Nitric oxide-mediated inhibition of cytochrome P450 by interferon-γ in human hepatocytes

Journal of Pharmacology and Experimental Therapeutics

Volumn 281, Issue 1, 1997, Pages 484-490

  Donato, M Teresa ^a   Guillén, M Isabel ^a   Jover, Ramiro ^a   Castell, José V ^a   Gómez Lechón, M José ^a  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

COUMARIN DERIVATIVE; CYTOCHROME P450; ETHOXYRESORUFIN; GAMMA INTERFERON; N ACETYL S NITROSOPENICILLAMINE; N(G) METHYLARGININE; NITRIC OXIDE; RECOMBINANT GAMMA INTERFERON; RESORUFIN DERIVATIVE; TESTOSTERONE;

ADULT; AGED; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEALKYLATION; DRUG HYDROXYLATION; DRUG TRANSFORMATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; INHIBITION KINETICS; LIVER CELL CULTURE; LIVER MICROSOME METABOLISM; MALE; PRIORITY JOURNAL;

ADULT; AGED; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HUMANS; INTERFERON TYPE II; LIVER; MALE; MIDDLE AGED; NITRIC OXIDE; OMEGA-N-METHYLARGININE; RNA, MESSENGER;

EID: 0031007899     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. ABDEL-RAZZAK, Z., LOYER, P., FAUTREL, A., GAUTIER, J. C., CORCOS, L., TURLIN, B., BEAUNE, P. AND GUILLOUZO, A.: Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Mol. Pharmacol. 44: 707-715, 1993.
2. ABDEL-RAZZAK, Z., CORCOS, L., FAUTREL, A., CAMPION, J. P. AND GUILLOUZO, A.: Transforming growth factor-β1 down-regulates basal and polycyclic aromatic hydrocarbon-induced cytochromes P-450 1A1 and 1A2 in adult human hepatocytes in primary culture. Mol. Pharmacol. 46: 1100-1110, 1994.
3. BILLIAR, T. R., CURRAN, R. D., STUEHR, D. J., WEST, M. A., BENTZ, B. G. AND SIMMONS, R. L.: An L-arginine-dependent mechanism mediates Kupffer cell inhibition of hepatocyte protein synthesis in vitro. J. Exp, Med. 169: 1467-1472, 1989.
4. BILLIAR, T. R., CURRAN, R. D., STUEHR, D. J., STADLER, J., SIMMONS, R. L. AND MURRAY, S. A.: Inducible cytosolic enzyme activity for the production of nitrogen oxides form L-arginine in hepatocytes. Biochem. Biophys. Res. Commun. 168: 1034-1040, 1990.
5. BROCKMEYER, N. H., MARTINS. L., SPATZ, D., TILLMANN, I. AND GOSS, M.: Endogenous Interferon plasma levels and antipyrine pharmacokinetics in patients with viral infections. Int. J. Clin. Pharmacol. Ther. Toxicol. 30: 530-533, 1992.
6. BURKE, M. D., THOMPSON, S., ELCOMBE, C. R., HALPERT, J., HAAPARANTA, T. AND MAYER, R. T.: Ethoxy-, pentoxy-, and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochromes P-450. Biochem. Pharmacol. 34: 3337-3345, 1985.
7. CARLSON, T. J. AND BILLINGS, R. E.: Role of nitric oxide in the cytokine-mediated regulation of cytochrome P-450. Mol. Pharmacol. 49: 796-001, 1996.
8. CHEN, J. Q., STROM, A., GUSTAFSSON, J. A. AND MORGAN, E. T.: Suppression of the constitutive expression of cytochrome P-450 2C11 by cytokines and interferons in primary cultures of rat hepatocytes: Comparison with induction of acute-phase genes and demonstration that CYP2C11 promoter sequences are involved in the suppressive response to interleukins 1 and 6. Mol. Pharmacol. 47: 940-947, 1995.
9. CHAMULITRAT, W., JORDAN, S. J., MASON, R. P., LITTON. A. L., WILSON, J. G., WOOD E. R., WOLBERG, G. AND MOLINA, L.: Targets of nitric oxide in a mouse model of liver inflammation by Corynebacterium parvum. Arch. Biochem. Biophys. 316: 30-37, 1995.
