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Volumn 102, Issue 2, 1998, Pages 329-339

p53-dependent ceramide response to genotoxic stress

Author keywords

Apoptosis; Ceramide; P53; Sphingolipids

Indexed keywords

CERAMIDE; DACTINOMYCIN; PROTEIN P53;

EID: 0032528176     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1180     Document Type: Article
Times cited : (155)

References (77)
  • 1
    • 0026669469 scopus 로고
    • p53 function and dysfunction
    • Vogelstein, B., and K.W. Kinzler. 1992. p53 function and dysfunction. Cell. 70:523-526.
    • (1992) Cell , vol.70 , pp. 523-526
    • Vogelstein, B.1    Kinzler, K.W.2
  • 5
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand, J., G.P. Zambetti, D.C. Olson, D. George, and A.J. Levine. 1992. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell. 69:1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 6
    • 0027179604 scopus 로고
    • Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes
    • Olson, D.C., V. Marechal, J. Momand, J. Chen, C. Romocki, and A.J. Levine. 1993. Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes. Oncogene. 8:2353-2360.
    • (1993) Oncogene , vol.8 , pp. 2353-2360
    • Olson, D.C.1    Marechal, V.2    Momand, J.3    Chen, J.4    Romocki, C.5    Levine, A.J.6
  • 7
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
    • Scheffner, M., B.A. Werness, J.M. Huibregtse, A.J. Levine, and P.M. Howley. 1990. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell. 63:1129-1136.
    • (1990) Cell , vol.63 , pp. 1129-1136
    • Scheffner, M.1    Werness, B.A.2    Huibregtse, J.M.3    Levine, A.J.4    Howley, P.M.5
  • 8
    • 0027358723 scopus 로고
    • The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
    • Scheffner, M., J.M. Huibregtse, R.D. Vierstra, and P.M. Howley. 1993. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell. 75:495-505.
    • (1993) Cell , vol.75 , pp. 495-505
    • Scheffner, M.1    Huibregtse, J.M.2    Vierstra, R.D.3    Howley, P.M.4
  • 9
    • 0027673764 scopus 로고
    • The p53-mdm2 autoregulatory feedback loop: A paradigm for the regulation of growth control by p53?
    • Picksley, S.M., and D.P. Lane. 1993. The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53? Bioessays. 15:689-690.
    • (1993) Bioessays , vol.15 , pp. 689-690
    • Picksley, S.M.1    Lane, D.P.2
  • 10
    • 0029054396 scopus 로고
    • Mdm2 gene amplification and overexpression in non-small cell lung carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations
    • Marchetti, A., F. Buttitta, S. Pellegrini, G. Merlo, A. Chella, C.A. Angeletti, and G. Bevilacqua. 1995. mdm2 gene amplification and overexpression in non-small cell lung carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations. Diagn. Mol. Pathol. 4:93-97.
    • (1995) Diagn. Mol. Pathol. , vol.4 , pp. 93-97
    • Marchetti, A.1    Buttitta, F.2    Pellegrini, S.3    Merlo, G.4    Chella, A.5    Angeletti, C.A.6    Bevilacqua, G.7
  • 11
    • 0029020147 scopus 로고
    • Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status
    • McCann, A.H., A. Kirley, D.N. Carney, N. Corbally, H.M. Magee, G. Keating, and P.A. Dervan. 1995. Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status. Br. J. Cancer. 71:981-985.
    • (1995) Br. J. Cancer , vol.71 , pp. 981-985
    • McCann, A.H.1    Kirley, A.2    Carney, D.N.3    Corbally, N.4    Magee, H.M.5    Keating, G.6    Dervan, P.A.7
  • 12
    • 0027196974 scopus 로고
    • Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
    • Reifenberger, G., L. Liu, K. Ichimura, E.E. Schmidt, and V.P. Collins. 1993. Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res. 53:2736-2739.
    • (1993) Cancer Res. , vol.53 , pp. 2736-2739
    • Reifenberger, G.1    Liu, L.2    Ichimura, K.3    Schmidt, E.E.4    Collins, V.P.5
  • 14
    • 0028568315 scopus 로고
    • Cell cycle control and cancer
    • Hartwell, L.H., and M.B. Kastan. 1994. Cell cycle control and cancer. Science. 266:1821-1828.
    • (1994) Science , vol.266 , pp. 1821-1828
    • Hartwell, L.H.1    Kastan, M.B.2
  • 16
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe, S.W., H.E. Ruley, T. Jacks, and D.E. Housman. 1993. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell. 74:957-967.
