메뉴 건너뛰기




Volumn 13, Issue 6, 1998, Pages 659-664

From a choleretic to an immunomodulator: Historical review of ursodeoxycholic acid as a medicament

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLERETIC AGENT; GAMMA GLUTAMYLTRANSFERASE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; URSODEOXYCHOLIC ACID;

EID: 0031723929     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1746.1998.tb00707.x     Document Type: Review
Times cited : (41)

References (69)
  • 1
    • 0001548231 scopus 로고
    • Untersuchungen uber die Gallen einiger Polarthiere. I. Uber die Galle des Eisbaren. I Abschnitt. Hoppe-Soyler's
    • Hammarsten O. Untersuchungen uber die Gallen einiger Polarthiere. I. Uber die Galle des Eisbaren. I Abschnitt. Hoppe-Soyler's. Z. Physiol. Chem. 1901; 32: 435-66.
    • (1901) Z. Physiol. Chem. , vol.32 , pp. 435-466
    • Hammarsten, O.1
  • 2
    • 7344249865 scopus 로고
    • Untersuchungen uber die Gallen einiger Polarthiere. I. Uber die Galle des Eisbaren. II Abschnitt. Hoppe-Seyler's
    • Hammarsten O. Untersuchungen uber die Gallen einiger Polarthiere. I. Uber die Galle des Eisbaren. II Abschnitt. Hoppe-Seyler's. Z. Physiol. Chem. 1902; 36: 525-55.
    • (1902) Z. Physiol. Chem. , vol.36 , pp. 525-555
    • Hammarsten, O.1
  • 3
    • 84963097394 scopus 로고
    • Uber die Ursodeoxycholsaure aus Barengallen und ihre physiologische Wirkung
    • Shoda M. Uber die Ursodeoxycholsaure aus Barengallen und ihre physiologische Wirkung. J. Biochem. 1927; 7: 505-17.
    • (1927) J. Biochem. , vol.7 , pp. 505-517
    • Shoda, M.1
  • 4
    • 84941488850 scopus 로고
    • Uber the Konstitution der ursodesoxycholsaure
    • Iwasaki T. Uber the Konstitution der ursodesoxycholsaure. Z. Physiol. Chem. 1936; 244: 181-93.
    • (1936) Z. Physiol. Chem. , vol.244 , pp. 181-193
    • Iwasaki, T.1
  • 5
    • 0006295754 scopus 로고
    • Studies on the synthesis of ursodeoxycholic acid
    • Kanazawa T, Shimazaki A, Sato T et al. Studies on the synthesis of ursodeoxycholic acid. Jpn. J. Chem. 1955; 76: 297-301.
    • (1955) Jpn. J. Chem. , vol.76 , pp. 297-301
    • Kanazawa, T.1    Shimazaki, A.2    Sato, T.3
  • 8
    • 0017754827 scopus 로고
    • Dissolution of cholesterol gallstones by ursodeoxycholic acid
    • Nakagawa S, Makino I, Ishizaki K, Dohi I. Dissolution of cholesterol gallstones by ursodeoxycholic acid. Lancet 1977; 2: 367-9.
    • (1977) Lancet , vol.2 , pp. 367-369
    • Nakagawa, S.1    Makino, I.2    Ishizaki, K.3    Dohi, I.4
  • 9
    • 0016151824 scopus 로고
    • Retrospective studies on gallstone disappearance
    • Sugata F, Shimizu M. Retrospective studies on gallstone disappearance. Jpn. J. Gastroenterol. 1974; 71: 75-80.
    • (1974) Jpn. J. Gastroenterol. , vol.71 , pp. 75-80
    • Sugata, F.1    Shimizu, M.2
  • 10
    • 0020318866 scopus 로고
    • Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis
    • Bachrach W, Hofmann AF. Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. Dig. Dis. Sci. 1982; 27: 737-61.
    • (1982) Dig. Dis. Sci. , vol.27 , pp. 737-761
    • Bachrach, W.1    Hofmann, A.F.2
  • 11
    • 0019976525 scopus 로고
    • Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis
    • Bachrach W, Hofmann AF. Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. Dig. Dis. Sci. 1982; 27: 833-56.
