STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor

Science

Volumn 276, Issue 5317, 1997, Pages 1418-1420

  Pfeffer, Lawrence M ^a   Mullersman, Jerald E ^a   Pfeffer, Susan R ^a   Murti, Aruna ^a   Shi, Wei ^a   Yang, Chuan He ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CYTOKINE; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; INTERFERON RECEPTOR; PHENYLALANINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SERINE KINASE; SERINE; STAT3 PROTEIN; TRANSCRIPTION FACTOR; TYROSINE; WORTMANNIN;

ANIMAL CELL; ARTICLE; CERCOPITHECIDAE; CHEMOLUMINESCENCE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE; HUMAN; HUMAN CELL; NONHUMAN; PHOSPHORYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACUTE-PHASE PROTEINS; AMINO ACID SEQUENCE; ANDROSTADIENES; ANIMALS; BINDING SITES; CELL LINE; CLONING, MOLECULAR; CONSERVED SEQUENCE; COS CELLS; DNA-BINDING PROTEINS; ENZYME INHIBITORS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); POINT MUTATION; PROTEIN BINDING; RECEPTOR, INTERFERON ALPHA-BETA; RECEPTORS, INTERFERON; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TYROSINE;

EID: 0030999696     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.276.5317.1418     Document Type: Article

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32. Supported by funds from the Department of Pathology, University of Tennessee Health Science Center. We thank J. E. Darnell Jr. and J. Ihle for antisera to STAT3, E. Croze for antibodies to IFNAR1, M. Kasuga for the p85 cDNA, J. A. Langer for the pcDEF1 expression plasmid, and D. Russell-Harde, S. Biancalana, and D. Nitecki for synthesis of peptides.