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 17
    • 0027251720 scopus 로고
    • Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B
    • Debbas, M., and E. White. 1993. Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev. 7:546-554.
    • (1993) Genes Dev. , vol.7 , pp. 546-554
    • Debbas, M.1    White, E.2
  • 18
    • 0028175990 scopus 로고
    • The p53-dependent gamma-ray response of GADD45
    • Zhan, Q., I. Bae, M.B. Kastan, and A.J. Fornace, Jr. 1994. The p53-dependent gamma-ray response of GADD45. Cancer Res. 54:2755-2760.
    • (1994) Cancer Res. , vol.54 , pp. 2755-2760
    • Zhan, Q.1    Bae, I.2    Kastan, M.B.3    Fornace Jr., A.J.4
  • 21
    • 0027109075 scopus 로고
    • p53, guardian of the genome
    • Lane, D.P. 1992. p53, guardian of the genome. Nature. 358:15-16.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 24
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper, J.W., G.R. Adami, N. Wei, K. Keyomarsi, and S.J. Elledge. 1993. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 75:805-816.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 25
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg, R.A. 1995. The retinoblastoma protein and cell cycle control. Cell. 81:323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 27
    • 0028978183 scopus 로고
    • CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    • CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell. 82:675-684.
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 28
    • 0028070989 scopus 로고
    • p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
    • Caelles, C., A. Helmberg, and M. Karin. 1994. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature. 370: 220-223.
    • (1994) Nature , vol.370 , pp. 220-223
    • Caelles, C.1    Helmberg, A.2    Karin, M.3
  • 29
    • 0028575705 scopus 로고
    • Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kD protein or the cellular Bcl-2 protein
    • Shen, Y., and T. Shenk. 1994. Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kD protein or the cellular Bcl-2 protein. Proc. Natl. Acad. Sci. USA. 91:8940-8944.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8940-8944
    • Shen, Y.1    Shenk, T.2
  • 30
    • 0028847563 scopus 로고
    • Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein
    • Sabatini, P., S. Chiou, L. Rao, and E. White. 1995. Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein. Mol. Cell. Biol. 15:1060-1070.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1060-1070
    • Sabatini, P.1    Chiou, S.2    Rao, L.3    White, E.4
  • 31
    • 0027994349 scopus 로고
    • The sphingomyelin cycle and the second messenger function of ceramide
    • Hannun, Y.A. 1994. The sphingomyelin cycle and the second messenger function of ceramide. J. Biol. Chem. 269:3125-3128.
    • (1994) J. Biol. Chem. , vol.269 , pp. 3125-3128
    • Hannun, Y.A.1
  • 37
    • 0026007737 scopus 로고
    • Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ-interferon: Specific role in cell differentiation
    • Kim, M., C. Linardic, L. Obeid, and Y. Hannun. 1991. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ-interferon: specific role in cell differentiation. J. Biol. Chem. 266:484-489.
    • (1991) J. Biol. Chem. , vol.266 , pp. 484-489
    • Kim, M.1    Linardic, C.2    Obeid, L.3    Hannun, Y.4
  • 41
    • 0029949938 scopus 로고    scopus 로고
    • prICE: A downstream target for ceramide-induced apoptosis and for the inhibitory action of bcl-2
    • Smyth, M.J., D.K. Perry, J. Zhang, G.G. Poirier, Y.A. Hannun, and L.M. Obeid. 1996. prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of bcl-2. Biochem. J. 316:25-28.
    • (1996) Biochem. J. , vol.316 , pp. 25-28
    • Smyth, M.J.1    Perry, D.K.2    Zhang, J.3    Poirier, G.G.4    Hannun, Y.A.5    Obeid, L.M.6
  • 42
    • 0031041448 scopus 로고    scopus 로고
    • Cytokine response modifier a (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)α: Crma and Bcl-2 target distinct components in the apoptotic pathway
    • Dbaibo, G.S., D.K. Perry, C.J. Gamard, R. Platt, G.G. Poirier, L.M. Obeid, and Y.A. Hannun. 1997. Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)α: CrmA and Bcl-2 target distinct components in the apoptotic pathway. J. Exp. Med. 185: 481-490.