    • (1982) Dig. Dis. Sci. , vol.27 , pp. 833-856
    • Bachrach, W.1    Hofmann, A.F.2
  • 12
    • 0019507465 scopus 로고
    • Chenodiol (chenodeoxycholic acid) for dissolution of gallstones; the national cooperative gallstone study. A controlled trial of efficacy and safety
    • Schoenfield LJ, Lachin JM, The Steering committee, The National Cooperative Gallstone Study Group. Chenodiol (chenodeoxycholic acid) for dissolution of gallstones; the national cooperative gallstone study. A controlled trial of efficacy and safety. Ann. Intern. Med. 1981; 95: 257-82.
    • (1981) Ann. Intern. Med. , vol.95 , pp. 257-282
    • Schoenfield, L.J.1    Lachin, J.M.2
  • 13
    • 0019864171 scopus 로고
    • Cholesterol gallstone dissolution in bile; dissolution kinetics of crystalline (anhydrate and mono hydrate) cholesterol with chenodeoxycholate, ursodeoxycholate, and their glycine and taurine conjugates
    • Igimi H, Carey MC. Cholesterol gallstone dissolution in bile; dissolution kinetics of crystalline (anhydrate and mono hydrate) cholesterol with chenodeoxycholate, ursodeoxycholate, and their glycine and taurine conjugates. J. Lipid Res. 1981; 22: 254-70.
    • (1981) J. Lipid Res. , vol.22 , pp. 254-270
    • Igimi, H.1    Carey, M.C.2
  • 14
    • 0020519522 scopus 로고
    • Liquid crystal formation in ursodeoxycholate-rich human gallbladder bile
    • Igimi H, Asakawa S, Watanabe D, Shimura H. Liquid crystal formation in ursodeoxycholate-rich human gallbladder bile. Gastroenterology Jpn. 1983; 18: 93-7.
    • (1983) Gastroenterology Jpn , vol.18 , pp. 93-97
    • Igimi, H.1    Asakawa, S.2    Watanabe, D.3    Shimura, H.4
  • 15
    • 0020504784 scopus 로고
    • The developmental process from micelle to liquid chrystal in the ursodeoxycholate, phosphatidylcholine and cholesterol solution
    • Igimi H, Nishijima S, Shimura H. The developmental process from micelle to liquid chrystal in the ursodeoxycholate, phosphatidylcholine and cholesterol solution. J. Phar. Dyn. 1983; 6: 267-71.
    • (1983) J. Phar. Dyn. , vol.6 , pp. 267-271
    • Igimi, H.1    Nishijima, S.2    Shimura, H.3
  • 16
    • 0014283788 scopus 로고
    • The physicochemical basis of cholesterol gallstone formation in man
    • Admirand WH, Small DM. The physicochemical basis of cholesterol gallstone formation in man. J. Clin. Invest. 1968; 47: 1043-52.
    • (1968) J. Clin. Invest. , vol.47 , pp. 1043-1052
    • Admirand, W.H.1    Small, D.M.2
  • 17
    • 0017805654 scopus 로고
    • The physical chemistry of cholesterol by solubility in bile; relationship to gallstone formation and dissolution in man
    • Carey M, Small DM. The physical chemistry of cholesterol by solubility in bile; relationship to gallstone formation and dissolution in man. J. Clin. Invest. 1978; 61: 998-1026.
    • (1978) J. Clin. Invest. , vol.61 , pp. 998-1026
    • Carey, M.1    Small, D.M.2
  • 18
    • 84895596563 scopus 로고
    • The experience of ursodeoxycholic acid administration for patients with chronic hepatitis
    • in Japanese
    • Ichida F. The experience of ursodeoxycholic acid administration for patients with chronic hepatitis. Sindan-to-tiryou. 1961; 49: 388-92 (in Japanese).
    • (1961) Sindan-to-tiryou , vol.49 , pp. 388-392
    • Ichida, F.1
  • 19
    • 85038528642 scopus 로고
    • Effect of urso-san on chronic liver diseases
    • in Japanese
    • Wakahara T, Yoshida H, Bandou T et al. Effect of urso-san on chronic liver diseases. Sindan-to-tiryou. 1975; 63: 1070-3 (in Japanese).
