Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 13, 1996, Pages 6308-6313

  Xu, Rui Ming ^a   Carmel, Gilles ^a,c   Kuret, Jeff ^b   Cheng, Xiaodong ^a  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c GENOME THERAPEUTICS CORPORATION   (United States)

Author keywords

casein kinase 1; isoquinoline ring flipping; molecular modelling; N (2 aminoethyl) 5 chloroisoquinoline 8 sulfonamide; x ray crystallography

Indexed keywords

FUNGAL PROTEIN; ISOQUINOLINE DERIVATIVE; PROTEIN KINASE INHIBITOR; SULFONAMIDE;

ARTICLE; COMPETITIVE INHIBITION; CRYSTAL STRUCTURE; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME STRUCTURE; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; SCHIZOSACCHAROMYCES POMBE;

EID: 0029982777     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.13.6308     Document Type: Article

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