5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles: Relationships between structure and cytotoxicity for analogues bearing different DNA minor groove binding subunits

Journal of Medicinal Chemistry

Volumn 42, Issue 17, 1999, Pages 3400-3411

  Atwell, Graham J ^a   Milbank, Jared J B ^a   Wilson, William R ^a   Hogg, Alison ^a   Denny, William A ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 1 (CHLOROMETHYL) 3 [4 METHOXYCINNAMOYL] 1,2 DIHYDRO 3H BENZ[E]INDOLE; ALKYLATING AGENT; CARBOXYLIC ACID; INDOLE DERIVATIVE; NITRO DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL REACTION; DNA DRUG COMPLEX; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; REACTION ANALYSIS; REDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; INDOLES; INHIBITORY CONCENTRATION 50; MALE; MICE; MICE, INBRED C3H; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0033606952     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990136b     Document Type: Article

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