The targeting of somatic hypermutation closely resembles that of meiotic mutation

Journal of Immunology

Volumn 166, Issue 2, 2001, Pages 892-899

  Oprea, M ^a   Cowell, L G ^a   Kepler, T B ^a  

^a SANTA FE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CODON; CONTROLLED STUDY; HUMAN; IMMUNOGLOBULIN GENE; MEIOSIS; MUTATION RATE; PRIORITY JOURNAL; PSEUDOGENE; SOMATIC MUTATION;

EID: 0035863918     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.2.892     Document Type: Article

References (46)

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2. Might gene conversion be the mechanism of somatic hypermutation of mammalian Ig genes?
3. Hypothesis: Somatic mutation by gene conversion via the error prone DNA → RNA → DNA information loop
4. The efficiency of antibody maturation; can the rate of B cell division be limiting?
5. Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication
6. Clusters of point mutations are found exclusively around rearranged antibody variable genes
7. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
8. TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line
9. The inactivation of the xpc gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes
10. Immunoglobulin gene hypermutation in germinal centers is independent of the RAG-1, V(D)J recombinase
11. Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2
12. Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process
13. Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice
14. Mismatch repair coopted by hypermutation
15. Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein
16. Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting
17. Somatic hypermutation of immunoglobulin genes is independent of the bloom's syndrome DNA helicase
18. Somatic hypermutation of immunoglobulin genes
19. B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes
20. Somatic hypermutation and the three R's: Repair, replication and recombination
21. h genes suggest different GC and AT mutators
22. Mutational pattern in the nurse shark antigen receptor gene (NAR) is similar to mammalian Ig and to spontaneous mutations in evolution: The translesion synthesis model of somatic hypermutation
23. Somatic hypermutation of human immunoglobulin heavy chain genes: Targeting of RGYW motifs on both DNA strands
24. Both DNA strands of antibody genes are hypermutation targets
25. The nucleotide-replacement spectrum under somatic hypermutation exhibits microsequence dependence that is strand-symmetric and distinct from that under germline mutation
26. An immunoglobulin mutator that targets G.C base pairs
27. Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighboring base sequences on mutagenesis
28. Local sequence dependence of rate of base replacement in mammals
29. Wide variations in neighbor-dependent substitution rates
30. Patterns of somatic mutations in immunoglobulin variable genes
31. Enhanced evolvability in immunoglobulin V genes under somatic hypermutation
32. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction
33. Mutations in Ig V(D)J genes are distributed asymmetrically and independently of the position of V(D)J
34. Somatic hypermutation of the JC intron is markedly reduced in unrearranged κ and H alleles and is unevenly distributed in rearranged alleles
35. Promoter-associated displacement of hypermutations
36. Di- and trinucleotide target preferences in somatic mutagenesis in normal and autoreactive B cells
37. κ genes: Unequal distribution of mutation in 5′ and 3′ flanking regions
38. κ locus
39. A simple method for estimating the intensity of purifying selection in protein-coding genes
40. Nonrandomness of point mutation as reflected in nucleotide substitutions in pseudogenes and its evolutionary implications
41. Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is approximately 1 kb from V(D)J gene
42. DNA methylation and the frequency of CpG in animal DNA
43. The CpG dinucleotide and human genetic disease
44. What limits affinity maturation of antibodies in Xenopus: The rate of somatic mutation or the ability to select mutants?
45. Somatic variation precedes extensive diversification of germline sequences and combinatorial joining in the evolution of immunoglobalin heavy chain diversity