    • (1997) J. Exp. Med. , vol.185 , pp. 481-490
    • Dbaibo, G.S.1    Perry, D.K.2    Gamard, C.J.3    Platt, R.4    Poirier, G.G.5    Obeid, L.M.6    Hannun, Y.A.7
  • 43
    • 0027762512 scopus 로고
    • Sphingolipid breakdown products: Anti-proliferative and tumor-suppressor lipids
    • Hannun, Y.A., and C.M. Linardic. 1993. Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids. Biochim. Biophys. Acta Bio-Membr. 1154:223-236.
    • (1993) Biochim. Biophys. Acta Bio-Membr. , vol.1154 , pp. 223-236
    • Hannun, Y.A.1    Linardic, C.M.2
  • 44
    • 0029007640 scopus 로고
    • Ceramide: An endogenous regulator of apoptosis and growth suppression
    • Pushkareva, M., L.M. Obeid, and Y.A. Hannun. 1995. Ceramide: an endogenous regulator of apoptosis and growth suppression. Immunol. Today. 16: 294-297.
    • (1995) Immunol. Today , vol.16 , pp. 294-297
    • Pushkareva, M.1    Obeid, L.M.2    Hannun, Y.A.3
  • 45
    • 0027941170 scopus 로고
    • The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrest
    • Foster, S.A., G.W. Demers, B.G. Etscheid, and D.A. Galloway. 1994. The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrest. J. Virol. 68:5698-5705.
    • (1994) J. Virol. , vol.68 , pp. 5698-5705
    • Foster, S.A.1    Demers, G.W.2    Etscheid, B.G.3    Galloway, D.A.4
  • 46
    • 0027255417 scopus 로고
    • Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis
    • Kaufmann, S.H., S. Desnoyers, Y. Ottaviano, N.E. Davidson, and G.G. Poirier. 1993. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res. 53:3976-3985.
    • (1993) Cancer Res. , vol.53 , pp. 3976-3985
    • Kaufmann, S.H.1    Desnoyers, S.2    Ottaviano, Y.3    Davidson, N.E.4    Poirier, G.G.5
  • 47
    • 0026629794 scopus 로고
    • Ceramide-mediated biology: Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs
    • Bielawska, A., C.M. Linardic, and Y.A. Hannun. 1992. Ceramide-mediated biology: determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs. J. Biol. Chem. 267: 18493-18497.
    • (1992) J. Biol. Chem. , vol.267 , pp. 18493-18497
    • Bielawska, A.1    Linardic, C.M.2    Hannun, Y.A.3
  • 48
    • 0027527545 scopus 로고
    • Selectivity of ceramide-mediated biology: Lack of activity of erythro-dihydroceramide
    • Bielawska, A., H.M. Crane, D. Liotta, L.M. Obeid, and Y.A. Hannun. 1993. Selectivity of ceramide-mediated biology: lack of activity of erythro-dihydroceramide. J. Biol. Chem. 268:26226-26232.
    • (1993) J. Biol. Chem. , vol.268 , pp. 26226-26232
    • Bielawska, A.1    Crane, H.M.2    Liotta, D.3    Obeid, L.M.4    Hannun, Y.A.5
  • 49
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh, E.G., and W.J. Dyer. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Phys. 37:911-917.
    • (1959) Can. J. Biochem. Phys. , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 50
    • 0022970190 scopus 로고
    • Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells
    • Preiss, J., C.R. Loomis, W.R. Bishop, R. Stein, J.E. Niedel, and R.M. Bell. 1986. Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras-and sis-transformed normal rat kidney cells. J. Biol. Chem. 261:8597-8600.
    • (1986) J. Biol. Chem. , vol.261 , pp. 8597-8600
    • Preiss, J.1    Loomis, C.R.2    Bishop, W.R.3    Stein, R.4    Niedel, J.E.5    Bell, R.M.6
  • 51
    • 0014779155 scopus 로고
    • Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots
    • Rouser, G., S. Fleischer, and A. Yamamoto. 1970. Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots. Lipids. 5:494-496.
    • (1970) Lipids , vol.5 , pp. 494-496
    • Rouser, G.1    Fleischer, S.2    Yamamoto, A.3
  • 52
    • 0023971164 scopus 로고
    • Stabilization of type I topoisomerase-DNA covalent complexes by actinomycin D
    • Trask, D.K., and M.T. Muller. 1988. Stabilization of type I topoisomerase-DNA covalent complexes by actinomycin D. Proc. Natl. Acad. Sci. USA. 85:1417-1421.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 1417-1421
    • Trask, D.K.1    Muller, M.T.2
  • 53
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine, A.J. 1997. p53, the cellular gatekeeper for growth and division. Cell. 88:323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 56
    • 0028102478 scopus 로고
    • Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
    • Lazebnik, Y.A., S.H. Kaufmann, S. Desnoyers, G.G. Poirier, and W.C. Earnshaw. 1994. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature. 371:346-347.
    • (1994) Nature , vol.371 , pp. 346-347
    • Lazebnik, Y.A.1    Kaufmann, S.H.2    Desnoyers, S.3    Poirier, G.G.4    Earnshaw, W.C.5
  • 57
    • 0027973061 scopus 로고
    • CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 β-converting enzyme
    • Fernandes-Alnemri, T., G. Litwack, and E.S. Alnemri. 1994. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 β-converting enzyme. J. Biol. Chem. 269:30761-30764.
    • (1994) J. Biol. Chem. , vol.269 , pp. 30761-30764
    • Fernandes-Alnemri, T.1    Litwack, G.2    Alnemri, E.S.3
  • 58
    • 0028990125 scopus 로고
    • Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
    • Tewari, M., L.T. Quan, K. O'Rourke, S. Desnoyers, Z. Zeng, D.R. Beidler, G.G. Poirier, G.S. Salvesen, and V.M. Dixit. 1995. Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell. 81:801-809.
    • (1995) Cell , vol.81 , pp. 801-809
    • Tewari, M.1    Quan, L.T.2    O'Rourke, K.3    Desnoyers, S.4    Zeng, Z.5    Beidler, D.R.6    Poirier, G.G.7    Salvesen, G.S.8    Dixit, V.M.9
  • 60
    • 0028176730 scopus 로고
    • 1-β-D-arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells
    • Strum, J.C., G.W. Small, S.B. Pauig, and L.W. Daniel. 1994. 1-β-D-arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells. J. Biol. Chem. 269:15493-15497.
    • (1994) J. Biol. Chem. , vol.269 , pp. 15493-15497
    • Strum, J.C.1    Small, G.W.2    Pauig, S.B.3    Daniel, L.W.4
  • 62
    • 0029148660 scopus 로고    scopus 로고
    • Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
    • Bose, R., M. Verheij, A. Haimovitz-Friedman, K. Scotto, Z. Fuks, and R.N. Kolesnick. 1996. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell. 82:405-414.
    • (1996) Cell , vol.82 , pp. 405-414
    • Bose, R.1    Verheij, M.2    Haimovitz-Friedman, A.3    Scotto, K.4    Fuks, Z.5    Kolesnick, R.N.6
  • 65
    • 0027319521 scopus 로고
    • p53 is required for radiation-induced apoptosis in mouse thymocytes
    • Lowe, S.W., E.M. Schmitt, S.W. Smith, B.A. Osborne, and T. Jacks. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature. 362:847-849.
    • (1993) Nature , vol.362 , pp. 847-849
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 66
    • 0029054581 scopus 로고
    • Abrogation of p53 function by transfection of HPV16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation
    • Tsang, N.M., H. Nagasawa, C. Li, and J.B. Little. 1995. Abrogation of p53 function by transfection of HPV16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation. Oncogene. 10:2403-2408.
    • (1995) Oncogene , vol.10 , pp. 2403-2408
    • Tsang, N.M.1    Nagasawa, H.2    Li, C.3    Little, J.B.4
  • 68
    • 0028087776 scopus 로고
    • p53, guardian of Rb
    • White, E. 1994. p53, guardian of Rb. Nature. 371:21-22.
    • (1994) Nature , vol.371 , pp. 21-22
    • White, E.1
  • 70
    • 0030448021 scopus 로고    scopus 로고
    • Functions of ceramide in coordinating cellular responses to stress
    • Hannun, Y.A. 1996. Functions of ceramide in coordinating cellular responses to stress. Science. 274:1855-1859.
    • (1996) Science , vol.274 , pp. 1855-1859
    • Hannun, Y.A.1
  • 71
    • 0030983329 scopus 로고    scopus 로고
    • Influence of Bcl-2 overexpression on the ceramide pathway in daunorubicin-induced apoptosis of leukemic cells
    • Allouche, M., A. Bettaieb, C. Vindis, A. Rousse, C. Grignon, and G. Laurent. 1997. Influence of Bcl-2 overexpression on the ceramide pathway in daunorubicin-induced apoptosis of leukemic cells. Oncogene. 14:1837-1845.
    • (1997) Oncogene , vol.14 , pp. 1837-1845
    • Allouche, M.1    Bettaieb, A.2    Vindis, C.3    Rousse, A.4    Grignon, C.5    Laurent, G.6
  • 75
    • 0028072523 scopus 로고
    • DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2
    • Strasser, A., A.W. Harris, T. Jacks, and S. Cory. 1994. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell. 79:329-339.
    • (1994) Cell , vol.79 , pp. 329-339
    • Strasser, A.1    Harris, A.W.2    Jacks, T.3    Cory, S.4


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