    • (1975) Sindan-to-tiryou , vol.63 , pp. 1070-1073
    • Wakahara, T.1    Yoshida, H.2    Bandou, T.3
  • 20
    • 0001347709 scopus 로고
    • Effect of ursodeoxycholic acid on chronic hepatitis; A double blind trial
    • in Japanese
    • Yamanaka M, Ohtou M, Obata H et al. Effect of ursodeoxycholic acid on chronic hepatitis; a double blind trial. Sindan-to-tiryou. 1976; 64: 2150-7 (in Japanese).
    • (1976) Sindan-to-tiryou , vol.64 , pp. 2150-2157
    • Yamanaka, M.1    Ohtou, M.2    Obata, H.3
  • 21
    • 0021809682 scopus 로고
    • Gallstone dissolution with ursodeoxycholic acid in patients with chronic active hepatitis and two years follow up; A pilot study
    • Leuschner U, Leuschner M, Sieratzki J, Kurtz W, Hubner K. Gallstone dissolution with ursodeoxycholic acid in patients with chronic active hepatitis and two years follow up; a pilot study. Dig. Dis. Sci. 1985; 30: 642-9.
    • (1985) Dig. Dis. Sci. , vol.30 , pp. 642-649
    • Leuschner, U.1    Leuschner, M.2    Sieratzki, J.3    Kurtz, W.4    Hubner, K.5
  • 22
    • 0024834972 scopus 로고
    • Effect of different doses of ursodeoxycholic acid in chronic liver disease
    • Podda M, Ghezzi C, Battezzati PM et al. Effect of different doses of ursodeoxycholic acid in chronic liver disease. Dig. Dis. Sci. 1989; 34 (Suppl): S59-5.
    • (1989) Dig. Dis. Sci. , vol.34 , Issue.SUPPL.
    • Podda, M.1    Ghezzi, C.2    Battezzati, P.M.3
  • 23
    • 0024534144 scopus 로고
    • Effect of ursodeoxycholic acid treatment on alanine aminotransferase and gamma-glutamyltranspeptidase serum levels in patients with hyper-transaminasemia
    • Ballentani S, Tabarroni G, Barchi T et al. Effect of ursodeoxycholic acid treatment on alanine aminotransferase and gamma-glutamyltranspeptidase serum levels in patients with hyper-transaminasemia. J. Hepatol. 1989; 8: 7-12.
    • (1989) J. Hepatol. , vol.8 , pp. 7-12
    • Ballentani, S.1    Tabarroni, G.2    Barchi, T.3
  • 24
    • 0025251873 scopus 로고
    • Treatment of chronic liver disease with ursodeoxycholic acid
    • Guslandi M. Treatment of chronic liver disease with ursodeoxycholic acid. J. Int. Med. Res. 1990; 18: 497-505.
    • (1990) J. Int. Med. Res. , vol.18 , pp. 497-505
    • Guslandi, M.1
  • 25
    • 0025257161 scopus 로고
    • Effects of ursodeoxycholic acid and taurine on serum liver enzymes and bile acids in chronic hepatitis
    • Podda M, Ghezzi C, Battezzati PM, Crosignani A, Zuin M, Podda A. Effects of ursodeoxycholic acid and taurine on serum liver enzymes and bile acids in chronic hepatitis. Gastroenterology 1990; 98: 1044-50.
    • (1990) Gastroenterology , vol.98 , pp. 1044-1050
    • Podda, M.1    Ghezzi, C.2    Battezzati, P.M.3    Crosignani, A.4    Zuin, M.5    Podda, A.6
  • 26
    • 0025782642 scopus 로고
    • Effects of ursodeoxycholic acid (UDCA) on serum liver damage indices in patients with chronic active hepatitis. A double-blind controlled study
    • Rolandi E, Franceschini R, Caraldi A, Cicchetti V, Carati L, Barreca T. Effects of ursodeoxycholic acid (UDCA) on serum liver damage indices in patients with chronic active hepatitis. A double-blind controlled study. Eur. J. Clin. Pharmacol. 1991; 40: 473-6.
