Differential alterations in levels of hepatic microsomal cytochrome P450 isozymes following intracerebroventricular injection of bacterial lipopolysaccharide in rats

Archives of Toxicology

Volumn 72, Issue 8, 1998, Pages 492-498

  Shimamoto, Yoshinori ^a   Kitamura, Hiroshi ^a   Hoshi, Hidenobu ^a   Kazusaka, Akio ^a   Funae, Yoshihiko ^b   Imaoka, Susumu ^b   Saito, Masayuki ^a   Fujita, Shoichi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cytochrome P450; Drug metabolism; Intracerebroventricular; Lipopolysaccharide; Meningitis

Indexed keywords

7 ETHOXYCOUMARIN DEETHYLASE; BACTERIUM LIPOPOLYSACCHARIDE; CYTOCHROME P450 ISOENZYME; ETHOXYRESORUFIN DEETHYLASE; N DEMETHYLASE; OXYGENASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENDOTOXINS; ESCHERICHIA COLI; IMMUNOBLOTTING; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENTRICULAR; ISOENZYMES; LIPOPOLYSACCHARIDES; MALE; MICROSOMES, LIVER; RATS; RATS, WISTAR;

ANIMALIA; BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS PHAGE 3A;

EID: 0031876486     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050533     Document Type: Article

References (56)

