Promoter-associated displacement of hypermutations

International Immunology

Volumn 10, Issue 8, 1998, Pages 1131-1138

  Wu, Peiqing ^a   Claflin, Latham ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Ig V genes; Passenger transgenes; Promoter; Somatic hypermutation

Indexed keywords

IMMUNOGLOBULIN KAPPA CHAIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE MUTATION; IMMUNOGLOBULIN GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SOMATIC MUTATION; STOP CODON; TRANSGENE;

ANIMALS; ANTIBODY DIVERSITY; B-LYMPHOCYTES; CELLS, CULTURED; CODON, TERMINATOR; DNA MUTATIONAL ANALYSIS; ENHANCER ELEMENTS (GENETICS); GENES, IMMUNOGLOBULIN; IMMUNOGLOBULIN JOINING REGION; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; INTRONS; MICE; MICE, TRANSGENIC; MUTAGENESIS; PEYER'S PATCHES; PROMOTER REGIONS (GENETICS); PSEUDOGENES; TRANSCRIPTION, GENETIC; TRANSGENES;

EID: 0031879159     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.8.1131     Document Type: Article

References (52)

1. Berek, C., Berger, A. and Apel, M. 1991. Maturation of the immune response in germinal centers. Cell 67:1121.
2. Jacob, J. and Kelsoe, G. 1992. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers. J. Exp. Med. 176:679.
3. McKean, D., Huppi, K., Bell, M., Staudt, L., Gerhard, W. and Weigert, M. 1984. Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. Proc. Natl Acad. Sci. USA 81:3180.
4. Neuberger, M. S. and Milstein, C. 1995. Somatic hypermutation. Curr. Opin. Immunol. 7:248.
5. Storb, U. 1996. The molecular basis of somatic hypermutation of immunoglobulin genes. Curr. Opin. Immunol. 8:206.
6. Scharff, M. D., Poltoratsky, V. and Green, N. S. 1997. The promotion of V region hypermutation. J. Exp. Med. 185:185.
7. Both, G. W., Taylor, L., Pollard, J. W. and Steele, E. J. 1990 Distribution of mutations around rearranged heavy-chain antibody variable-region genes. Mol. Cell. Biol. 10:5187.
8. Hackett, J. , Jr, Rogerson, B. J., O'Brien, R. L. and Storb, U. 1990. Analysis of somatic mutations in kappa transgenes. J. Exp. Med. 172:131.
9. Lebecque, S. G. and Gearhart, P. J. 1990. Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near promoter, and 3′ boundary is approximately 1 kb from V(D)J gene. J. Exp. Med. 172:1717.
10. Weber, J. S., Berry, J., Manser, T. and Claflin, J. L. 1991. Position of the rearranged V kappa and its 5′ flanking sequences determines the location of somatic mutations in the J kappa locus. J. Immunol. 146:3652.
11. Motoyama, N., Okada, H. and Azuma, T. 1991. Somatic mutation in constant regions of mouse lambda1 light chains. Proc. Natl Acad. Sci. USA 88:7933.
12. κ genes: unequal distribution of mutation in 5′ and 3′ flanking regions. Int. Immunol. 5:255.
13. Rothenfluh, H. S., Taylor, L., Bothwell, A. L. M, Both, G. W. and Steele, E. J. 1993. Somatic hypermutation in 5′ flanking regions of heavy chain antibody variable regions. Eur. J. Immunol. 23:2152.
14. Weber, J. S., Berry, J., Manser, T. and Claflin, J. L. 1994. Mutations in Ig V(D)J genes are distributed asymmetrically and independently of the position of V(D)J. J. Immunol. 153:3594.
15. Rogerson, B. J. 1994. Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes. Mol. Immunol. 31:83.
16. κ gene is in the leader intron. Eur. J. Immunol. 24:1453.
17. Betz, A. G., Milstein, C., Gonzalez-Fernandez, A., Pannell, R., Larson, T. and Neuberger, M. S. 1994. Elements regulating somatic hypermutation of an immunoglobulin κ gene: critical role for the intron enhancer/matrix attachment region. Cell 77:239.
18. Goyenechea, B., Klix, N., Yelamos, J., Williams, G. T., Riddell, A., Neuberger, M. S. and Milstein, C. 1997. Cells strongly expressing Igκ transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers. EMBO J. 16:3987.
19. Yelamos, J., Klix, N., Goyenechea, B., Lozano, F., Chui, Y. L., Gonzalez Fernandez, A., Pannell, R., Neuberger, M. S. and Milstein, C. 1995. Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. Nature 376:225.
20. Winter, D. B., Sattar, N., Mai, J. J. and Gearhart, P. J. 1997. Insertion of 2 kb of bacteriophage DNA between an immunoglobulin promoter and leader exon stops somatic hypermutation in a κ transgene. Mol. Immunol. 34:359.
21. Tumas-Brundage, K. and Manser, T. 1997. The transcriptional promoter regulates hypermutation of the antibody heavy chain locus. J. Exp. Med. 185:239.
22. Peters, A. and Storb, U. 1996. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 4:57.