    • (1991) Eur. J. Clin. Pharmacol. , vol.40 , pp. 473-476
    • Rolandi, E.1    Franceschini, R.2    Caraldi, A.3    Cicchetti, V.4    Carati, L.5    Barreca, T.6
  • 28
    • 0026062522 scopus 로고
    • Effect of ursodeoxycholic acid on serum liver enzyme and bile acid metabolism in chronic active hepatitis; a dose-response study
    • Crosignani A, Battezzati PM, Setchell DR et al. Effect of ursodeoxycholic acid on serum liver enzyme and bile acid metabolism in chronic active hepatitis; a dose-response study. Hepatology 1991; 13: 339-44.
    • (1991) Hepatology , vol.13 , pp. 339-344
    • Crosignani, A.1    Battezzati, P.M.2    Setchell, D.R.3
  • 29
    • 0019294767 scopus 로고
    • Hypercholeresis induced by ursodeoxycholic acid in the rat; possible role of bicarbonate transport
    • Dumont M, Eringer S, Uchman S. Hypercholeresis induced by ursodeoxycholic acid in the rat; possible role of bicarbonate transport. Gastroenterology 1980; 79: 82-9.
    • (1980) Gastroenterology , vol.79 , pp. 82-89
    • Dumont, M.1    Eringer, S.2    Uchman, S.3
  • 30
    • 0019467213 scopus 로고
    • Biliary transport maximum of tauroursodeoxycholate is twice as high as that of taurocholate in the rat
    • Kitani K, Kanai S. Biliary transport maximum of tauroursodeoxycholate is twice as high as that of taurocholate in the rat. Life Sci 1981; 29: 269-75.
    • (1981) Life Sci , vol.29 , pp. 269-275
    • Kitani, K.1    Kanai, S.2
  • 31
    • 0020031555 scopus 로고
    • Tauroursodeoxycholate prevents taurocholate increased cholestasis
    • Kitani K, Kanai S. Tauroursodeoxycholate prevents taurocholate increased cholestasis. Life Sci. 1982; 90: 515-23.
    • (1982) Life Sci , vol.90 , pp. 515-523
    • Kitani, K.1    Kanai, S.2
  • 32
    • 0342662084 scopus 로고
    • Tauroursodeoxycholate prevents biliary protein excretion induced by other bile salts in the rat
    • Kitani K, Ohta M, Kanai S. Tauroursodeoxycholate prevents biliary protein excretion induced by other bile salts in the rat. Am. J. Physiol. 1985; 248: G407-17.
    • (1985) Am. J. Physiol. , vol.248
    • Kitani, K.1    Ohta, M.2    Kanai, S.3
  • 33
    • 0021525242 scopus 로고
    • Therapeutic effect of ursodeoxycholic acid on sulpyrine-induced intrahepatic cholestasis; a case report
    • in Japanese
    • Tomoda T, Moriwaki H, Onishi H et al. Therapeutic effect of ursodeoxycholic acid on sulpyrine-induced intrahepatic cholestasis; a case report. Jpn. J. Gastroenterol. 1984; 81: 2821-5 (in Japanese).
    • (1984) Jpn. J. Gastroenterol. , vol.81 , pp. 2821-2825
    • Tomoda, T.1    Moriwaki, H.2    Onishi, H.3
  • 34
    • 0023125182 scopus 로고
    • Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis?
    • Poupon RE, Cheretien Y, Popon R, Ballet F, Calmus Y, Darnis F. Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis? Lancet 1987; 1: 834-6.
    • (1987) Lancet , vol.1 , pp. 834-836
    • Poupon, R.E.1    Cheretien, Y.2    Popon, R.3    Ballet, F.4    Calmus, Y.5    Darnis, F.6
  • 35
    • 0024811098 scopus 로고
    • Effect of ursodeoxycholic acid administration on biliary lipid secretion in primary biliary cirrhosis
    • Roda E, Mazzella G, Bazzoli F et al. Effect of ursodeoxycholic acid administration on biliary lipid secretion in primary biliary cirrhosis. Dig. Dis. Sci. 1989; 34: S52-8.