1. Arlotto MP, Sonderfan AJ, Klaassen CD, Parkinson A (1987) Studies on pregnenolone-16α-carbonitrile inducible form of rat liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase. Biochem Pharmacol 36: 3859-3866
2. Beam TR Jr, Allen JC (1977) Blood, brain, and cerebrospinal fluid concentrations of several antibiotics in rabbits with intact and inflamed meninges. Antimicrob Agents Chemother 12: 710-716
3. Bertini R, Bianchi M, Erroi A, Villa P, Ghezzi P (1989) Dexamethasone modulation of in vivo effects of endotoxin, tumor necrosis factor, and interleukin-1 on liver cytochrome P-450, plasma fibrinogen, and serum ion. J Leukocyte Biol 46: 254-262
4. Boucher BA, Kuhl DA, Fabian TC.,Robertson JT (1991) Effect of neurotrauma on hepatic drug clearance. Clin Pharmacol Ther 50: 487-497
5. Brandtzaeg P, Ovsteboo R, Kierulf P (1992) Compartmentalization of lipopolysaccharide production correlates with clinical presentation in meningococcal disease. J Infect Dis 166: 650-652
6. Chang T, Levine M, Bandiera SM, Bellward GD (1992) Selective inhibition of rat hepatic microsomal cytochrome P-450. I. Effect of the in vivo administration of cimetidine. J Pharmacol Exp Ther 260: 1441-1449
7. Chen YL, Florentin I, Batt AM, Ferrari L, Giroud JP, Chauvelot-Moachon L (1992) Effects of interleukin-6 on cytochrome P-450 dependent mixed-function oxidases in the rat. Biochem Pharmacol 44: 137-148
8. Chiba M, Nishihara E, Fujita S, Suzuki T (1985) Position selective sex difference in imipramine metabolism in rat liver microsomes. Biochem Pharmacol 34: 898-900
9. Chin T, Fong IW, Vandenbroucke A (1990) Pharmacokinetics of fluconazole in serum and eerebrospinal fluid in a patient with AIDS and cryptoeoccal meningitis. Pharmacotherapy 10: 305-307
10. Coto JA, Williams JF (1989) Effect of endotoxin to differentially affect cytochrome P-450 monooxygenase activities of untreated rats and animals induced with phenobarbital or 3-methylcholanthrene. Int J Immunopharmacol 11: 623-628
11. Craig PI, Mehta I, Murray M, McDonald D, Astrom A, van der Meide PH, Farrell GC (1990) Interferon down regulates the male-specific cytochrome P450IIIA2 in rat liver. Mol Pharmacol 38: 313-318
12. 2 into the central nervous system from blood. Br J Pharmacol 66: 565-572
13. De Simoni MG, Sironi M, Luigui AD, Manfridi A, Mantovani A, Ghezzi P (1990) Intracerebroventricular injection of interleukin 1 induces high circulating levels of interleukin 6. Am J Physiol 171: 1773-1778
14. Diamond RD, Bennett JE (1974) Prognostic factors in cryptoccal mengitis. Ann Intern Med 80: 176-181
15. Dismukes WE, Cloud G, Gallis HA, Kerkering TM, Medoff G, Craven PC, Kaplowitz LG, Fisher JF, Gregg CR, Bowles CA, Shadomy S, Stamm AM, Diasio RB, Kaufman L, Soong S-J, Blackwelder WC (1987) Treatment of cryptococcal meningitis with combination amphotericin B and flucytosine for four as compared with six weeks. N Engl J Med 317: 334-341
16. Ducker TB, Simmons RL (1968) The pathogenesis of meningitis: systemic effects of meningococcal endotoxin within the cerebrospinal fluid. Arch Neurol 18: 123-128
17. Ervine CM, Matthew DE, Brennan B, Houston JB (1996) Comparison of ketoconazole and fluconazole as cytochrome P450 inhibitors. Use of steady-state infusion approach to achieve plasma concentration-response relationships. Drue Metab Dispos 24: 211-215
18. Ferrari L, Herber R, Batt AM, Siest G (1993) Differential effects of human recombinant interleukin-1b and dexamethasone on hepatic drug-metabolizing enzymes in male and female rats. Biochem Pharmacol 45: 2269-2277
19. Funae Y, Imaoka S (1985) Simultaneous purification of multiple forms of rat liver microsomal cytochrome P-450 by high-performance liquid chromatography. Biochim Biophys Acta 842: 119-312
20. Funae Y, Imaoka S (1987) Purification and characterization of liver microsomal cytochrome P-450 from untreated male rats. Biochim Biophys Acta 926: 349-358
21. Gottschall PE, Konami G, Arimura A (1992) Increased circulating interleukin-1 and interleukin-6 after intracerebroventricular injection of lipopolysaccharide. Neuroendocrinology 56: 935-938
22. Greenlee WF, Poland A (1978) An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL 6J and DBA 2J mice by phenobarbital. 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Pharmacol Exp Ther 205: 596-605
23. Guengerich FP, Dannan GA, Wright ST, Martin VV, Kaminsky LS (1982) Purification and characterization of liver microsomal cytochrome P450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta;-naphthoflavone. Biochemistry 21: 6019-6030
24. Hallenbeck JM, Dutka AJ, Vogel SN, Heldman E, Doron DA, Feuerstein G (1991) Lipopolysaccharide-induction of tumor necrosis factor activity in rats with and without risk factors for stroke. Brain Res 541: 115-120
25. Humpherey MJ, Jevons S, Tarbit MH (1985) Pharmacokinetic evaluation of UK-49.858, a metabolically stable triazole antifungal drug, in animals and humans. Antimicrob Agents Chemother 28: 648-653
26. Kitamura H, Shimamoto Y, Morimatsu M, Terao A, Saito M (1995) Plasma haptoglobin response to intracerebroventricular administration of cytokines in rats. Biomed Res 16: 353-356
