New Insights into Glucocorticoid and Mineralocorticoid Signaling: Lessons from Gene Targeting

Advances in Pharmacology

Volumn 47, Issue C, 1999, Pages 1-21

  Reichardt, Holger M ^a   Tronche, François ^a   Berger, Stefan ^a   Kellendonk, Christoph ^a   Schütz, Günther ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77956736670     PISSN: 10543589     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1054-3589(08)60108-8     Document Type: Article

References (51)

1. Barnes P.J., and Adcock I. Anti-inflammatory actions of steroids: molecular mechanisms. Trends Pharmacol. Sci. 14 (1993) 436-441
2. Beato M. Gene regulation by steroid hormones. Cell 56 (1989) 335-344
3. Beato M., Chalepakis G., Schauer M., and Slater E.P. DNA regulatory elements for steroid hormones. J. Steroid. Biocbem. 32 (1989) 737-747
4. Beato M., Herrlich P., and Schiitz G. Steroid hormone receptors: many actors in search of a plot. Cell 83 (1995) 851-857
5. + metabolism. Proc. Natl. Acad. Sci. USA 95 (1998) 9424-9429
6. Birnberg N.C., Lissitzky J.C., Hinman M., and Herbert E. Glucocorticoids regulate proopiomelanocortin gene expression in vivo at the levels of transcription and secretion. Proc. Natl. Acad. Sci. USA 80 (1983) 6982-6986
7. Caelles C., Gonzalez SanchoJ.M., and Munoz A. Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway. Genes Dev. 11 (1997) 3351-3364
8. Caldenhoven E., Liden J., Wissink S., Van de Stolpe A., Raaijmakers J., Koenderman L., Okret S., Gustafsson J.A., and Van der Saag P.T. Negative cross-talk between ReIA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids. Mol. Endocrinol. 9 (1995) 401-412
9. Chang T.J., Scher B.M., Waxman S., and Scher W. Inhibition of mouse GATA-1 function by the glucocorticoid receptor: possible mechanism of steroid inhibition of erythroleukemia cell differentiation. Mol. Endocrinol. 7 (1993) 528-542
10. Chang S.S., Grunder S., Hanukoglu A., Rosier A., Mathew P.M., Hanukoglu I., Schild L., Lu Y., Shimkets R.A., Nelson Williams C., Rossier B.C., and Lifton R.P. Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nature Genetics 12 (1996) 248-253
11. Chapman M.S., Askew D.J., Kuscuoglu U., and Miesfeld R.L. Transcriptional control of steroid-regulated apoptosis in murine thymoma cells. Mol. Endocrinol. 10 (1996) 967-978
12. Cole T.J., Blendy J.A., Monaghan A.P., Krieglstein K., Schmid W., Aguzzi A., Fantuzzi G., Hummler E., Unsicker K., and Schütz G. Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev. 9 (1995) 1608-1621
13. Couse J.F., Curtis S.W., Washburn T.F., Lindzey J., Golding T.S., Lubahn D.B., Smithies O., and Korach K.S. Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene. Mol. Endocrinol. 9 (1995) 1441-1454
14. Dieken E.S., Meese E.U., and Miesfeld R.L. nti glucocorticoid receptor transcripts lack sequences encoding the amino-terminal transcriptional modulatory domain. Mol. Cell. Biol. 10 (1990) 4574-4581
15. Fink G. Mechanism of negative and positive feedback of steroids in the hypothalamicpituitary system. In: Bittar E.E., and Bittar N. (Eds). Principles of Medical Biology (1997), JAI-Press, London 30-100
16. Funder J.W. Glucocorticoid receptors. J. Steroid. Biocbem. Mol Biol. 43 (1992) 389-394
17. Funder J.W. Mineralocorticoids, glucocorticoids, receptors and response elements. Science 259 (1993) 1132-1133
18. Funder J.W., Pearce P.T., Smith R., and Smith A.I. Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. Science 242 (1988) 583-585
19. Gaillard R.C. Neuroendocrine-immune system Interactions. The immune-hypothalamo-pituitary-adrenal axis. Trends Endo. Metab. 5 (1994) 303-309
20. Gu H., Zou Y.R., and Rajewsky K. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 73 (1993) 1155-1164
21. Heck S., Kullmann M., Gast A., Ponta H., Rahmsdorf H.J., Herrlich P., and Cato A.C. A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. Embo J. 13 (1994) 4087-4095
22. Hesen W., Karst H., Meijer O., Cole T.J., Schmid W., de Kloet E.R., Schutz G., and Joels M. Hippocampal cell responses in mice with a targeted glucocorticoid receptor gene disruption. J. Neurosci. 16 (1996) 6766-6774
23. Imai E., Miner J.N., Mitchell J.A., Yamamoto K.R., and Granner D.K. Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids. J. Biol. Chem. 268 (1993) 5353-5356
24. Joels M., and de Kloet E.R. Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems. Prog. Neurobiol. 43 (1994) 1-36
25. Jonat C., Rahmsdorf H.J., Park K.K., Cato A.C., Gebel S., Ponta H., and Herrlich P. Antitumor promotion and antünflammation: down-modulation of AP-1 (Fos/ Jun) activity by glucocorticoid hormone. Cell 62 (1990) 1189-1204
