Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase

Biochemistry

Volumn 38, Issue 8, 1999, Pages 2367-2376

  Narayana, Narendra ^a,d   Diller, Thomas C ^a   Koide, Kazunori ^a,e   Bunnage, Mark E ^a,f   Nicolaou, K C ^a,b   Brunton, Laurence L ^a   Xuong, Nguyen Huu ^a   Ten Eyck, Lynn F ^c   Taylor, Susan S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

^e HARVARD UNIVERSITY   (United States)

^f PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BALANOL; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; PROTEIN SERINE KINASE; PROTEIN TYROSINE KINASE;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITOR COMPLEX; ENZYME INHIBITOR INTERACTION; ENZYME SPECIFICITY; ENZYME STRUCTURE; HYDROGEN BOND; MOLECULAR INTERACTION; MOLECULAR MODEL; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; ANTIBIOTICS, ANTIFUNGAL; AZEPINES; BINDING SITES; CATALYSIS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; HYDROGEN BONDING; HYDROXYBENZOIC ACIDS; LIGANDS; MACROMOLECULAR SUBSTANCES; MICE; MODELS, MOLECULAR;

EID: 0033596738     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9820659     Document Type: Article

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