    • (1989) Dig. Dis. Sci. , vol.34
    • Roda, E.1    Mazzella, G.2    Bazzoli, F.3
  • 36
    • 0025176475 scopus 로고
    • Improvement of biliary enzyme levels and itching as a result of long-term administration of ursodeoxycholic acid in primary biliary cirrhosis
    • Matuzaki Y, Tanaka N, Osuga T et al. Improvement of biliary enzyme levels and itching as a result of long-term administration of ursodeoxycholic acid in primary biliary cirrhosis. Am. J. Gastroenterol. 1990; 85: 15-23.
    • (1990) Am. J. Gastroenterol. , vol.85 , pp. 15-23
    • Matuzaki, Y.1    Tanaka, N.2    Osuga, T.3
  • 38
    • 0028096196 scopus 로고
    • Different response to ursodeoxycholic acid (UDCA) in primary biliary cirrhosis according to severity of diseases
    • Floreani A, Zappala F, Mazzetto M, Naccarato R, Plebani M, Chiramonte M. Different response to ursodeoxycholic acid (UDCA) in primary biliary cirrhosis according to severity of diseases. Dis. Dis. Sci. 1994; 39: 9-14.
    • (1994) Dis. Dis. Sci. , vol.39 , pp. 9-14
    • Floreani, A.1    Zappala, F.2    Mazzetto, M.3    Naccarato, R.4    Plebani, M.5    Chiramonte, M.6
  • 39
    • 0025876404 scopus 로고
    • A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis
    • Poupon RE, Balkau B, Eschwege E, Poupon R, The UDCA-PBC Study Group. A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. N. Engl. J. Med. 1991; 324: 1548-54.
    • (1991) N. Engl. J. Med. , vol.324 , pp. 1548-1554
    • Poupon, R.E.1    Balkau, B.2    Eschwege, E.3    Poupon, R.4
  • 40
    • 0025611350 scopus 로고
    • A multi-center double blind controlled trial of ursodeoxycholic acid for primary biliary cirrhosis
    • Oda H, Toda G, Ikeda Y et al. A multi-center double blind controlled trial of ursodeoxycholic acid for primary biliary cirrhosis. Gastroenterol. Jpn. 1990; 25: 774-80.
    • (1990) Gastroenterol. Jpn. , vol.25 , pp. 774-780
    • Oda, H.1    Toda, G.2    Ikeda, Y.3
  • 41
    • 0028294206 scopus 로고
    • Ursodiol for the long-term treatment of primary biliary cirrhosis
    • Poupon RE, Poupon R, Balkau B, The UDCA-PBC Study Group. Ursodiol for the long-term treatment of primary biliary cirrhosis. N. Engl. J. Med. 1994; 330: 1342-7.
    • (1994) N. Engl. J. Med. , vol.330 , pp. 1342-1347
    • Poupon, R.E.1    Poupon, R.2    Balkau, B.3
  • 42
    • 0028331716 scopus 로고
    • Ursodeoxycholic acid in the treatment of primary biliary cirrhosis
    • Lindor KD, Dickson ER, Baldus WP et al. Ursodeoxycholic acid in the treatment of primary biliary cirrhosis. Gastroenterology 1994; 106: 1284-90.
    • (1994) Gastroenterology , vol.106 , pp. 1284-1290
    • Lindor, K.D.1    Dickson, E.R.2    Baldus, W.P.3
  • 43
    • 0028346255 scopus 로고
    • The Canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis
    • Heathcote EJ, Cauch-Dudek K, Walker V et al. The Canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 1994; 19: 1149-56.
    • (1994) Hepatology , vol.19 , pp. 1149-1156
    • Heathcote, E.J.1    Cauch-Dudek, K.2    Walker, V.3
  • 44
    • 0029122841 scopus 로고
    • The combination of ursodeoxycholic acid and methotrexate for patients with primary biliary cirrhosis; the results of a pilot study
    • Lindor KD, Dickson ER, Jorgensen RA et al. The combination of ursodeoxycholic acid and methotrexate for patients with primary biliary cirrhosis; the results of a pilot study. Hepatology 1995; 22: 1158-62.
