Identification of Two Topologically Independent Domains in RAG1 and Their Role in Macromolecular Interactions Relevant to V(D)J Recombination

Journal of Biological Chemistry

Volumn 276, Issue 40, 2001, Pages 37093-37101

  Arbuckle, Janeen L ^a   Fauss, LeAnn J ^a   Simpson, Rosemarie ^a,c   Ptaszek, Leon M ^b,d   Rodgers, Karla K ^a  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c SANGAMO BIOSCIENCES INC   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CLONING; DIMERIZATION; DNA; MACROMOLECULES;

RECOMBINATION SIGNAL SEQUENCE (RSS);

PROTEINS;

CORE PROTEIN; DNA; HEPTAMER; NONAMER; OLIGOMER; RAG1 PROTEIN; RAG2 PROTEIN; SIGNAL PEPTIDE; UNCLASSIFIED DRUG; DNA POLYMERASE; HOMEODOMAIN PROTEIN; RAG 1 PROTEIN; RAG-1 PROTEIN; RECOMBINASE; TRYPSIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL DOMAIN; CENTRAL DOMAIN; DIMERIZATION; DNA CLEAVAGE; ENZYME ACTIVE SITE; ESCHERICHIA COLI; GENETIC RECOMBINATION; IMMUNOGLOBULIN V(D)J RECOMBINATION; MACROMOLECULE; MOLECULAR CLONING; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; RECOMBINATION SIGNAL SEQUENCE; ANIMAL; CHEMISTRY; GENE REARRANGEMENT; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE;

ESCHERICHIA COLI;

ANIMALS; BINDING SITES; DIMERIZATION; DNA; DNA NUCLEOTIDYLTRANSFERASES; GENE REARRANGEMENT; HOMEODOMAIN PROTEINS; MICE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; TRYPSIN; VDJ RECOMBINASES;

EID: 0035813101     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M105988200     Document Type: Article

References (46)