27. Kokwaro GO, Glazier AP, Ward SA, Breckenridge AM, Edwards G (1993) Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes. Biochem Pharmacol 45: 1235-1241
28. Kurokohchi K, Yoneyama H, Matsuo Y, Nishioka M, Ichikawa Y (1992) Effects of interleukin 1α in the activities and gene expressions of the cytochrome P450IID subfamily. Biochem Pharmacol 44: 1669-1674
29. 4. Nature 227: 680-685
30. Lee SC, Liu W, Dickson DW, Brosnan CF, Berman JW (1993) Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta. J Immunol 150: 2659-2667
31. Lennard P (1990) Image analysis for all. Nature 347: 103-104
32. Long NC, Otterness I, Kunkel SL, Vander AJ, Kluger MJ (1990) Roles of interleukin-1β and tumor necrosis factor in lipopolysaccharide fever in rats. Am J Physiol 259: R724-R728
33. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin Phenol reagent. J Biol Chem 193: 265-275
34. Mashburn TA Jr, Llanos J, Ahokas RA, Blatteis CM (1986) Thermal and acute-phase protein responses of guinea pigs to intrapreoptic injections of leukotrienes. Brain Res 376: 285-291
35. McKindley DS, Boucher BA, Hess MM, Rodman JH, Feler C, Fabian TC (1997) Effect of acute response on phenytoin metabolism in neurotrauma patients. J Clin Pharmacol 37: 129-139
36. Morgan ET (1989) Suppression of constitutive cytochrome P-450 gene expression in livers of ruts undergoing an acute phase response to endotoxin. Mol Pharmacol 36: 699-707
37. Morgan ET (1993) Down-regulation of multiple cytochrome P450 gene products by inflammatory mediators in vivo: independence from the hypothalamo-pituitary axis. Biochem Pharmacol 45: 415-419
38. Morgan ET, Thomas KB, Swanson R, Vales T, Hwang J, Wright K (1994) Selective suppression of cytochrome P-450 gene expression by interleukins 1 and 6 in rat liver. Biochim Biophys Acta 1219: 475-483
39. Morimoto A, Nakamori T, Watanabe T, Ono T, Murakami N (1988) Pattern differences in experimental fevers induced by endotoxin, endogenous pyrogen, and prostaglandins. Am J Physiol 254: R633-640
40. Nadin E, Butler AM, Farrell GC, Murray M (1995) Pretranslational down-regulation of cytochrome P450 2C11 and 3A2 in male rat liver by tumor necrosis factor α. Gastroenterology 109: 198-205
41. Omura T, Sato R (1964) The carbon monoxide binding pigment of liver microsomes. J Biol Chem 239: 2370-2378
42. Porter TD, Coon MJ (1991) Cytochrome P-450: multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms. J Biol Chem 266: 13469-13472
43. Quagliarello V, Scheid WM (1992) Bacterial meningitis: pathogenesis, pathophysiology, and progress. N Engl J Med 327: 864-872
44. Salaki JS, Louria DB, Chmel H (1984) Fungal and yeast infections of the central nervous system. Medicine 63: 108-132
45. Sanna PP, Weiss F, Samson ME, Bloom FE, Pich EM (1995) Rapid induction of tumor necrosis factor alpha in the cerebrospinal fluid after intracerebroventricular injection of lipopolysaccharide revealed by a sensitive capture immuno-PCR assay. Proc Natl Acad Sci USA 92: 272-275
46. Sehic E, Szekely M, Ungar AL, Oladelim A, Blatteis CM (1996) Hypothalamic prostaglandin E2 during lipopolysaccharide-induced fever in guinea pigs. Brain Res Bull 39: 391-399
47. Sindhu RK, Sakai H, Okamoto T, Kikkawa Y (1996) Differential effect of interleukin-1α on rat hepatic cytochrome P450 monooxygenases. Toxicology 114: 37-46
48. Stith RD, Templer LA (1994) Peripheral endocrine and metabolic responses to centrally administered interleukin-1. Neuroendocrinology 60: 215-224
49. Terao A, Oikawa M, Saito M (1994) Tissue-specific increase in norepinephrine turnover by central interleukin-1, but not by interleukin-6, in rats. Am J Physiol 266: R400-404
50. Toler SM, Young AB, McClain CJ, Shedlofsky SI, Bandyopadhyay AM, Blouin RA (1993) Head injury and cytochrome P-450 enzymes. Differential effect on mRNA and protein expression in the Fischer-344 rat. Drug Metab Dispos 21: 1064-1069
51. Topfer F, Lenton LM, Bygrave FL, Behm CA (1995) Importance of T-cell-dependent inflammatory reactions in the decline of microsomal cytochrome P450 concentration in the livers of rats infected with Fasciola hepatica. Int J Parasitol 25: 1259-1262
52. Towbin H, Staehlin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76: 4350-4354
53. Wada Y, Sato M, Niimi M, Tumaki M, Ishida T, Takahara J (1995) Inhibitory effects of interleukin-1 on growth hormone secretion in conscious male rats. Endocrinology 136: 3936-3941
54. Waxman DJ, Ram PA, Pampori NA, Shapiro BH (1995) Growth hormone regulation of male-specific rat liver P450s 2A2 and 3A2: induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal monosodium glutamate. Mol Pharmacol 48: 790-797
55. Wermeling DP, Blouin RA, Poter WH, Rapp RP, Tibbs PA (1987) Pentobarbital pharmacokinetics in patients with severe head injury. Drug Intell Clin Pharm 21: 459-463
56. Winstone SE, Fuller SA, Hurrell JGJR (1992) Immunoblotting and immunodetection. In: Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K (eds) Current protocols in molecular biology. Greene Publishing and John Wiley, New York, pp 10.8.1-10.8.16