Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro

Journal of Neuroscience

Volumn 18, Issue 18, 1998, Pages 7361-7371

  Hanson Jr , Martin G ^a   Shen, Shiliang ^a   Wiemelt, Anthony P ^b   Arthur McMorris, F ^b   Barres, Ben A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WISTAR INSTITUTE   (United States)

Author keywords

Bone morphogenetic proteins; Forskolin; IBMX; Injury; Rat; Regeneration; Trophic factors

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CILIARY NEUROTROPHIC FACTOR; CYCLIC AMP; FIBROBLAST GROWTH FACTOR; SCATTER FACTOR;

ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; EMBRYO; GROWTH STIMULATION; IMMUNOFLUORESCENCE TEST; NERVE INJURY; NERVE REGENERATION; NEUROTROPISM; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD MOTONEURON;

EID: 17344369235     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-18-07361.1998     Document Type: Article

References (16)

1. Arakawa Y, Sendtner M, Thoenen H (1990) Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines. J Neurosci 10:3507-3515.
2. Arce V, Pollock R, Philippe J, Pennica D, Henderson C, deLapeyriere O (1998) Synergistic effects of Schwann- and muscle-derived factors on motoneuron survival involve GDNF and cardiotrophin-1. J Neurosci 18:1440-1448.
3. Barbin G, Manthorpe M, Varon S (1984) Purification of the chick eye ciliary neurotrophic factor. J Neurochem 43:1468-1478.
4. Barde YA (1989) Trophic factors and neuronal survival. Neuron 2:1525-1534.
5. Barde YA (1990) The nerve growth family. Prog Growth Factor Res 2:237-248.
6. Bitgood MJ, McMahon AP (1995) Hedgehog and BMP genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol 172:126-138.
7. Botelho LH, Rothermal JD, Coombs RV, Jastorff B (1988) cAMP analog antagonists of cAMP action. Methods Enzymol 159:159-172.
8. Bottenstein JE, Sato GH (1979) Growth of a rat neuroblastoma cell line in serum-free supplemented medium. Proc Natl Acad Sci USA 76:514-517.
9. Brewer J, Torricelli JR, Evege EK, Price PJ (1993) Optimized survival of hippocampal neurons in B27-supplemented neurobasal, a new serum-free medium combination. J Neurosci Res 35:567-576.
10. Buckmaster EA, Tolkovsky AM (1994) Expression of the cAMP-dependent protein kinase A catalytic subunit from a herpes simplex virus vector extends the survival of rat sympathetic neurons in the absence of NGF. Eur J Neurosci 6:1316-1327.
11. Camu W, Henderson CE (1992) Purification of embryonic rat motoneuron by panning on a monoclonal antibody to the low-affinity NGF receptor. J Neurosci Methods 44:59-70.
12. Camu W, Henderson CE (1994) Rapid purification of embryonic rat motoneurons: an in vitro model for studying MND/ALS pathogenesis. J Neurol Sci 124[Suppl]:73-74.
13. Chijiwa T, Mishima A, Hagiwara M, Sano M, Hayashi K, Inouse T, Naito K, Toshioka T, Hidaka H (1990) Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor or cAMP-dependent protein kinase, H89, of PC12D pheochromocytoma cells. J Biol Chem 265:5267-5272.
14. Deckwerth TL, Elliott JL, Knudson CM, Johnson Jr EM, Snider WD, Korsmeyer SJ (1996) BAX is required for neuronal death after trophic factor deprivation and during development. Neuron 17:401-411.
15. Dubois-Dauphin M, Frankowski H, Tsujimoto Y, Huarte J, Martinou JC (1994) Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death. Proc Natl Acad Sci USA 91:3309-3313.
16. Ebens A, Brose K, Leonardo DE, Hanson MG, Friedhelm B, Birchmeier C, Barres BA, Tessier-Lavigne M (1996) Hepatocyte growth factor/ scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons. Neuron 17:1157-1172.