    • (1995) Hepatology , vol.22 , pp. 1158-1162
    • Lindor, K.D.1    Dickson, E.R.2    Jorgensen, R.A.3
  • 45
    • 0030046999 scopus 로고    scopus 로고
    • Effects of additional administration of colchicine in ursodeoxycholic acid-treated patients with primary biliary cirrhosis: A prospective randomized study
    • Ikeda T, Tozuka S, Noguchi O et al. Effects of additional administration of colchicine in ursodeoxycholic acid-treated patients with primary biliary cirrhosis: a prospective randomized study. J. Hepatol. 1996; 24: 88-94.
    • (1996) J. Hepatol. , vol.24 , pp. 88-94
    • Ikeda, T.1    Tozuka, S.2    Noguchi, O.3
  • 46
    • 0027963209 scopus 로고
    • A multicenter randomized controlled dose study of ursodeoxycholic acid for chronic hepatitis C
    • Tanaka S, Ito Y, Yokosaka O et al. A multicenter randomized controlled dose study of ursodeoxycholic acid for chronic hepatitis C. Hepatology 1994; 20: 558-64.
    • (1994) Hepatology , vol.20 , pp. 558-564
    • Tanaka, S.1    Ito, Y.2    Yokosaka, O.3
  • 47
    • 0030028668 scopus 로고    scopus 로고
    • Efficacy of ursodeoxycholic acid therapy in chronic viral hepatitis C with high serum gamma-glutamyltranspeptidase levels
    • Kiso S, Kawata S, Imai Y, Tamura S, Inui Y, Ito N. Efficacy of ursodeoxycholic acid therapy in chronic viral hepatitis C with high serum gamma-glutamyltranspeptidase levels. J. Gastroenterol. 1996; 31: 75-80.
    • (1996) J. Gastroenterol. , vol.31 , pp. 75-80
    • Kiso, S.1    Kawata, S.2    Imai, Y.3    Tamura, S.4    Inui, Y.5    Ito, N.6
  • 48
    • 0028960364 scopus 로고
    • Interferon and ursodeoxycholic acid combination therapy in the treatment of chronic viral C hepatitis: Results from a controlled randomized trial in 80 patients
    • Boucher E, Jouanolle H, Andre P et al. Interferon and ursodeoxycholic acid combination therapy in the treatment of chronic viral C hepatitis: Results from a controlled randomized trial in 80 patients. Hepatology 1995; 21: 322-7.
    • (1995) Hepatology , vol.21 , pp. 322-327
    • Boucher, E.1    Jouanolle, H.2    Andre, P.3
  • 49
    • 0028814835 scopus 로고
    • Recombinant interferon-alpha and ursodeoxycholic acid versus interferon-alpha alone treatment of chronic hepatitis C: A randomized clinical trial with long-term follow-up
    • Angelico M, Gandin C, Pescarmona E et al. Recombinant interferon-alpha and ursodeoxycholic acid versus interferon-alpha alone treatment of chronic hepatitis C: A randomized clinical trial with long-term follow-up. Am. J. Gastroenterol. 1995; 90: 263-9.
    • (1995) Am. J. Gastroenterol. , vol.90 , pp. 263-269
    • Angelico, M.1    Gandin, C.2    Pescarmona, E.3
  • 50
    • 0030482377 scopus 로고    scopus 로고
    • Efficacy of ursodeoxycholic acid in combination with interferon-α in treating chronic hepatitis C: Results of long-term followup trial
    • Tanaka K, Kondo M, Sakasguchi T et al. Efficacy of ursodeoxycholic acid in combination with interferon-α in treating chronic hepatitis C: Results of long-term followup trial. J. Gastroenterol. Hepatol. 1996; 11: 1155-60.
