Use of a novel real-time quantitative reverse transcription-polymerase chain reaction method to study the effects of cytokines on cytochrome P450 mRNA expression in mouse liver

Drug Metabolism and Disposition

Volumn 28, Issue 6, 2000, Pages 709-713

  Pan, Jinmei ^a   Xiang, Qian ^a   Ball, Simon ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 3A; CYTOCHROME P450 ISOENZYME; CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; PHENACETIN O DEETHYLASE; TUMOR NECROSIS FACTOR ALPHA;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME INDUCTION; INFLAMMATION; MALE; MESSENGER RNA SYNTHESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; CYTOKINES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIVER; MALE; MICE; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0034091584     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Abdel-Razzak Z, Loyer P, Fautrel A, Gautier JC, Corcos L, Turlin B, Beaune P and Guillouzo A (1993) Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Mol Pharmacol 44:707-715.
2. Barker CW, Fagan JB and Sinclair JF (1992) Interleukin-1 beta suppresses the induction of P4501A1 and 1A2 mRNAs in isolated hepatocytes. J Biol Chem 267:8050-8055.
3. Bassler HA, Flood SJA, Livak KJ, Marmaro J, Knorr R and Batt CA (1995) Use of a fluorogenic probe in a PCR-based assay for the detection of Listeria monocytogenes. Appl Environ Microbiol 61:3724-3728.
4. Cantoni L, Carelli M, Ghezzi P, Delgado R, Faffioni R and Rizzardini M (1995) Mechanisms of interleukin-2-induced depression of hepatic cytochrome P-450 in mice. Eur J Pharmacol 292:257-263.
5. Chen JQ, Strom A, Gustafsson JA and Morgan ET (1995) Suppression of the constitutive expression of cytochrome P450 2C11 by cytokines and interferons in primary cultures of rat hepatocytes: Comparison with induction of acute-phase genes and demonstration that CYP2C11 promoter sequences are involved in the suppressive response to interleukins 1 and 6. Mol Pharmacol 47:940-947.
6. Chen YL, Florentin I, Batt AM, Ferrari L, Giroud JP and Chauvelot-Moachon L (1992) Effect of interleukin-6 on cytochrome P450-dependent mixed-function oxidases in the rat. Biochem Pharmacol 44:137-148.
7. Clark MA, Bing BA, Gottschall PE and Williams JF (1995) Differential effect of cytokines on the phenobarbital or 3-methylcholanthrene induction of P450 mediated monooxygenase activity in cultured rat hepatocytes. Biochem Pharmacol 6:97-104.
8. Corcos L (1992) PB and dexamethasone induce expression of cytochrome P-450 genes from subfamilies IIB, IIC, and IIIA in mouse liver. Drug Metab Dispos 20:797-801.
9. Damon M, Fautrel A, Guillouzo A and Corcos L (1996) Genetic analysis of the PB regulation of the cytochrome P450 2b9 and aldehyde dehydrogenase type 2 mRNAs in mouse liver. Biochem J 317:481-486.
10. Fukuda Y and Sassa S (1994) Suppression of cytochrome P4501A1 by interleukin-6 in human hepG2 hepatoma cells. Biochem Pharmacol 47:1187-1195.
11. Ghezzi P, Saccardo B, Villa P, Rossi V, Blanchi M and Dinarello CA (1986) Role of interleukin-1 in the depression of liver drug metabolism by endotoxin. Infect Immunol 54:837-840.
12. Gibson UEM, Heid CA and Williams PM (1996) A novel method for real-time quantitative RT-PCR. Genome Res 6:995-1001.
13. Guillen MI, Donato MT, Jover R, Castell JV, Fabra R, Trullenque R and Gomez-Lechon MJ (1998) Oncostatin M down-regulates basal and induced cytochromes P450 in human hepatocytes. J Pharmacol Exp Ther 285:127-134.
14. Heid CA, Stevens J, Livak KJ and Williams PM (1996) Real-time quantitative PCR. Genome Res 6:986-994.
15. Kiyohara C, Mohri N, Hirohata T, Haraguchi K, Masuda Y and Nagayama J (1990) Aryl hydrocarbon hydroxylase activity levels in the hepatic microsomal fraction from MC- or TCDD-treated mice: A comparison between aromatic hydrocarbon responsive and non-responsive strains. Toxicol Lett 52:73-80.
16. Lee LG, Connell CR and Bloch W (1993) Allelic discrimination by nick-translation PCR with fluorogenic probes. Nucleic Acids Res 2:3761-3766.
17. Livak KJ, Flood SJA, Marmaro J, Giusti W and Deetz K (1995) Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization. PCR Methods Appl 4:357-362.
18. Monshouwer M, Witkamp RF, Nujmeijer SM, Van Amsterdam JG and Van Miert AS (1996) Suppression of cytochrome P45U- and UDP glucuronosyl transferase-dependent enzyme activities by proinflammatory cytokines and possible role of nitric oxide in primary cultures of pig hepatocytes. Toxicol Appl Pharmacol 137:237-244.
19. Morgan ET and Norman CA (1990) Pretranslational suppression of cytochrome P450h (IIC11) gene expression in rat liver after administration of interferon inducers. Drug Metab Dispos 18:649-653.
20. Morgan ET, Thomas KB, Swanson R, Vales T, Hwang J and Wright K (1994) Selective suppression of cytochrome P450 gene expression by interleukins 1 and 6 in rat liver. Biochim Biophys Acta 1219:475-483.
21. Nadin L, Butler AM, Farrell GC and Murray M (1995) Pretranslational down-regulation of cytochromes P450 2C11 and 3A2 in male rat liver by tumor necrosis factor alpha. Gastroenterology 109:198-205
22. Paton TE and Renton KW (1998) Cytokine-mediated down-regulation of CYP1A1 in Hepa1 cells. Biochem Pharmacol 55:1791-1796.
23. Renton KW and Knickle LC (1990) Regulation of hepatic cytochrome P-450 during infectious disease (Review). Can J Physiol Pharmacol 68:777-781.
24. Sakuma T, Ohtake M, Katsurayama Y, Jarukamjorn K and Nemoto N (1999) Induction of CYP1A2 by PB in the livers of aryl hydrocarbon-responsive and -nonresponsive mice. Drug Metab Dispos 27:379-384.
25. Shedlofsky SI, Israel BC, McClain CJ, Hill DB and Blouin RA (1994) Endotoxin administration to humans inhibits cytochrome P450-mediated drug metabolism. J Clin Invest 94:2209-2214.
26. Trautwein C, Ramadori G, Gerken G, Meyer zum Bödschenfelde K-H and Manns M (1992) Regulation of cytochrome P450 IID by acute phase mediators in C3H/HeJ mice. Biochem Biophys Res Commun 182:617-623.
27. Warren GW, Plolyac SM, Gary DS, Mattson MP and Blouin RA (1999) Hepatic cytochrome P450 expression in tumor necrosis factor-α receptor (p55/p75) knockout mice after endotoxin administration, J Pharmacol Exp Ther 288:945-950.