Alteration of drug biotransformation and elimination during infection and inflammation

Pharmacology and Therapeutics

Volumn 92, Issue 2-3, 2001, Pages 147-163

  Renton, Kenneth W ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Cytochrome P450; Cytokines; Infection; Inflammation

Indexed keywords

7 ETHOXYCOUMARIN; CARRAGEENAN; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2B; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A2; DEBRISOQUINE; HERNIARIN; HEXOBARBITAL; INTERLEUKIN 1; NITRIC OXIDE; PARACETAMOL; PENTOBARBITAL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHENAZONE; PHENYLBUTAZONE; RECOMBINANT ALPHA INTERFERON; RECOMBINANT BETA INTERFERON; RECOMBINANT GAMMA INTERFERON; SUPEROXIDE; THEOPHYLLINE; TILORONE; UNINDEXED DRUG; VERAPAMIL; XANTHINE OXIDASE; ZOXAZOLAMINE;

CENTRAL NERVOUS SYSTEM; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG CLEARANCE; DRUG ELIMINATION; DRUG METABOLISM; DRUG TRANSFORMATION; FEVER; FOOD; GENOTYPE; HUMAN; INFECTION; INFLAMMATION; MOLECULAR MECHANICS; NONHUMAN; OXIDATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REVIEW; STRESS;

ANIMALS; BIOTRANSFORMATION; CYTOCHROME P-450 ENZYME SYSTEM; CYTOKINES; DOWN-REGULATION; DRUG THERAPY; HUMANS; INFECTION; INFLAMMATION; LIVER; PHARMACOKINETICS;

EID: 0035726732     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(01)00165-6     Document Type: Review

References (215)

1. Transforming growth factor-beta 1 down-regulates basal and polycyclic aromatic hydrocarbon-induced cytochromes P-450 1A1 and 1A2 in adult human hepatocytes in primary culture
2. Interleukin-1 beta antagonizes phenobarbital induction of several major cytochromes P450 in adult rat hepatocytes in primary culture
3. The effects of acute falciparum malaria on the disposition of caffeine and the comparison of saliva and plasma-derived pharmacokinetic parameters in adult Nigerians
4. The chronic administration of nicotine induces cytochrome P450 in rat brain
5. Modulatory effect of hyperthermia on hepatic microsomal cytochrome P450 in mice
6. The duration of induction and species influences the downregulation of cytochrome P450 by the interferon inducer polyinosinic acid-polycytidylic acid
7. Transient alteration of theophylline half-life: Possible association with Herpes simplex infection
8. Pertussis toxin-induced alterations of murine hepatic drug metabolism following administration of diphtheria and tetanus toxoids and pertussis vaccine adsorbed
9. Alterations of hepatic drug metabolism in mice following infection with murine retrovirus LP-BM5
10. Hepatic cytochrome P450 and related drug biotransformation during an outbreak of mouse hepatitis virus in a colony of Swiss BALB/c mice
11. Mechanism of hepatic cytochrome P450 modulation during Listeria monocytogenes in mice
12. Factors involved in the down-regulation of cytochrome P450 during Listeria monocytogenes infection
13. Brain injury and inflammation, a putative role for TNF-alpha
14. Depression of murine hepatic mixed function oxidase during infection with Listeria monocytogenes
15. Factors involved in the depression of hepatic mixed function oxidase during infections with Listeria monocytogenes
16. Possible mechanisms of alteration in the capacities of carcinogen metabolizing enzymes during schistosomiasis and their role in bladder cancer induction
17. Altered distribution of debrisoquine oxidation phenotypes in patients with systemic lupus erythematosus
18. Effect of nifedipine on the elimination of theophylline in the rabbit subjected to hypoxia or to an inflammatory reaction
19. Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent
20. Interleukin-1 beta suppresses the induction of P4501A1 and P4501A2 mRNAs in isolated hepatocytes
21. Down-regulation of P4501A1 and P4501A2 mRNA expression in isolated hepatocytes by oxidative stress
22. Depression of the N-demethylation of erythromycin, azithromycin, clarithromycin and clindamycin in murine Toxoplasma infection
