CC-1065/duocarmycin and bleomycin A2 hybrid agents: Lack of enhancement of DNA alkylation by attachment to noncomplementary DNA binding subunits

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 2, 1997, Pages 233-243

  Boger, Dale L ^a   Han, Nianhe ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN A2; BLEOMYCIN DERIVATIVE; RACHELMYCIN; RACHELMYCIN DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA ALKYLATION; DNA BINDING; DNA STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; IN VITRO STUDY; LEUKEMIA L 1210; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE SEQUENCE; STRUCTURE ACTIVITY RELATION; ULTRAVIOLET RADIATION;

ALKYLATION; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; CATTLE; DNA; INDOLES; LEUCOMYCINS; LEUKEMIA L1210; MAGNETIC RESONANCE SPECTROSCOPY; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT;

ANIMALIA;

EID: 0031081385     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(96)00237-4     Document Type: Article

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65. 18. Natrajan, A.; Hecht, S. M. In Molecular Aspects of Anticancer Drug-DNA Interactions; Neidle, S.; Waring, M. J., Eds.; CRC Press: Boca Raton, 1994; Vol. 2, p 197; Kane, S. A.; Hecht, S. M. In Progress in Nucleic Acids Research Molecular Biology; Cohn, W. E.; Moldave, K., Eds.; Academic Press: San Diego, 1994; Vol. 49, p 313; Ohno, M.; Otsuka, M. In Recent Progress in the Chemical Synthesis of Antibiotics; Lukacs, G.; Ohno, M., Eds.; Springer-Verlag: New York, 1990; p 387; Dedon, P. C.; Goldberg, I. H. Chem. Res. Toxicol. 1992, 5, 311; Petering, D. H.; Byrnes, R. W.; Antholine, W. E. Chem.-Biol. Interact. 1990, 73, 133; Stubbe, J.; Kozarich, J. W. Chem. Rev. 1987, 87, 1107; Hecht, S. M. Acc. Chem. Res. 1986, 19, 383. Sugiura, Y.; Takita, T.; Umezawa, H. Metal Ions Biol. Syst. 1985, 19, 81; Twentyman, P. R. Pharmacol. Ther. 1984, 23, 417; Povirk, L. F. In Molecular Aspects of Anti-Cancer Drug Action; Neidle, S.; Waring, M. J., Eds.; MacMillian: London, 1983; Bleomycin: Chemical, Biochemical and Biological Aspects; Hecht, S. M., Ed.; Springer-Verlag: New York, 1979; Umezawa, H. In Bleomycin: Current Status and New Developments; Carter, S. K.; Crooke, S. T.; Umezawa, H., Eds.; Academic Press: New York, 1978.
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