23. Motoyama, N., Miwa, T., Suzuki, Y., Okada, H. and Azuma, T. 1994. Comparison of somatic mutation frequency among immunoglobulin genes. J. Exp. Med. 179:395.
24. Claflin, J. L., George, J., Dell, C. and Berry, J. 1989. Patterns of mutations and selection in antibodies to the phosphocholine-specific determinant in Proteus morganii. J. Immunol. 143:3054
25. George, J., Penner, S. J., Weber, J., Berry, J. and Claflin, J. L. 1993. Influence of membrane Ig receptor density and affinity on B cell signaling by antigen. Implications for affinity maturation. J. Immunol. 151:5955.
26. O'Brien, R. L., Brinster, R. L. and Storb, U. 1987. Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice. Nature 326:405.
27. Sharpe, M. J., Milstein, C., Jarvis, J. M. and Neuberger, M. S. 1991. Somatic hypermutation of immunoglobulin kappa may depend on sequences 3′ of C kappa and occurs on passenger transgenes. EMBO J. 10:2139.
28. Weber, J. S., Berry, J., Litwin, S. and Claflin, J. L. 1991. Somatic hypermutation of the JC intron is markedly reduced in unrearranged κ and H alleles and is unevenly distributed in rearranged alleles. J. Immunol. 146:3218.
29. Gonzalez-Fernandez, A. and Milstein, C. 1993. Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin κ light-chain transgenes. Proc. Natl Acad. Sci. USA 90:9862.
30. Jacob, J., Kelsoe, G., Rajewsky, K. and Weiss, U. 1991. Intraclonal generation of antibody mutants in germinal centers. Nature 354:389.
31. Smith, D. S., Creadon, G., Jena, P. K., Portanova, J. P., Kotzin, B. and Wysocki, L. J. 1996. Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells. J. Immunol. 156:2642.
32. Betz, A. G., Rada, C., Pannell, R., Milstein, C. and Neuberger, M. S. 1993. Passenger transgenes reveal intransic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proc. Natl Acad. Sci. USA 90:2385.
33. Gonzalez-Fernandez, A., Gupta, S. K., Pannell, R., Neuberger, M. S. and Milstein, C. 1994. Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions. Proc. Natl Acad. Sci. USA 91:12614.
34. Wagner, S. D., Milstein, C. and Neuberger, M. S. 1995. Codon bias targets mutation. Nature 376:732.
35. Lozano, F., Rada, C., Jarvis, J. M. and Milstein, C. 1993. Affinity maturation leads to differential expression of multiple copies of a kappa light-chain transgene. Nature 363:271.
36. Dell, C. L., Lu, Y. and Claflin, J. L. 1989. Molecular analysis of clonal stability and longevity in B cell memory. J. Immunol. 143:3364.
37. Rogozin, I. B. and Kolchanov, N. A. 1992. Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis. Biochim. Biophys. Acta 1171:11.
38. Potter, M. 1977. Antigen-binding myeloma proteins of mice. Adv. Immunol. 25:141.
39. Briles, D. E., Forman, C., Hudak, S. and Claflin, J. L. 1982. Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae. J. Exp. Med. 156:1177.
40. Kenny, J. J., Finkelman, F., Macchiarini, F., Kopp, W. C., Storb, U. and Longo, D. L. 1989 Alteration of the B cell surface phenotype, immune response to phosphocholine and the B cell repertoire in M167 u plus κ transgenic mice. J. Immunol. 142:4466.
41. Friedberg, E. C. 1996. Relationships between DNA repair and transcription. Annu. Rev. Biochem. 65:15.
42. Drapkin, R., Sancar, R. D. and Reinberg, D. 1994. Where transcription meets repair. Cell 77:9.
43. Thomas, B. J. and Rothstein, R. 1989. Elevated recombination rates in transcriptionally active DNA. Cell 56:619.
44. Droge, P. 1993. Transcription-driven site-specific DNA recombination in vitro. Proc. Natl Acad. Sci. USA 90:2759.
45. Wang, Y. and Droge, P. 1996. Differential control of transcription-induced and overall DNA supercoiling by eukaryotic topoisomerases in vitro. EMBO J. 15:581.
46. H gene segments. Cell 40:271.
47. Wong, M.-L. and Hsu, M.-T. 1990. Involvement of topoisomerases in replication, transcription, and packaging of the linear adenovirus genome. J. Virol. 64:691.
48. Wu, H.-Y., Shyy, S., Wang, J. C. and Liu, L. F. 1988. Transcription generates positively and negatively supercoiled domains in the template. Cell 53:433.
49. Brill, S. J. and Sternglanz, R. 1988. Transcription-dependent DNA supercoiling in yeast DNA topoisomerase mutants. Cell 54:403.
50. Wang, J. C. 1996. DNA topoisomerases. Annu. Rev. Biochem. 65:635.
51. Xu, L., Thali, M. and Schaffner, W. 1991. Upstream box/TATA box order is the major determinant of the direction of transcription. Nucleic Acids Res. 19:6699.
52. H441 in B cells. Nucleic Acids Res. 19:5339.