Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders

Journal of Medicinal Chemistry

Volumn 44, Issue 16, 2001, Pages 2536-2543

  Baraldi, P G ^a   Balboni, G ^a   Pavani, M G ^a   Spalluto, G ^a   Tabrizi, M A ^a   De Clercq, E ^b   Balzarini, J ^b   Bando, T ^c   Sugiyama, H ^c   Romagnoli, R ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 [1 METHYL 4 [1 METHYL 3 [6 (1 BENZYL 4 CHLOROMETHYL 8 HYDROXY 4,5 DIHYDRO 6H PYRROLE[3,2 E] 1H INDAZOLE]CARBOXYLPYRAZOLE 5 CARBOXAMIDO]PROPIONAMIDINE; 3 [1 METHYL 4 [1 METHYL 3 [6 (3 METHYL 4 CHLOROMETHYL 8 HYDROXY 4,5 DIHYDRO 6H PYRROLE[3,2 E] 1H INDAZOLE]CARBOXYLPYRAZOLE 5 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PROPIONAMIDINE; 3 [1 METHYL 4 [1 METHYL 4 [1 METHYL 3 [6 (1 BENZYL 4 CHLOROMETHYL 8 HYDROXY 4,5 DIHYDRO 6H PYRROLE[3,2 E] 1H INDAZOLE]CARBOXYPYRAZOLE 5 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PROPIONAMIDINE; 3 [1 METHYL 4 [1 METHYL 4 [1 METHYL 3 [6 (3 METHYL 4 CHLOROMETHYL 8 HYDROXY 4,5 DIHYDRO 6H PYRROLE[3,2 E] 1H INDAZOLE]CARBOXYPYRAZOLE 5 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PROPIONAMIDINE; 3 [1 METHYL 4 [1 METHYL 4 [1 METHYL 4 [1 METHYL 3 [6 (1 BENZYL 4 CHLOROMETHYL 8 HYDROXY 4,5 DIHYDRO 6H PYRROLE[3,2 E] 1H INDAZOLE]CARBOXYPYRAZOLE 5 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PROPIONAMIDINE; 3 [1 METHYL 4 [1 METHYL 4 [1 METHYL 4 [1 METHYL 3 [6 (3 METHYL 4 CHLOROMETHYL 8 HYDROXY 4,5 DIHYDRO 6H PYRROLE[3,2 E] 1H INDAZOLE]CARBOXYPYRAZOLE 5 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PROPIONAMIDE; ALKYLATING AGENT; ANTINEOPLASTIC AGENT; CYCLOPROPYLPYRROLOINDOLE; INDOLE DERIVATIVE; POLYPYRROLE; PYRAZOLE DERIVATIVE; RACHELMYCIN; RACHELMYCIN DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA ALKYLATION; DNA SEQUENCE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG DNA BINDING; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR MODEL; MOUSE; NONHUMAN; VACCINIA VIRUS;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; ANTIVIRAL AGENTS; DNA; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDAZOLES; INDOLES; LEUCOMYCINS; MICE; MODELS, MOLECULAR; PYRAZOLES; PYRROLES; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; WATER;

EID: 0035797366     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0108404     Document Type: Article

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