyclin E and are blocked by p21CIP1