    • (1996) J. Gastroenterol. Hepatol. , vol.11 , pp. 1155-1160
    • Tanaka, K.1    Kondo, M.2    Sakasguchi, T.3
  • 51
    • 0026730984 scopus 로고
    • Ursodeoxycholic acid for treatment of primary sclerosing cholangitis; placebo-controlled trial
    • Beuers U, Spengler U, Kruis W et al. Ursodeoxycholic acid for treatment of primary sclerosing cholangitis; placebo-controlled trial. Hepatology 1992; 16: 707-14.
    • (1992) Hepatology , vol.16 , pp. 707-714
    • Beuers, U.1    Spengler, U.2    Kruis, W.3
  • 52
    • 0027954535 scopus 로고
    • Effect of ursodeoxycholic acid on liver and bile duct disease in primary sclerosing cholangitis, A 3-year pilot study with a placebo-controlled study period
    • Stiehl A, Walker S, Stieh L, Rudolph G, Hofmann WJ, Theilmann L. Effect of ursodeoxycholic acid on liver and bile duct disease in primary sclerosing cholangitis, A 3-year pilot study with a placebo-controlled study period. J. Hepatol. 1994; 20: 57-64.
    • (1994) J. Hepatol. , vol.20 , pp. 57-64
    • Stiehl, A.1    Walker, S.2    Stieh, L.3    Rudolph, G.4    Hofmann, W.J.5    Theilmann, L.6
  • 53
    • 85038528685 scopus 로고
    • Effect of ursodeoxycholic acid on autoimmune hepatitis
    • Mima S, Sekiya T, Kanagawa H et al. Effect of ursodeoxycholic acid on autoimmune hepatitis. Acta Hepatologica Japonica 1992; 34: 849-50.
    • (1992) Acta Hepatologica Japonica , vol.34 , pp. 849-850
    • Mima, S.1    Sekiya, T.2    Kanagawa, H.3
  • 54
    • 0028894588 scopus 로고
    • Effect of long term ursodeoxycholic acid treatment on serum liver enzyme and serum bile acid metabolism in chronic hepatitis
    • Nakamura K, Akiyama K, Makino I. Effect of long term ursodeoxycholic acid treatment on serum liver enzyme and serum bile acid metabolism in chronic hepatitis. Jpn. J. Gastroenterol. 1995; 92: 62-71.
    • (1995) Jpn. J. Gastroenterol. , vol.92 , pp. 62-71
    • Nakamura, K.1    Akiyama, K.2    Makino, I.3
  • 55
    • 0030834150 scopus 로고    scopus 로고
    • Present status of autoimmune hepatitis in Japan - Correlating the characteristics with international criteria in an area with a high rate of HCV infection
    • Toda G, Zeniya M, Watanabe F et al. Present status of autoimmune hepatitis in Japan - correlating the characteristics with international criteria in an area with a high rate of HCV infection. J. Hepatol. 1997; 26: 1207-12.
    • (1997) J. Hepatol. , vol.26 , pp. 1207-1212
    • Toda, G.1    Zeniya, M.2    Watanabe, F.3
  • 57
    • 0018899362 scopus 로고
    • Bile acid induced lymphoproliferative response to phytohaemagglutinin and pokeweed mitogen; an in vitro study
    • Gianni L, Di Padova F, Zuin M, Podda M. Bile acid induced lymphoproliferative response to phytohaemagglutinin and pokeweed mitogen; an in vitro study. Gastroenterology 1980; 78: 231-5.
    • (1980) Gastroenterology , vol.78 , pp. 231-235
    • Gianni, L.1    Di Padova, F.2    Zuin, M.3    Podda, M.4
  • 59
    • 0027221534 scopus 로고
    • The immunosuppressive effect of ursodeoxycholic acid: A comparative in vitro study on human peripheral blood mononuclear cells
    • Lacaille F, Paradis K. The immunosuppressive effect of ursodeoxycholic acid: a comparative in vitro study on human peripheral blood mononuclear cells. Hepatology 1993; 18: 165-72.
    • (1993) Hepatology , vol.18 , pp. 165-172
    • Lacaille, F.1    Paradis, K.2
  • 60
    • 0026642157 scopus 로고
    • Immunomodulatory effects of ursodeoxycholic acid on immune responses
    • Yoshikawa M, Tsujii T, Matsumura K et al. Immunomodulatory effects of ursodeoxycholic acid on immune responses. Hepatology 1992; 16: 358-64.
