Importance of sphingolipids and inhibitors of sphingolipid metabolism as components of animal diets

Journal of Nutrition

Volumn 127, Issue 5 SUPPL., 1997, Pages

  Merrill Jr , Alfred H ^a   Schmelz, Eva Maria ^a   Wang, Elaine ^a   Dillehay, Dirck L ^b   Rice, Larry G ^c   Meredith, Filmore ^c   Riley, Ronald T ^c  

^a Nutrition and Health Sciences Program   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

cancer; ceramide; mycotoxins; sphingolipids

Indexed keywords

CARCINOGEN; FUMONISIN B1; MYCOTOXIN; SPHINGOLIPID; SPHINGOSINE ACYLTRANSFERASE;

ANIMAL FOOD; COLON ADENOCARCINOMA; COLON CARCINOGENESIS; CONFERENCE PAPER; DIET; ENCEPHALOMALACIA; FEEDING; LIPID METABOLISM; LUNG EDEMA; NUTRITION;

EID: 15644367786     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/127.5.830s     Document Type: Conference Paper

References (22)

1. Bezuidenhout, C. S., Gelderblom, W.C.A., Gorstallman, C. P., Horak, R. M., Marasas, W.F.O., Spiteller, G. & Vleggaar, R. (1988) Structure elucidation of the fumonisins, mycotoxins from Fusarium moniliforme. J. Chem. Soc. Commun. 743-745.
2. Blank, M. L., Cress, E. A., Smith, Z. L. & Snyder, F. (1992) Meats and fish consumed in the American diet contain substantial amounts of ether-linked phospholipids. J. Nutr. 122: 1656-1661.
3. Dillehay, D. L. Webb, S. J., Schmelz, E.-M. & Merrill, A. H., Jr. (1994) Dietary sphingomyelin inhibits 1,2-dimethylhydrazine- induced colon cancer in CF1 mice. J. Nutr. 124: 615-620.
4. Hitchcock, C. & Nichols, B. W., eds. (1971) Plant Lipid Biochemistry. Academic Press, London, Great Britain.
5. Imaizumi, K., Tominaga, A., Sato, M. & Sugano, M. (1992) Effects of dietary sphingolipids on levels of serum and liver lipids in rats. Nutr. Res. 12: 543-548.
6. Jensen, R. G. & Newburg, D. S. (1995) Bovine milk lipids. In: Handbook of Milk Composition (Jensen, R. G., ed.), pp. 543-575. Academic Press, New York, NY.
7. Laegrid, A., Otnaess, S.-B. & Fuglesang, J. (1986) Human and bovine milk: comparison of ganglioside composition and enterotoxin-inhibitory activity. Pediatr. Res. 20: 416-421.
8. Mandala, S. M., Thornton, R. A., Frommer, B. R., Curotto, J. E., Rozdilsky, W., Kurtz, M. B., Giacobbe, R. A., Bills, G. F., Cabello, M. A., Martin, I., Pelaez, F. & Harris, G. H. (1995) The discovery of australifungin, a novel inhibitor of sphinganine N-acyltransferase from Sporomiella australis. J. Antibiot. 48: 349-356.
9. 1 alters sphingolipid metabolism and immune function in BALB/c mice: immunological responses to fumonisin B., Mycopathologia 130: 163-170.
10. Merrill, A. H., Jr., Liotta, D. C. & Riley, R. T. (1996) Fumonisins: fungal toxins that shed light on sphingolipid function. Trends Cell Biol. 6: 218-223.
11. Merrill, A. H., Jr. & Sweeley, C. C. (1996) Sphingolipid metabolism and cell signalling. In: New Comprehensive Biochemistry: Biochemistry of Lipids, Lipoproteins, and Membranes (Vance, D. E. & Vance, J. E., eds.), pp. 309-338. Elsevier Science, Amsterdam, The Netherlands.
12. Merrill, A. H., Jr., Wang, E., Gilchrist, D. G. & Riley, R. T. (1993) Fumonisins and other inhibitors of de novo sphingolipid biosynthesis. Adv. Lipid Res. 26: 215-234.
13. Miyake, Y., Kozutsumi, Y., Nakamura, S., Fujita, T. & Kawasaki, T. (1995) Serine palmitoyltransferase is the primary target of a sphingosine-like immuno-suppressant, ISP-1/myriocin. Biochem. Biophys. Res. Commun. 211: 396-403.
14. Ohnishi, M. & Fujino, Y. (1982) Sphingolipids in immature and mature soybeans. Lipids 17: 803-810.
15. Riley, R. T., Voss, K. A., Yoo, H.-S., Gelderblom, W.C.A. & Merrill, A. H., Jr. (1994) Mechanism of fumonisin toxicity and carcinogenicity. J. Food Protect. 57: 638-645.
16. Riley, R. T., Wang, E. & Merrill, A. H., Jr. (1994) Liquid chromatography of sphinganine and sphingosine: use of sphinganine to sphingosine ratio as a biomarker for consumption of fumonisins. J. AOAC Int. 77: 533-540.
17. Riley, R. T., Wang, E., Schroeder, J. J., Smith, E. R., Plattner, R. D., Abbas, H., Yoo, H.-S. & Merrill, A. H., Jr. (1996) Evidence for disruption of sphingolipid metabolism as a contributing factor in the toxicity and carcinogenicity of fumonisins. Natural Toxins 4: 3-15.
18. Schmelz, E. M., Crall, K. J., LaRocque, R., Dillehay, D. L. & Merrill, A. H., Jr. (1994) Uptake and metabolism of sphingolipids in isolated intestinal loops of mice. J. Nutr. 124: 702-712.
19. Wang, E., Norred, W. P., Bacon, C. W., Riley, R. T. & Merrill, A. H., Jr. (1991) Inhibition of sphingolipid biosynthesis by fumonisins: implications for diseases associated with Fusarium moniliforme. J. Biol. Chem. 266: 14486-14490.
20. Wurtman, J. J. (1979) In: Nutrition and the Brain, vol. 5 (Barbeau, A., Growdon, J. H. & Wurtman, J. J., eds.), pp. 83-93. Raven Press, New York, NY.
21. Zeisel, S. H., Char, D. & Sheard, N. F. (1986) Choline, phosphatidylcholine and sphingomyelin in human and bovine milk and infant formulas. J. Nutr. 116: 50-58.
22. Zweerink, M. M., Edison, A. M., Wells, G. B., Pinto, W. & Lester, R. L. (1992) Characterization of a novel, potent, and specific inhibitor of serine palmitoyltransferase. J. Biol. Chem. 267: 25032-25038.