Down-regulation of the hepatic cytochrome P450 by an acute inflammatory reaction: Implication of mediators in human and animal serum and in the liver

British Journal of Pharmacology

Volumn 121, Issue 6, 1997, Pages 1164-1170

  El Kadi, Ayman O S ^a   Maurice, Hélène ^a   Ong, Huy ^a   Du Souich, Patrick ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Cytochrome P450; Human serum mediators; Inflammation; Rabbit serum mediators; Turpentine; Viral infection

Indexed keywords

1 METHYLURIC ACID; 1,3 DIMETHYLURIC ACID; 3 METHYLXANTHINE; CYTOCHROME P450; LIVER ENZYME; TURPENTINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME REGULATION; HUMAN; INFLAMMATION; LIPID PEROXIDATION; LIVER; LIVER CELL; MALE; MEDIATOR; NONHUMAN; PRIORITY JOURNAL; UPPER RESPIRATORY TRACT INFECTION; VIRUS INFECTION;

ANIMALS; BIOTRANSFORMATION; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DOWN-REGULATION; HUMANS; INFLAMMATION MEDIATORS; LIPID PEROXIDATION; LIVER; MALE; RABBITS; THEOPHYLLINE; VIRUS DISEASES;

EID: 0030845424     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701232     Document Type: Article

References (39)