23. Suppression of intestinal and hepatic cytochrome P4503A in murine Toxoplasma infection. Effects of N-acetylcysteine and N(G)-monomethyl-L-arginine on the hepatic suppression
24. Reconstitution of the brain mixed function oxidase system: Purification of NADPH-cytochrome P450 reductase and partial purification of cytochrome P450 from whole rat brain
25. Transcriptional activation of CYP2C, MxA and Fas in sudden infant death syndrome
26. Consequences of challenge infections with Fasciola hepatica on rat liver P450-dependent metabolism of sex hormones
27. Cytochrome P450 inactivation by serum from humans with a viral infection and serum from rabbits with a turpentine-induced inflammation: The role of cytokines
28. Changes of antipyrine pharmacokinetics during influenza and after administration of interferon-alpha and -beta
29. Differential effects of interleukin-1beta, interleukin-2, and interferon-gamma on the inducible expression of CYP 1A1 and CYP 1A2 in cultured rabbit hepatocytes
30. Comparative effects of cytokines on constitutive and inducible expression of the gene encoding for the cytochrome P450 3A6 isoenzyme in cultured rabbit hepatocytes: Consequences on progesterone 6beta- hydroxylation
31. Comparison of hepatic and renal drug-metabolising enzyme activities in sheep given single or two-fold challenge infections with fasciola hepatica
32. Modulation of constitutive and inducible hepatic cytochrome(s) P-450 by interferon beta in mice
33. Role of nitric oxide in the cytokine-mediated regulation of cytochrome P-450
34. Increased susceptibility to pentobarbital following mouse cytomegalovirus
35. Cytokines in inflammation
36. Effect of Schistosoma mansoni infection on the hepatic drug-metabolizing capacity of mice
37. Xenobiotic-metabolizing enzymes in carp (Cyprinus carpio) liver, spleen, and head kidney following experimental Listeria monocytogenes infection
38. Altered theophylline pharmacokinetics during acute respiratory viral illness
39. Suppression of the constitutive expression of cytochrome P-450 2C11 by cytokines and interferons in primary cultures of rat hepatocytes: Comparison with induction of acute-phase genes and demonstration that CYP2C11 promoter sequences are involved in the suppressive response to interleukins 1 and 6
40. Effects of interleukin-6 on cytochrome P450-dependent mixed-function oxidases in the rat
41. Acute-phase response, interleukin-6, and alteration of cyclosporine pharmacokinetics
42. In-vitro biotransformation of antipyrine, lignocaine and propranolol in the liver of rats with turpentine-induced inflammation
43. Distinct time courses of increase in cytochromes P450 1A2, 2A5 and glutathione S-transferases during the progressive hepatitis associated with Helicobacter hepaticus
44. The effect of chronic retrovirus infection and immune dysfunction on the P-450-mediated activation of acetaminophen in mouse liver microsomes
45. Differential effect of cytokines on the phenobarbital or 3-methylcholanthrene induction of P450 mediated monooxygenase activity in cultured rat hepatocytes
46. Theophylline pharmacokinetics during respiratory viral infection
47. Effect of PR-8 viral respiratory infection on benzo(a)pyrene hydroxylase activity in BALB/c mice
48. Interferon down regulates the male-specific cytochrome P450IIIA2 in rat liver
49. Interferon suppresses erythromycin metabolism in rats and human subjects
50. Dissociation of xanthine oxidase induction and cytochrome P450 depression
51. Regulation of cytochrome P-4501A and cytochrome P-4502E induction in the rat
52. Molecular cloning and regulation of expression of two novel mouse CYP4F genes: Expression in peroxisome proliferator-activated receptor alpha-deficient mice upon lipopolysaccharide and clofibrate challenges
53. Enhanced metabolic activation of chemical hepatocarcinogens in woodchucks infected with hepatitis B virus
54. Cytochrome P4501A1 and cytochrome P4501A2 are downregulated at both transcriptional and post-transcriptional levels by conditions resulting in interferon-alpha/beta induction
