Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets

Diabetes

Volumn 48, Issue 9, 1999, Pages 1747-1753

  Liu, Ye Qi ^a   Tornheim, Keith ^b   Leahy, Jack L ^a,c  

^a UNIVERSITY OF VERMONT   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 PHOSPHOFRUCTOKINASE; CITRATE SYNTHASE; CITRIC ACID; FATTY ACID; GLUCOSE; GLUCOSE 6 PHOSPHATE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; HEXOKINASE; INSULIN; MALATE DEHYDROGENASE; MALIC ACID; OLEIC ACID; PYRUVATE CARBOXYLASE; PYRUVATE DEHYDROGENASE;

ANIMAL CELL; ARTICLE; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID METABOLISM; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLUCOSE UTILIZATION; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; RAT;

ANIMALS; BLOOD GLUCOSE; CELLS, CULTURED; FATTY ACIDS; GLYCEROLPHOSPHATE DEHYDROGENASE; INSULIN; ISLETS OF LANGERHANS; MITOCHONDRIA; OXIDATION-REDUCTION; PHOSPHOFRUCTOKINASE-1; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVIC ACID; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0010991077     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.9.1747     Document Type: Article

References (48)

1. Meglasson MD, Matschinsky FM: Pancreatic islet glucose metabolism and regulation of insulin secretion. Diabetes Metab Rev 2:163-214, 1986
2. Hosokawa H, Corkey BE, Leahy JL: 24 hour islet exposure to fatty acids is associated with a β-cell hypersensitivity to glucose. Diabetologia 40:392-397, 1997
3. Zhou Y-P, Grill VE: Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 93:870-876, 1994
4. Brun T, Assimacopoulos-Jeannet F, Corkey BE, Prentki M: Long chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1. Diabetes 46:393-400, 1997
5. Leahy JL, Bumbalo LM, Chen C: Beta-cell hypersensitivity for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats. Diabetologia 36:1238-1244, 1993
6. Leahy JL: β-Cell dysfunction with chronic hyperglycemia the "overworked β-cell" hypothesis. Diabetes Rev 4:298-319, 1996
7. Milburn JL Jr, Hirose H, Lee YH, Nagasawa Y, Ogawa A, Ohneda M, Beltran-delRio H, Newgard CB, Johnson JH, Unger RH: Pancreatic β-cells in obesity: evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids. J Biol Chem 270:1295-1299, 1995
8. Prentki M, Corkey BE: Are the β-cell signaling molecules malonyl-CoA and cytosolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45:273-283, 1996
9. Unger RH: Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: genetic and clinical implications. Diabetes 44:863-870, 1995
10. Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH: β-Cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-β-cell relationships. Proc Natl Acad Sci USA 91:10878-10882, 1994
11. Zhou Y-P, Grill VE: Palmitate-induced β-cell insensitivity to glucose is coupled to decreased pyruvate dehydrogenase activity and enhanced kinase activity in rat pancreatic islets. Diabetes 44:394-399, 1995
12. Sekine N, Cirulli V, Regazzi R, Brown LJ, Gine E, Tamarit-Rodriguez J, Girotti M, Marie S, MacDonald MJ, Wollheim CB, Rutter GA: Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells: potential role in nutrient sensing. J Biol Chem 269:4895-4902, 1994
13. Eto K, Tsubamoto Y, Terauchi Y, Sugiyama T, Kishimoto T, Takahashi N, Yamauchi N, Kubota N, Murayama S, Aizawa T, Akanuma Y, Aizawa S, Kasai H, Yazaki Y, Kadowaki T: Role of NADH shuffle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science 283: 981-985, 1999
14. MacDonald MJ: Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets: further implication of cytosolic NADPH in insulin secretion. J Biol Chem 270:20051-20058, 1995
15. Liu YQ, Tornheim K, Leahy JL: Fatty acid-induced β-cell hypersensitivity to glucose: increased phosphofructokinase activity and lowered glucose-6-phosphate content. J Clin Invest 101:1870-1875, 1998
16. Liu YQ, Tomheim K, Leahy JL: Shared biochemical properties of glucotoxicity and lipotoxicity in islets decrease citrate synthase activity and increase phosphofructokinase activity. Diabetes 47:1889-1893, 1998
17. Randle PJ, Kerbey AL, Espinal J: Mechanism decreasing glucose oxidation in diabetes and starvation: role of lipid fuels and hormones. Diabetes Metab Rev 4:623-638, 1988
18. Randle PJ, Priestman DA, Mistry S, Halsall A: Mechanisms modifying glucose oxidation in diabetes mellitus. Diabetologia 37 (Suppl. 2):S155-S161, 1994
19. Randle PJ: Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diabetes Metab Rev 14:263-283, 1998
20. Labarca C, Paigen KD: A simple, rapid, and sensitive DNA assay procedure. Analytical Biochem 102:344-352, 1980