1. AKAHOSHI, T., OPPENHEIM, J.J. & MATSUSHIMA, K. (1988). Interleukin 1 stimulates its own receptor expression on human fibroblasts through the endogenous production of prostaglandin(s). J. Clin. Invest., 82, 1219-1224.
2. ASHTON, F.W., JAMIESON, J.C. & FRIESEN, A.D. (1970). Studies on the effect of inflammation on rat serum proteins. Can. J. Biochem., 48, 841-850.
3. BARAKAT, M. & DU SOUICH, P. (1996). Effect of nifedipine on the elimination of theophylline in the rabbit subjected to hypoxia or to an inflammatory reaction. J. Pharm. Pharmacol., 48, 906-910.
4. BECK, F.J. & WHITEHOUSE, M.W. (1974). Impaired drug metabolism in rats associated with acute inflammation: a possible assay for anti-injury agents. Proc. Soc. Exp. Biol. Med., 145, 135-140.
5. BELPAIRE, F.M., DE SMET, F., CHINDAVIJAK, B., FRAEYMAN, N. & BOGAERT, M.G. (1989). Effect of turpentine-induced inflammation on the disposition kinetics of propranolol, metoprolol and antipyrine in the rat. Fundam. Clin. Pharmacol., 3, 79-88.
6. CHANG, K.C., LAUER, B.A. & BELL, T.D. (1978). Altered theophylline pharmacokinetics during an acute respiratory viral illness. Lancet, 1, 1132-1133.
7. DELORIA, L., ABBOT, V., GOODERHAM, N. & MANNERING, G.J. (1985). Induction of xanthine oxidase and depression of cytochrome P-450 by interferon inducers: genetic difference in the response of mice. Biochem. Biophys. Res. Commun., 131, 109-114.
8. DINARELLO, C.A. (1994). The interleukin-1 family: 10 years of discovery. FASEB J., 8, 1314-1325.
9. DU SOUICH, P., HOEN, B., SAUNIER, C., HARTEMANN, D., SAUTEGEAU, A., CORNETTE, A., DELORME, N., POLU, J.M. & SADOUL, P. (1989). Blood gas disturbances and theophylline disposition in patients with COLD with and without hypoxemia. Chest, 95, 1028-1032.
10. GEISTERFER, M., RICHARDS, C., BAUMANN, M., FEY, G., GWYNNE, D. & GAULDIE, J. (1993). Regulation of IL-6 and the hepatic IL-6 receptor in acute inflammation in vivo. Cytokine, 5, 1-7.
11. GHEZZI, P., BIANCHI, M., GIANERA, L., LANDOLFO, S. & SALMONA, M. (1985). Role of reactive oxygen intermediates in the interferon-mediated depression of hepatic drug metabolism and protective effect of N-acetylcysteine in mice. Cancer Res., 45, 3444-3447.
12. GHEZZI, P., SACCARDO, B., VILLA, P., ROSSI, V., BIANCHI, M. & DINARELLO, C.A. (1986). Role of interleukin-1 in the depression of liver drug metabolism by endotoxin. Infect. Immun., 54, 837-840.
13. GRAY, J.D., RENTON, K.W. & HUNG, O.R. (1983). Depression of theophylline elimination following BCG vaccination. Br. J. Clin. Pharmacol., 16, 735-737.
14. HA, H.R., CHEN, J., FREIBURGHAUS, A.U. & FOLLATH, F. (1995). Metabolism of theophylline by cDNA-expressed human cytochrome P-450. Br. J. Clin. Pharmacol., 39, 321-326.
15. ISHIKAWA, M., SASAKI, K., OZAKI, M., WATANABE, K., TAKAYANAGI, Y. & SOSAKI, K. (1991). Hepatic drug metabolizing activity in rats with carrageenin-induced inflammation. J. Pharmacobio. Dyn., 14, 132-138.
16. KOBUSCH, A.B., ERILL, S. & DU SOUICH, P. (1986). Relationship between changes in seromucoid concentrations and the rate of oxidation or acetylation of several substrates. Drug Metab. Dispos., 14, 663-667.
17. KOCH, K.C., YE, K., CLARK, B.D. & DINARELLO, C.A. (1992). Interleukin 4 (IL) 4 up-regulates gene and surface IL 1 receptor type I in murine T helper type 2 cells. Eur. J. Immunol., 22, 153-157.
18. KOIZUMI, A., WALFORD, R.L. & IMAMURA, T. (1986). Treatment with poly I.C. enhances lipid peroxidation and the activity of xanthine oxidase, and decreases hepatic P-450 content and activities in mice and rats. Biochem. Biophys. Res. Commun., 134, 632-637.
19. MAHU, J.L. & FELDMANN, G. (1984). Study of biochemical behaviour of some exported and nonexported hepatic proteins during an acute inflammatory reaction in the rat. Enzyme, 31, 234-240.
20. MOOCHHALA, S. & RENTON, K.W. (1991). The effect of INF-alpha-Con1 on hepatic cytochrome P-450 and protein synthesis and degradation in hepatic microsomes. Int. J. Immunopharmacol., 13, 903-912.
21. MORGAN, E.T. (1989). Suppression of constitutive cytochrome P-450 gene expression in livers of rats undergoing an acute phase response to endotoxin. Mol. Pharmacol., 36, 699-707.
22. MUNTANÉ-RELAT, J., OURLIN, J.C., DOMERGUE, J. & MAUREL, P. (1995). Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture. Hepatology, 22, 1143-1153.
23. LOWRY, O.H., ROSEBROUGH, N.J., FARR, A.L. & RANDALL, R.J. (1951). Protein measurement with the folin phenol reagent. J. Biol. Chem., 193, 265-275.
24. OHKAWA, H., OHISHI, N. & YAGI, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95, 351-358.
25. OMURA, T. & SATO, R. (1964). The carbon monoxide-binding pigment of liver microsomes. 1. Evidence for its hemoprotein nature. J. Biol. Chem., 239, 2370-2378.
26. PARENT, C., BELANGER, P.M., JUTRAS, L. & DU SOUICH, P. (1992). Effect of inflammation on the rabbit hepatic cytochrome P-450 isoenzymes. Alterations in the kinetics and dynamics of tolbutamide. J. Pharmacol. Exp. Ther., 261, 780-787.
27. PROULX, M. & DU SOUICH, P. (1995). Inflammation-induced decrease in cytochrome P450 in conscious rabbits is accompanied by an increase in hepatic oxidative stress. Res. Commun. Mol. Path. Pharmacol., 87, 221-236.
28. PROULX, M., MAUPOIL, V., ROCHETTE, L. & DU SOUICH, P. (1995). Increase in antilipoperoxidant activity of plasma as a consequence of an inflammatory reaction induced by subcutaneous turpentine in the rabbit. Free Rad. Res., 23, 245-254.
29. RENTON, K.W. (1986). Factors affecting drug biotransformation. Clin. Biochem., 19, 2221-2230.
30. RENTON, K.W., GRAY, J.D. & HALL, R.I. (1981). Decreased elimination of theophylline after influenza vaccination. Can. Med. Assoc. J., 123, 288-290.
31. ROBSON, R.A., MATTHEWS, A.P., MINERS, J.O., MCMANUS, M.E., MEYER, U.A., HALL, P.M. & BIRKETT, D.J. (1987). Characterization of theophylline metabolism in human liver microsomes. Br. J. Clin. Pharmacol., 24, 293-330.
32. SARKAR, M.A. & JACKSON, B.J. (1994). Theophylline demethylations as probes for P4501A1 and P4501A2. Drug Metab. Dispos., 22, 827-834.
33. SEGLEN, P.O. (1976). Preparation of isolated rat liver cells. Methods Cell Biol., 13, 29-83.
34. SHIRAKI, H. & GUENGERICH, F.P. (1984). Turnover of membrane proteins: kinetics of induction and degradation of seven forms of rat liver microsomal P-450, NADPH-cytochrome P-450 reductase, and epoxide hydrolase. Arch. Biochem. Biophys., 235, 86-96.
35. SONNE, J., DOSSING, M., LOFT, S. & ANDREASEN, P.B. (1985). Antipyrine clearance in pneumonia. Clin. Pharmacol. Ther., 37, 701-704.
36. VOZEH, S., POWELL, J.R., RIEGELMAN, S., COSTELLO, J.F., SCHEINER, L.B. & HOPEWELL, P. (1978). Changes in theophylline clearance during acute illness. J. Am. Med. Assoc., 240, 1882-1884.
37. WILLIAMS, J.F., BEMENT, W.J., SINCLAIR, J.F. & SINCLAIR, P.R. (1991). Effect of interleukin 6 on phenobarbital induction of cytochrome P-450IIB in cultured rat hepatocytes. Bioch. Biophys. Res. Commun., 178, 1049-1055.
38. YE, K., KOCH, K.C., CLARK, B.D. & DINARELLO, C.A. (1992). Interleukin-1 down regulates gene and surface expression of interleukin-1 receptor type I by destabilizing its mRNA whereas interleukin-2 increases its expression. Immunology, 75, 427-434.
39. ZHANG, Z.Y. & KAMINSKY, L.S. (1995). Characterization of human cytochrome P450 involved in theophylline 8-hydroxylation. Biochem. Pharmacol., 50, 205-211.