Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential

Structure

Volumn 5, Issue 12, 1997, Pages 1627-1637

  Prade, Lars ^a   Engh, Richard A ^a   Girod, Andreas ^b   Kinzel, Volker ^b   Huber, Robert ^a   Bossemeyer, Dirk ^b  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Cancer drug design; Crystal structure enzyme flexibility; Protein kinase; Staurosporine

Indexed keywords

ANIMALIA; BOS TAURUS;

EID: 0031574365     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(97)00310-9     Document Type: Article

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