21. Albano JDM, Ekins RP, Maritz G, Turner RC: A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moities. Acta Endocrinol 70:487-509, 1972
22. Lowry OH, Passonneau JV: In A Flexible System of Enzymatic Analysis. New York, Academic Press, 1972, p. 179-182
23. Narabayashi H, Lawson JW, Uyeda K: Regulation of phosphofructokinase in perfused rat heart: requirement for fructose 2,6-bisphosphate and a covalent modification. J Biol Chem 260:9750-9758, 1985
24. MacDonald MJ, Efendic S, Östenson C-G: Normalization by insulin treatment of low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of the GK rat. Diabetes 45:886-890, 1996
25. McClure WR, Lardy HA, Kneifel HP: Rat liver pyruvate carboxylase. I. Preparation, properties, and cation specificity. J Biol Chem 246:3569-3578, 1971
26. Englard S, Siegel L: Mitochondrial L-malate dehydrogenase of beef heart. Meth Enzymol 13:99-106, 1969
27. Sener A, Malaisse-Lagae F, Dufrane SP, Malaisse WJ: The coupling of metabolic to secretory events in pancreatic islets: the cytosolic redox state. Biochem J 220:433-440, 1984
28. Malaisse WJ, Malaisse-Lagae F, Sener A: The stimulus-secretion coupling of glucose-induced insulin release: effect of aminooxyacetate upon nutrient-stimulated insulin secretion. Endocrinology 111:392-397, 1982
29. Parvin R, Caramancion MN, Pande SV: Convenient rapid determination of picomole amounts of oxaloacetate and aspartate. Anal Biochem 104:296-299, 1980
30. Lowry OH, Passonneau JV: In A Flexible System of Enzymatic Analysis. New York, Academic Press, 1972, p. 157-158
31. Eizirik DL, Sandler S, Hallberg A, Bendtzen K, Sener A, Malaisse WJ: Differential sensitivity to beta-cell secretagogues in cultured rat pancreatic islets exposed to human interleukin-1 beta. Endocrinology 125:752-759, 1989
32. MacDonald MJ: Evidence for the malate aspartate shuttle in pancreatic islets. Arch Biochem Biophys 213:643-649, 1982
33. MacDonald MJ: High content of mitochondrial glycerol-3-phosphate dehydrogenase in pancreatic islets and its inhibition by diazoxide. J Biol Chem 256:8287-8290, 1981
34. MacDonald MJ: Glucose enters mitochondrial metabolism via both carboxylation and decarboxylation of pyruvate in pancreatic islets. Metabolism 42:1229-1231, 1993
35. Liang Y, Buettger C, Berner DK, Matschinsky FM: Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic beta-cell line (beta HC9). Diabetologia 40:1018-1027, 1997
36. Bollheimer LC, Skelley RH, Chester MW, McGarry JD, Rhodes CJ: Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation. J Clin Invest 101: 1094-1101, 1998
37. MacDonald MT, Tang J, Polonsky KS: Low mitochondnal glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of Zucker diabetic fatty rats. Diabetes 45:1626-1630, 1996
38. MacDonald MJ, McKenzie DI, Walker TM, Kaysen JH: Lack of glyconeogenesis in pancreatic islets: expression of gluconeogenic enzyme genes in islets. Horm Met Res 24:158-160, 1992
39. Khan A, Ling ZC, Landau BR: Quantifying the carboxylation of pyruvate in pancreatic islets. J Biol Chem 271:2539-2542, 1996
40. Schuit F, De Vos A, Farfari S, Moens K, Pipeleers D, Brun T, Prentki M: Metabolic fate of glucose in purified islet cells: glucose-regulated anaplerosis in beta cells. J Biol Chem 272:18572-18579, 1997
41. Brun T, Roche E, Assimacopoulos-Jeannet F, Corkey BE, Kim K-H, Prentki M: Evidence for an anaplerotic/malonyl-CoA pathway in pancreatic β-cell nutrient sensing. Diabetes 45:190-198, 1996
42. Fahien LA, Kmiotek EH, MacDonald MJ, Fibich B, Mandic M: Regulation of malate dehydrogenase activity by glutamate, citrate, alpha-ketoglutarate, and multienzyme interaction. J Biol Chem 263:10687-10697, 1988
43. Kennedy ED, Maechler P, Wollheim CB: Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells. Diabetes 47:374-380, 1998
44. Sener A, Kawazu S, Hutton JC, Boschero AC, Devis G, Somers G, Herchuelz A, Malaisse WJ: The stimulus-secretion coupling of glucose-induced insulin release: effect of exogenous pyruvate on islet function. Biochem J 176: 217-232, 1978
45. + channels in isolated guinea pig cardiac myocytes. Science 238:667-669, 1987
46. Tornheim K: Are metabolic oscillations responsible for normal oscillatory insulin secretion? Diabetes 46:1375-1380, 1997
47. Guimaraes AR, Costa-Rosa LF, Safi DA, Curi R: Effect of a polyunsaturated fatty acid-rich diet on macrophage and lymphocyte metabolism of diabetes rats. Braz J Med Biol Res 26:813-818, 1993
48. Lai JC, Liang BB, Zhai S, Jarvi EJ, Lu DR: Brain mitochondrial citrate synthase and glutamate dehydrogenase: differential inhibition by fatty acyl coenzyme A derivatives. Met Brain Dis 9:143-152, 1994