26. Kastner P., Mark M., and Chambon P. Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life?. Cell 83 (1995) 859-869
27. Kretz O., Reichardt H.M., Schutz G., and Bock R. Corticotropin-releasing hormone expression is the major target for glucocorticoid feedback-control at the hypothalamic level. Brain Research 818 (1999) 488-491
28. Lupien S.J., de Leon M., de Santi S., Convit A., Tarshish C., Nair N.P.V., Thakur M., McEwen B.S., Hauger R.L., and Meaney M.J. Cortisol level during human aging predict hippocampal atrophy and memory deficits. Nature Neurosci. 1 (1998) 69-73
29. Lydon J.P., DeMayo F.J., Funk C.R., Mani S.K., Hughes A.R., Montgomery Jr. C.A., Shyamala G., Conneely O.M., and O'Malley B.W. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev. 9 (1995) 2266-2278
30. Magarinos A.M., McEwen B.S., Flugge G., and Fuchs E. Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. J. Neurosci. 16 (1996) 3534-3540
31. McEwen B.S., and Sapolsky R.M. Stress and cognitive function. Curr. Opin. Neurobiol. 5 (1995) 205-216
32. McGaugh J.L., Cahill L., and Roozendaal B. Involvement of the amygdala in memory storage: interaction with other brain systems. Proc. Natl. Acad. Sci. USA 93 (1996) 13508-13514
33. Miller W.L., and Blake Tyrrel J. The adrenal cortex. In: Felig P., Baxter J.D., and Frohman L.A. (Eds). Endocrinology and Metabolism (1995), McGraw-Hill, New York 555-711
34. Oitzl M.S., de Kloet E.R., Joels M., Schmid W., and Cole T.J. Spatial learning deficits in mice with a targeted glucocorticoid receptor gene disruption. Eur. J. Neurosci. 9 (1997) 2284-2296
35. Pearce D., and Yamamoto K.R. Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element. Science 259 (1993) 1161-1165
36. Reichardt H.M., and Schutz G. Feedback control of glucocorticoid production is established during fetal development. Mol. Med. 2 (1996) 735-744
37. Reichardt H.M., Kaestner K.H., Tuckermann J., Kretz O., Gass P., Schmid W., Herrlich P., Angel P., and Schutz G. DNA binding of the glucocorticoid receptor is not essential for survival. Cell 93 (1998) 531-541
38. Rogatsky I., Logan S.K., and Garabedian M.J. Antagonism of glucocorticoid rceptor transcriptional activation by the c-Jun N-terminal kinase. Proc. Natl. Acad. Sci. USA 95 (1998) 2050-2055
39. Ross M.E., Evinger M.J., Hyman S.E., Carroll J.M., Mucke L., Comb M., Reis D.J., Joh T.H., and Goodman H.M. Identification of a functional glucocorticoid response element in the phenylethanolamine N-methyltransferase promoter using fusion genes introduced into chromaffin cells in primary culture. J. Neurosci. 10 (1990) 520-530
40. Rossier C.R., and Palmer L.G. Mechanisms of aldosterone action on sodium and potassium transport. In: Seldin D.W., and Giebisch G. (Eds). The Kidney: Physiology and Pathophysiology (1992), Raven, New York 1373-1409
41. Ruppert S., Boshart M., Bosch F.X., Schmid W., Fournier R.E., and Schütz G. Two genetically defined trans-acting loci coordinately regulate overlapping sets of liver-specific genes. Cell 61 (1990) 895-904
42. Sapolsky R.M. Why stress is bad for your brain. Science 273 (1996) 749-750
43. Schüle R., Rangarajan P., Kliewer S., Ransone L.J., Bolado J., Yang N., Verma I.M., and Evans R.M. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 62 (1990) 1217-1226
44. Sloviter R.S., Valiquette G., Abrams G.M., Ronk E.C., Sollas A.L., Paul L.A., and Neubort S. Selective loss of hippocampal granule cells in the mature rat brain after adrenalectomy. Science 243 (1989) 535-538
45. Stöcklin E., Wissler M., Gouilleux F., and Groner B. Functional interactions between Stat 5 and the glucocorticoid receptor. Nature 383 (1996) 726-728
46. Subbarayan V., Kastner P., Mark M., Dierich A., Gorry P., and Chambon P. Limited specificity and large overlap of the functions of the mouse RAR gamma 1 and RAR gamma 2 isoforms. Mech. Dev. 66 (1997) 131-142
47. Thomas K.R., and Capecchi M.R. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51 (1987) 503-512
48. Verrey F. Transcriptional control of sodium transport in tight epithelial by adrenal steroids. J. Membr. Biol. 144 (1995) 93-110
49. Wessely O., Deiner E., Beug H., and von Lindern M. The glucocorticoid receptor is a key regulator of the decision between self-renewal and differentiation in erythroid progenitors. EMBO J. 16 (1997) 267-280
50. Wong D.L., Siddall B., and Wang W. Hormonal control of rat adrenal phenylethanolamine N-methyltransferase. Enzyme activity, the final critical pathway. Neuropsychophar-macology 13 (1995) 223-234
51. Yang Yen H.F., Chambard J.C., Sun Y.L., Smeal T., Schmidt T.J., Drouin J., and Karin M. Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62 (1990) 1205-1215