1. Fugmann, S. D., Lee, A. I., Shockett, P. E., Villey, I. J., and Schatz, D. G. (2000) Annu. Rev. Immunol. 18, 495-527
2. McBlane, J. F., van Gent, D. C., Ramsden, D. A., Romeo, C., Cuomo, C. A., Gellert, M., and Oettinger, M. A. (1995) Cell 83, 387-395
3. van Gent, D. C., Mizuuchi, K., and Gellert, M. (1996) Science 271, 1592-1594
4. Eastman, Q. M., and Schatz, D. G. (1997) Nucleic Acids Res. 25, 4370-4378
5. West, R. B., and Lieber, M. R. (1998) Mol. Cell. Biol. 18, 6408-6415
6. Yu, K., and Lieber, M. R. (2000) Mol. Cell. Biol. 20, 7914-7921
7. Grawunder, U., Zimmer, D., Fugmann, S., Schwarz, K., and Lieber, M. R. (1998) Mol. Cell 2, 477-484
8. Grawunder, U., Zimmer, D., Kulesza, P., and Lieber, M. R. (1998) J. Biol. Chem. 273, 24708-24714
9. Agrawal, A., and Schatz, D. G. (1997) Cell 89, 43-53
10. Hiom, K., and Gellert, M. (1998) Mol. Cell 1, 1011-1019
11. Besmer, E., Mansilla-Soto, J., Cassard, S., Sawchuk, D. J., Brown, G., Sadofsky, M., Lewis, S. M., Nussenzweig, M. C., and Cortes, P. (1998) Mol. Cell 2, 817-828
12. Shockett, P. E., and Schatz, D. G. (1999) Mol. Cell. Biol. 19, 4159-4166
13. Santagata, S., Besmer, E., Villa, A., Bozzi, F., Allingham, J. S., Sobacchi, C., Haniford, D. B., Vezzoni, P., Nussenzweig, M. C., Pan, Z.-Q., and Cortes, P. (1999) Mol. Cell 4, 935-947
14. Moshous, D., Callebaut, I., de Chasseval, R., Corneo, B., Cavazzana-Calvo, M., Le Deist, F., Tezcan, I., Sanal, O., Bertrand, Y., Philippe, N., Fischer, A., and de Villartay, J.-P. (2001) Cell 105, 177-186
15. Grawunder, U., and Harfst, E. (2001) Curr. Opin. Immunol. 13, 186-194
16. Spanopoulou, E., Zaitseva, F., Wang, F.-H., Santagata, S., Baltimore, D., and Panayotou, G. (1996) Cell 87, 263-276
17. Difilippantonio, M. J., McMahan, C. J., Eastman, Q. M., Spanopoulou, E., and Schatz, D. G. (1996) Cell 87, 253-262
18. Swanson, P. C., and Desiderio, S. (1998) Immunity 9, 115-125
19. Eastman, Q. M., Villey, I. J., and Schatz, D. G. (1999) Mol. Cell. Biol. 19, 3788-3797
20. Me, X., Bailin, T., and Sadofsky, M. J. (1999) J. Biol. Chem. 274, 7025-7031
21. Rodgers, K. K., Villey, I. J., Ptaszek, L., Corbett, E., Schatz, D. G., and Coleman, J. E. (1999) Nucleic Acids Res. 27, 2938-2946
22. Aidinis, V., Bonaldi, T., Beltrame, M., Santagata, S., Bianchi, M. E., and Spanopoulou, E. (1999) Mol. Cell. Biol. 19, 6532-6542
23. Kim, D. R., Dai, Y., Mundy, C. L., Yang, W., and Oettinger, M. A. (1999) Genes Dev. 13, 3070-3080
24. Fugmann, S. D., Villey, I. J., Ptaszek, L. M., and Schatz, D. G. (2000) Mol. Cell 5, 97-107
25. Landree, M. A., Wibbenmeyer, J. A., and Roth, D. B. (1999) Genes Dev. 13, 3059-3069
26. Rice, P. A., and Baker, T. A. (2001) Nat. Struct. Biol. 8, 302-307
27. Santagata, S., Aidinis, V., and Spanopoulou, E. (1998) J. Biol. Chem. 273, 16325-16331
28. Spurlino, J. C., Lu, G. Y., and Quiocho, F. A. (1991) J. Biol. Chem. 266, 5202-5219
29. Nagawa, F., Ishiguro, K.-I., Tsuboi, A., Yoshida, T., Ishikawa, A., Takemori, T., Otsuka, A. J., and Sakano, H. (1998) Mol. Cell. Biol. 18, 655-663
30. Haren, L., Ton-Hoang, B., and Chandler, M. (1999) Annu. Rev. Microbiol. 53, 245-281
31. Bolland, S., and Kleckner, N. (1996) Cell 84, 223-233
32. Aidinis, V., Dias, D. C., Gomez, C. A., Bhattacharyya, D., Spanopoulou, E., and Santagata, S. (2000) J. Immunol. 164, 5826-5832
33. McMahan, C. J., Sadofsky, M. J., and Schatz, D. G. (1997) J. Immunol. 158, 2202-2210
34. Swanson, P. C., and Desiderio, S. (1999) Mol. Cell. Biol. 19, 3674-3683
35. Akamatsu, Y., and Oettinger, M. A. (1998) Mol. Cell. Biol. 18, 4670-4678
36. Rodgers, K. K., Bu, Z., Fleming, K. G., Schatz, D. G., Engelman, D. M., and Coleman, J. E. (1996) J. Mol. Biol. 260, 70-84
37. Bellon, S. F., Rodgers, K. K., Schatz, D. G., Coleman, J. E., and Steitz, T. A. (1997) Nat. Struct. Biol. 4, 586-591
38. Sadofsky, M. J., Hesse, J. E., van Gent, D. C., and Gellert, M. (1995) Genes Dev. 9, 2193-2199
39. Kale, S. B., Landree, M. A., and Roth, D. B. (2001) Mol. Cell. Biol. 21, 459-466
40. Mo, X., Bailin, T., and Sadofsky, M. J. (2001) Mol. Cell. Biol. 21, 2038-2047
41. Swanson, P. C. (2001) Mol. Cell. Biol. 21, 449-458
42. Davies, D. R., Goryshin, I. Y., Reznikoff, W. S., and Rayment, I. (2000) Science 289, 77-85
43. Sawchuk, D. J., Weis-Garcia, F., Malik, S., Besmer, E., Bustin, M., Nussenzweig, M. C., and Cortes, P. (1997) J. Exp. Med. 185, 2025-2032
44. van Gent, D. C., Hiom, K., Paull, T. T., and Gellert, M. (1997) EMBO J. 16, 2665-2670
45. Kwon, D., Chalmers, R. M., and Kleckner, N. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 8234-8238
46. Tung, C. S., and Soumpasis, D. M. (1995) J. Biomol. Struct. Dyn. 13, 577-582