55. Modulation of rat hepatic CYP3A1 induction by the interferon inducer polyinosinic acid-polycytidylic acid (polyic)
56. Interferon-mediated changes in the expression of CYP1A1 in human B lymphoblastoid (AHH-1 TK+/-) cells
57. Proinflammatory cytokines
58. Nitric oxide-mediated inhibition of cytochrome P450 by interferon-gamma in human hepatocytes
59. Effects of subchronic treatment with natural human interferons on antipyrine clearance and liver function in patients with chronic hepatitis
60. Effect of honeybee (Apis mellifera) venom on the course of adjuvant-induced arthritis and depression of drug metabolism in the rat
61. Hepatic microsomal enzymes in S. mansoni infected mice: II. Effect of duration of infection and lindane administration on aminopyrine demethylase and aniline hydroxylase
62. Effects of etiocholanolone-induced fever on plasma antipyrine half-lives and metabolic clearance
63. Depression of the hepatic cytochrome P450 by an acute inflammatory reaction: Characterization of the nature of mediators in human and rabbit serum, and in the liver
64. Down-regulation of the hepatic cytochrome P450 by an acute inflammatory reaction: Implication of mediators in human and animal serum and in the liver
65. Role of reactive oxygen intermediates in the decrease of hepatic cytochrome P450 activity by serum of humans and rabbits with an acute inflammatory reaction
66. Hepatic drug-metabolizing enzyme activities and anti-inflammatory potency of hydrocortisone in rats with granulomatous inflammation
67. Interleukin-1 beta differentially represses drug-metabolizing enzymes in arthritic female rats
68. Theophylline pharmacokinteics and respiratory infections
69. Interferon action: RNA cleavage pattern of a (2′-5′)oligoadenylate-dependent endonuclease
70. The effect of fever on antipyrine metabolism in children
71. Suppression of cytochrome P450IA1 by interleukin-6 in human HepG2 hepatoma cells
72. Interleukin-6 down regulates the expression of transcripts encoding cytochrome P450 1A1, 1A2 and III3A in human hepatoma cells
73. Impairment of drug metabolism by the liver in experimental fascioliasis in the rat
74. Fasciola hepatica: Liver microsomal membrane functions in host rat
75. Enhanced xanthine oxidase activity in mice treated with interferon and interferon inducers
76. Role of reactive oxygen intermediates in the interferon-mediated depression of hepatic drug metabolism and protective effect of N-acetylcysteine in mice
77. Role of interleukin-1 in the depression of liver drug metabolism by endotoxin
78. Evolution of the P450 gene superfamily: Animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation
79. Depression of cytochrome P-450 and alterations of protein metabolism in mice treated with the interferon inducer polyriboinosinic acid X polyribocytidylic acid
80. Changes in serum anticonvulsant levels with febrile illness in children with epilepsy
81. Viral induced changes in theophylline handling in children
82. The role of nitric oxide generation in interferon-evoked cytochrome P450 down-regulation
83. Modulation of drug metabolism in infectious and inflammatory diseases
84. Suppression of CYP2C11 gene transcription by interleukin-1 mediated by NF-kappaB binding at the transcription start site
85. Central interleukin-1B enhances splenic sympathetic nerve activity in rats
86. Induction and regulation of cytochrome P450 K-5 (lauric acid hydroxylase) in rat renal microsomes by starvation
87. Modulation of zoxazolamine metabolism in carrageenan-induced inflammation in rats
88. Reduced drug metabolism in isolated hepatocytes from adjuvant arthritic rats
89. Lack of correlation between induction of adjuvant arthritis and changes in metabolism and disposition of phenylbutazone in rats
90. Effects of interferon on theophylline pharmacokinetics and metabolism
91. Enhanced phenobarbital induction of liver microsomal drug metabolizing enzymes in mice infected with murine hepatitis virus