10. CHOMCZYNSKI, P. AND SACCHI, N.: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
11. CRAIG;, P. I., MEHTA, I., MURRAY, M., MCDONALD, D., ASTROM, A., VAN DER MEIDE, P. H. AND FARRELL, G. C.: Interferon down regulates the male-specific cytochrome P450IIIA2 in rat liver. Mol. Pharmacol. 38: 313-318, 1990.
12. CRAIG, P. I., MURRAY, M. AND FARRELL, G. C.: Interferon suppresses the isoform-specific activities of hepatic cytochrome P450 in female rats. Biochem. Pharmacol. 43: 908-910, 1992.
13. CRAIG, P. I., TAPNER, M. AND FARRELL, G. C.: Interferon suppresses erythromycin metabolism in rats and human subjects. Hepatology 17: 230-235, 1993.
14. CRIBB, A. E., DELAPORTE, E., KIM, S. G., NOVAK, R. F. AND RENTON, K. W.: Regulation of cytochrome P-4501A and cytochrome P-4502E induction in the rat during the production of Interferon α/β. J. Pharmacol. Exp. Ther. 268: 487-494, 1994.
15. DONATO, M. T., HERRERO, E., GÓMEZ-LECHÓN, M. J. AND CASTELL, J. V.: Inhibition of monooxygenase activities in human hepatocytes by interferons. Toxic. In Vitro 7: 481-485, 1993a.
16. DONATO, M. T., GÓMEZ-LECHÓN, M. J. AND CASTELL, J. V.: A microassay for measuring cytochrome P450IA1 and P450IIB1 activities in intact human and rat hepatocytes cultured on 96-well plates. Anal. Biochem. 213: 29-33, 1993b.
17. GELLER, D. A., NUSSLER, A. K., DI SILVIO, M., LOWENSTEIN, C. L., SHAPIRO, R. A., WANG, S. C., SIMMONS R. L. AND BILLIAR, T. R.: Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc. Natl. Acad. Sci. U.S.A. 90: 522-526, 1993.
18. GHEZZI, P., BIANCHI, M., GIANERA, L., LANDOLFO, S. AND SALMONA, M.: Role of reactive oxygen intermediates in the interferon-mediated depression of hepatic drug metabolism and protective effect of N-acetylcysteine. Cancer Res. 45: 3444-3447, 1985.
19. GÓMEZ-LECHÓN, M. J., LÓPEZ, P., DONATO, T., MONTOYA, A., LARRAURI, A., GIMÉNEZ, P., TRULLENQUE, R., FABRA, R. AND CASTELL, J. V.: Culture of human hepatocytes from small surgical biopsies. Biochemical characterization and comparison with in vivo. In Vitro Cell. Dev. Biol. 26: 67-74, 1990.
20. GONZALEZ, F. J.: Molecular genetics of the P-450 superfamily. Pharmacol. Ther. 45: 1-38, 1990.
21. GONZALEZ, F. J., SCHMID, B. J., UMENO, M., MCBRIDE, O. W., HARDWICK, J. P., MEYER, U. A., GELBOIN, H. V. AND IDLE, J. R.: Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase. DNA 7: 79-86, 1988.
22. HODGSON, P. D. AND RENTON, K. W.: The role of nitric oxide generation in interferon-evoked cytochrome P450 down-regulation. Int. J. Immunopharmacol. 17: 995-1000, 1995.
23. IGNARRO, L. J.: Biosynthesis and metabolism of endothelium-derived nitric oxide. Annu. Rev. Pharmacol. Toxicol. 30: 535-560, 1990.
24. ISRAEL, B. C., BLOUIN, R. A., MCINTYRE, W. AND SHEDLOFSKY, S. I.: Effects of interferon-α monotherapy on hepatic drug metabolism in cancer patients. Br. J. Clin Pharmac. 36: 229-235, 1993.
25. KHATSENKO, O. G., GROSS, S. S., RIFKIND, A. B. AND VANE, J. R.: Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants. Proc. Natl. Acad. Sci. U.S.A. 90: 11147-11151, 1993.
26. LOWRY, O. H., ROSEBROUGH, N. J., FARR, A. L. AND RANDALL, R.: Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275, 1951.
27. MANNERING G. J., DELORIA L. B. AND ABBOT, V.: Role of xanthine oxidase in the interferon-mediated depression of the hepatic cytochrome P-450 system in mice. Cancer Res. 48: 2107-2112, 1988.
