High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA

Journal of Molecular Biology

Volumn 272, Issue 2, 1997, Pages 237-252

  Eis, Peggy S ^a   Smith, Jarrod A ^a   Rydzewski, Jan M ^a   Case, David A ^a   Boger, Dale L ^a   Chazin, Walter J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

DNA alkylation; DNA minor groove binding; Duocarmycin; NMR; Shape dependent catalysis

Indexed keywords

ALKYLATING AGENT; DOUBLE STRANDED DNA; DUOCARMYCIN A;

ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DNA ALKYLATION; DNA CONFORMATION; DRUG BINDING SITE; HYDROPHOBICITY; LIGAND BINDING; MOLECULAR DYNAMICS; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0030760674     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1997.1223     Document Type: Article

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