92. Cytochrome P450 in rat astrocytes in vivo and in vitro: Intracellular localization and induction by phenytoin
93. Nitric oxide differentially affects constitutive cytochrome P450 isoforms in rat liver
94. Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants
95. Role of nitric oxide in the inhibition of cytochrome P450 in the liver of mice infected with Chlamydia trachomatis
96. Overexpression of cytochrome P-450 isoforms involved in aflatoxin B1 bioactivation in human liver with cirrhosis and hepatitis
97. Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes
98. Effect of malaria infection and endotoxin-induced fever on the metabolism of antipyrine and metronidazole in the rat
99. Decrease in theophylline clearance causing toxicity during viral epidemics
100. The cytochrome P-450-dependent mono-oxygenase system of the liver and interleukin-1 production by the macrophages in adjuvant arthritis in rats under the influence of beta-carotene
101. Inhibition of the cytochrome P-450-dependent monooxygenase system of the liver in rats with adjuvant arthritis
102. Altered theophylline clearance during an influenza outbreak
103. Effects of interleukin 1 alpha on the activities and gene expressions of the cytochrome P450IID subfamily
104. Altered patterns of drug metabolism in patients with acquired immunodeficiency syndrome
105. Decrease in activity of the drug metabolizing enzymes of the rat following the administration of tilorone hydrochloride
106. Fasciola hepatica infection in sheep: Changes in liver metabolism
107. Effects of bacterial lipopolysaccharide on phenobarbital-induced CYP2B expression in mice
108. Endotoxin pretreatment protects against the hepatotoxicity of acetaminophen and carbon tetrachloride: Role of cytochrome P450 suppression
109. The pharmacology and toxicology of interferons. An overview
110. Role of xanthine oxidase in the interferon mediated depression of cytochrome P450 system in mice
111. Reduced levels of mutagen processing potential in the Schistosoma japonicum-infected mouse liver
112. Decreased dromotropic response to verapamil despite pronounced increased drug concentration in rheumatoid arthritis
113. Effects of malarial infection on host microsomal drug-metabolizing enzymes
114. Characterization of cyp4a induction in rat liver by inflammatory stimuli: Dependence on sex, strain, and inflammation-evoked hypophagia
115. Infection (Actinobacillus pleuropneumoniae)-mediated suppression of oxidative hepatic drug metabolism and cytochrome P4503A mRNA levels in pigs
116. Differential effect of pentoxifylline on lipopolysaccharide-induced downregulation of cytochrome P450
117. A lipopolysaccharide-induced acute phase response in the pig is associated with a decrease in hepatic cytochrome P450-mediated drug metabolism
118. Suppression of cytochrome P450- and UDP glucuronosyl transferase-dependent enzyme activities by proinflammatory cytokines and possible role of nitric oxide in primary cultures of pig hepatocytes
119. Decrease in brain cytochrome P450 enzyme activities during infection and inflammation of the central nervous system
120. Induced expression of CYP2A5 in inflamed trematode-infested mouse liver
121. The effect of IFN-alpha-Con1 on hepatic cytochrome P-450 and protein synthesis and degradation in hepatic microsomes
122. A role for xanthine oxidase in the loss of cytochrome P-450 evoked by interferon
123. Induction and depression of cytochrome P-450-dependent mixed-function
124. Influence of various purified interferons on effects of drugs in mice
125. Modified expression of steroid 5 alpha-reductase as well as aromatase, but not cholesterol side-chain cleavage enzyme, in the reproductive system of male mice during (Taenia crassiceps) cysticercosis
126. Down-regulation of cytochrome P450 1A1 gene promoter by oxidative stress - Critical contribution of nuclear factor 1
127. Suppression of constitutive cytochrome P-450 gene expression in livers of rats undergoing an acute phase response to endotoxin