28. MONCADA, S., PALMER, R. M. J. AND HIGGS, E. A.: Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43: 109-142, 1991.
29. MORGAN, E. T. AND NORMAN, C. A.: Pretranslational suppression of cytochrome P-450h (IIC1) gene expression in rat liver after administration of interferon inducers. Drug Metab. Dispos. 18: 649-653, 1990.
30. MUNTANÉ-RELAT, J., OURLIN, J. C., DOMERGUE, J. AND MAUREL, P.: Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture. Hepatology 22: 1143-1153, 1995.
31. NUSSLER, A. K., DI SILVIO, M., BILLIAR, T. R., HOFFMAN, R. A., GELLER, D. A., SELBY, R., MADARIAGA, J. AND SIMMONS, R. L.: Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin. J. Exp. Med. 176: 261-264, 1992.
32. NUSSLER, A. K., ZHI-ZE, L., DI SILVIO, M., SWEETLAND, M. A., GELLER, D. A., LANCASTER, J. R., BILLIAR, T. R., FREESWICK, P. D., LOWENSTEIN, C. L. AND SIMMONS R. L.: Hepatocyte inducible nitric oxide synthesis is influenced in vitro by cell density. Am. J. Physiol. 266 (Cell Physiol. 31): C394-C401, 1994.
33. OKUNO, H., KITADA, Y., TAKASU, M., KANO, H., KUMEIDA, K., SEKI, T., SHIOZAKI, Y. AND SAMESHIMA, Y.: Depression of drug metabolizing activity in human liver by interferon-α. Eur. J. Clin. Pharmacol 39: 365-367, 1990.
34. OKUNO, H., TAKASU, M., KANO, H., SEKI, T., SHIOZAKI, Y. AND INOUE, K: Depression of drug-metabolizing activity in the human liver by interferon-β. Hepatology 17: 65-69, 1993.
35. PONTE, P., NG, S. Y., ENGEL, J., GUNNING, P. AND KEDES, L.: Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA. Nucleic Acid Res. 12: 1687-1696, 1984.
36. RENTON, K. W. AND KNICKLE, L. C.: Regulation of hepatic cytochrome P-450 during infectious disease. Can. J. Physiol Pharmacol. 68: 777-781, 1990.
37. SAKAI, H., OKAMOTO, T. AND KIKKAWA, Y.: Suppression of hepatic drug metabolism by the interferon inducer, polyriboinosinic acid: Polyribocitidylic acid. J. Pharmacol. Exp. Ther. 263: 381-386, 1992.
38. STADLER, J., TROCKFELD, J., SCHMALIX, W. A., BRILL, T., SIEWERT, J. R., GREIM, H. AND DOEHMER, J.: Inhibition of cytochromes P450IA by nitric oxide. Proc. Natl. Acad. Sci. U.S.A. 91: 3559-3563, 1994.
39. STAR, R. A.: Nitric oxide. Am. J. Med. Sci. 306: 348-358, 1993.
40. STEIN, C. S. AND STREJAN, G. H.: Rat splenocytes inhibit antigen-specific lymphocyte proliferation through a reactive nitrogen intermediate (RNI)-dependent mechanism and exhibit increased RNI production in response to IFN. Cell. Immunol. 150: 281-297, 1993.
41. WAXMAN, D. J., LAPENSON, D. P., AOYAMA, T., GELBOIN, H. V., GONZALEZ, F. J. AND KORZEKWA, K.: Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s. Arch. Biochem. Biosphys. 290: 160-166, 1991.
42. WILLIAMS, S. J., BAIRD-LAMBERT, J. A. AND FARRELL, G. C.: Inhibition of theophylline metabolism by interferon. Lancet 2: 939-941, 1987.
43. WILLIAMS, S. J. AND FARRELL, G. C.: Inhibition of antipyrine metabolism by interferon. Br. J. Clin. Pharmacol. 22: 610-612, 1986.
44. WINK, D. A., OSAWA, Y., DARBYSHIRE, J. F., JONES, C. R., ESHENAUR, S. C. AND NIMS, R. W.: Inhibition of cytochromes P450 by nitric oxide and a nitric oxide-releasing agent. Arch. Biochem. Biophys. 300: 115-123, 1993.
45. YUN, C. H., SHIMADA, T. AND GUENGERICH, F. P.: Purification and characterization of human liver microsomal cytochrome P-450 2A6. Mol. Pharmacol. 40: 679-685, 1991.