    • (1992) Hepatology , vol.16 , pp. 358-364
    • Yoshikawa, M.1    Tsujii, T.2    Matsumura, K.3
  • 61
    • 0026054966 scopus 로고
    • Hepatocellular and biliary expression of HLA antigens in primary biliary cirrhosis before and after ursodeoxycholic acid therapy
    • Terasaki S, Nakamura Y, Ogino H, Unoura M, Kabayashi K. Hepatocellular and biliary expression of HLA antigens in primary biliary cirrhosis before and after ursodeoxycholic acid therapy. Am. J. Gastroenterol. 1991; 86: 1194-9.
    • (1991) Am. J. Gastroenterol. , vol.86 , pp. 1194-1199
    • Terasaki, S.1    Nakamura, Y.2    Ogino, H.3    Unoura, M.4    Kabayashi, K.5
  • 62
    • 0025098908 scopus 로고
    • Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: Effect of ursodeoxycholic acid
    • Calmus Y, Gane P, Rouger P, Poupon R. Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid. Hepatology 1990; 11: 12-15.
    • (1990) Hepatology , vol.11 , pp. 12-15
    • Calmus, Y.1    Gane, P.2    Rouger, P.3    Poupon, R.4
  • 63
    • 0027492939 scopus 로고
    • Regulation of the major histocompatibility complex class I mRNA expression by bile acids in cultured human hepatoma cells
    • Hirano F, Tanaka H, Makino I. Regulation of the major histocompatibility complex class I mRNA expression by bile acids in cultured human hepatoma cells. Biochem. Biophys Res. Commun. 1993; 195: 1408-14.
    • (1993) Biochem. Biophys Res. Commun. , vol.195 , pp. 1408-1414
    • Hirano, F.1    Tanaka, H.2    Makino, I.3
  • 64
    • 0030030787 scopus 로고    scopus 로고
    • Effects of ursodeoxycholic acid and chenodeoxycholic acid on major histocompatibility complex class I gene expression
    • Hirano F, Tanaka H, Makino Y et al. Effects of ursodeoxycholic acid and chenodeoxycholic acid on major histocompatibility complex class I gene expression. J. Gastroenterol. 1996; 31: 55-60.
    • (1996) J. Gastroenterol. , vol.31 , pp. 55-60
    • Hirano, F.1    Tanaka, H.2    Makino, Y.3
  • 65
    • 0030043423 scopus 로고    scopus 로고
    • Ligand-independent activation of the glucocorticoid receptor by ursodeoxycholic acid
    • Tanaka H, Makino Y, Miura T et al. Ligand-independent activation of the glucocorticoid receptor by ursodeoxycholic acid. J. Immunol. 1996; 156: 1601-8.
    • (1996) J. Immunol. , vol.156 , pp. 1601-1608
    • Tanaka, H.1    Makino, Y.2    Miura, T.3
  • 66
    • 0026485634 scopus 로고
    • Ursodeoxycholic acid-dependent activation of the glucocorticoid receptor
    • Tanaka H, Makino I. Ursodeoxycholic acid-dependent activation of the glucocorticoid receptor. Biochem. Biophys. Res. Commun. 1992; 188: 942-8.
    • (1992) Biochem. Biophys. Res. Commun. , vol.188 , pp. 942-948
    • Tanaka, H.1    Makino, I.2
  • 67
    • 0023913120 scopus 로고
    • The steroid and thyroid hormone receptor superfamily
    • Evans RM. The steroid and thyroid hormone receptor superfamily. Science 1988; 240: 889-95.
    • (1988) Science , vol.240 , pp. 889-895
    • Evans, R.M.1
  • 68
    • 0024545638 scopus 로고
    • Gene regulation by steroid hormones
    • Beato M. Gene regulation by steroid hormones. Cell 1989; 56: 335-44.
    • (1989) Cell , vol.56 , pp. 335-344
    • Beato, M.1
  • 69


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.