128. Suppression of P450IIC12 gene expression and elevation of actin messenger
129. Regulation of cytochromes P450 during inflammation and infection
130. Regulation of cytochrome P450 by inflammatory mediators: Why and how?
131. Pretranslational suppression of cytochrome P-450h (IIC11) gene expression in rat liver after administration of interferon inducers
132. Selective suppression of cytochrome P-450 gene expression by interleukins 1 and 6 in rat liver
133. Effect of carrageenan-induced granuloma on hepatic cytochrome P-450 isozymes in rats
134. Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture
135. Time-dependent effects of Klebsiella pneumoniae endotoxin on hepatic drug-metabolizing enzyme activity in rats
136. Pretranslational down-regulation of cytochromes P450 2C11 and 3A2 in male rat liver by tumor necrosis factor α
137. Intensity of Schistosoma mansoni infection determines alterations in hepatic drug metabolism
138. Modulation of cytochrome P450 by inflammation in astrocytes
139. The role of cytokines in the depression of CYP1A activity using cultured astrocytes as an in vitro model of inflammation in the CNS
140. The role of cytokines in the lipopolysaccharide evoked depression of cytochrome P450 in the brain and liver
141. Depression of drug metabolizing activity in human liver by interferon-a
142. Genotype and phenotype of cytochrome P450 2D6 in human immunodeficiency virus-positive patients and patients with acquired immunodeficiency syndrome
143. The suppression by lipopolysaccharide of cytochrome P450-dependent renal vasodilation in the rat is mediated by nitric oxide
144. Use of a novel real-time quantitative reverse transcription-polymerase chain reaction method to study the effects of cytokines on cytochrome P450 mRNA expression in mouse liver
145. The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity
146. Effects of three recombinant human leukocyte interferons on drug metabolism in mice
147. Hepatitis A impairs the function of human hepatic CYP2A6 in vivo
148. Promoter function and the role of cytokines in the transcriptional regulation of rabbit CYP2E1 and CYP2E2
149. Elimination and distribution of phenylbutazone in rats during the course of adjuvant-induced arthritis
150. Macrophages and inflammation in the central nervous system
151. Depression of cytochrome P-450-dependent drug biotransformation in hepatocytes after the activation of the reticuloendothelial system by dextran sulfate
152. Kupffer cell factor mediated depression of hepatic parenchymal cell cytochrome P-450
153. Inflammation-induced decrease in hepatic cytochrome P450 in conscious rabbits is accompanied by an increase in hepatic oxidative stress
154. Influenza virus-induced alterations of cytochrome P-450 enzyme activities following exposure of mice to coal and diesel particulates
155. Interaction between duck hepatitis virus and DDT in ducks
156. Altered theophylline kinetics
157. The deleterious effect of Bordetella pertussis vaccine and poly(rI.rC) on the metabolism and disposition of phenytoin
158. Regulation of hepatic cytochrome P450 during infectious disease
159. Depression of hepatic cytochrome P-450-dependent monooxygenase systems with administered interferon inducing agents
160. Depression of the hepatic cytochrome P-450 mono-oxygenase system by administered tilorone (2,7-bis(2-(diethylamino)ethoxy)fluoren-9-one dihydrochloride)
161. Hepatic and central nervous system cytochrome P450 are down-regulated during lipopolysaccharide-evoked localized inflammation in brain
162. Effects of polyribonoinosinic acid polyribocytidylic acid and a mouse interferon preparation on cytochrome P-450-dependent monooxygenase systems in cultures of primary mouse hepatocytes
163. Suppression of the inductive effects of phenobarbital and 3-methylcholanthrene on ascorbic acid synthesis and hepatic cytochrome P-450-linked monooxygenase systems by the interferon inducers, poly rI.rC and tilorone
164. Lipopolysaccharide evokes the modulation of brain cytochrome P4501A in the rat
165. Cytokines and their receptors in the central nervous system: Physiology, pharmacology and pathology
166. Suppression of hepatic drug metabolism by the interferon inducer
167. 2′,5′-Oligoadenylate-dependent RNase L is a dimer of regulatory and catalytic subunits
168. Physiopathology of detoxification of pentobarbital sodium
169. Expression of cytochrome P450 side-chain cleavage enzyme and 3β-hydroxysteroid dehydrogenase in the rat central nervous system: A study by polymerase chain reaction and in situ hybridization
170. Induction of cytochrome P450 2A6 expression in humans by the carcinogenic parasite infection, Opisthorchiasis viverrini
171. Nitric oxide-independent suppression of P450 2C11 expression by interleukin-1beta and endotoxin in primary rat hepatocytes
172. Endotoxemia in rats is associated with induction of the P4504A subfamily and suppression of several other forms of cytochrome P450
173. Differential inductive and suppressive effects of endotoxin and particulate irritants on hepatic and renal cytochrome P-450 expression
174. Down-regulation of cytochrome P450 mRNAs and proteins in mice lacking a functional NOS2 gene
175. Interleukin-1 (IL-1) depresses cytochrome P450 levels and activities in mice
176. Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism
177. Endotoxin depresses hepatic cytochrome P450-mediated drug metabolism in women
178. Depression of constitutive murine cytochromes P450 by staphylococcal enterotoxin B
179. Different levels of Schistosoma mansoni infection induce changes in drug-metabolizing enzymes
180. Differential alterations in levels of hepatic microsomal cytochrome P450 isozymes following intracerebroventricular injection of bacterial lipopolysaccharide in rats
181. Mechanism of decrease in levels of hepatic P450 isozymes induced by intracerebral endotoxin: Independence from sympathetic nervous and adrenocortical systems
182. Hepatic cytochrome P450 down-regulation during aseptic inflammation in the mouse is interleukin 6 dependent
183. Interferon-mediated depression of cytochrome P-450-dependent drug biotransformation
184. Inhibition of the synthesis of hepatic cytochrome P-450 by the interferon-inducing agent poly rI. rCi
185. Homogeneous interferon from E. coli depresses hepatic cytochrome P-450 and drug biotransformation
186. Adverse drug reactions and debrisoquine/sparteine (P450IID6) polymorphism in patients with fibromyalgia
187. A study of hepatic mitochondrial respiration and microsomal cytochrome P450 content in mice infected with the liver fluke Fasciola hepatica
188. Effects of endotoxin upon rat hepatic microsomal drug metabolism in vivo and in vitro
189. Antipyrine clearance in pneumonia
190. Role of mononuclear phagocytes in decreased hepatic drug metabolism following administration of Corynebacterium parvum
191. Differential effects of recombinant interferon alpha on constitutive and inducible cytochrome P450 isozymes in mouse liver
192. Spatiotemporal induction patterns of cytokine and related immune signal molecule mRNAs in response to intrastriatal injection of lipopolysaccharide
193. Expression of multiple forms of brain cytochrome P450
194. Interferon reduces hepatic drug metabolism in vivo in mice
195. Expression, catalytic activity, and inducibility of cytochrome P450 2E1 (CYP2E1) in the rat central nervous system
196. Induction of cytochrome P450 2E1 expression in rat and gerbil astrocytes by inflammatory factors and ischemic injury
197. The interleukin-2 receptor down-regulates the expression of cytochrome P450 in cultured rat hepatocytes
198. Effect of adjuvant-induced arthritis on hepatic drug metabolism in rats
199. Importance of T-cell-dependent inflammatory reactions in the decline of microsomal cytochrome P450 concentration in the livers of rats infected with Fasciola hepatica
200. Cytochrome P-450 expression in sudden infant death syndrome
201. Ontogenesis of CYP2C-dependent arachidonic acid metabolism in the human liver: Relationship with sudden infant death syndrome
202. Quinine disposition during malaria and during induced fever
203. Effects of Plasmodium berghei infection on cytochromes P-450 2E1 and 3A2
204. Localization and characterization of cytochrome P450 in the brain. In vivo and in vitro investigations on phenytoin- and phenobarbital-inducible isoforms
205. Theophylline toxicity and viral infection
206. Glucocorticoids and immune function: Physiological relevance and pathogenic potential of hormonal dysfunction
207. Inhibition of antipyrine metabolism by interferon
208. Inhibition of theophylline metabolism by interferon
209. Inhibition of cytochromes P450 by nitric oxide and a nitric oxide releasing agent
210. Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced brain injury
211. Brain IL-1beta induces local inflammation but systemic anti-inflammatory response through stimulation of both hypothalamic-pituitary-adrenal axis and sympathetic nervous system
212. Acute intoxication with theophylline while on chronic therapy
213. Transcriptional and post-transcriptional supression of P450IIC11 and P450IIC12 by inflammation
214. Regulation of cytochrome P450IIC12 expression by interleukin-1 alpha, interleukin-6, and dexamethasone