Characterization of CYP4A induction in rat liver by inflammatory stimuli: Dependence on sex, strain, and inflammation-evoked hypophagia

Drug Metabolism and Disposition

Volumn 29, Issue 1, 2001, Pages 17-22

  Mitchell, Stephanie R ^a,b   Sewer, Marion B ^a,b   Kardar, Sean S ^a   Morgan, Edward T ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 ISOENZYME; MESSENGER RNA;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; FEMALE; FOOD INTAKE; HYPOPHAGIA; INFLAMMATION; LIVER; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; STRAIN DIFFERENCE;

ALKANE 1-MONOOXYGENASE; ANIMALS; BARIUM SULFATE; BASE SEQUENCE; CYTOCHROME P-450 ENZYME SYSTEM; DNA PROBES; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SEX FACTORS; SPECIES SPECIFICITY;

EID: 0035153584     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Northern blot normalization with a 28S rRNA probe
2. Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-a dependent
3. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
4. Differential splicing in the 3′ non-coding region of rat P-452 (P-450 IVA1) mRNA
5. Molecular, enzymatic, and regulatory characterization of rat kidney cytochromes P450 4A2 and 4A3
6. Induction and regulation of cytochrome P450 K-5 (lauric acid hydroxylase) in rat renal microsomes by starvation
7. Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation
8. Lipopolysaccharide induces fever and depresses locomotor activity in unrestrained mice
9. Peroxisome proliferator-activated receptor a controls the hepatic CYP4A induction adaptive response to starvation and diabetes
10. Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
11. Suppression of constitutive cytochrome P-450 gene expression in livers of rats undergoing an acute phase response to endotoxin
12. Regulation of cytochromes P450 during inflammation and infection
13. Kinetic profile of the rat CYP4A isoforms: Arachidonic acid metabolism and isoform-specific inhibitors
14. Endotoxemia in rats is associated with induction of the P4504A subfamily and suppression of several other forms of cytochrome P450
15. Differential inductive and suppressive effects of endotoxin and particulate irritants on hepatic and renal cytochrome P-450 expression
16. Differential induction of peroxisomal and microsomal fatty-acid-oxidising enzymes by peroxisome proliferators in rat liver and kidney. Characterisation of a renal cytochrome P-450 and implications for peroxisome proliferation
17. Changes in amounts of cytochrome P450 isozymes and levels of catalytic activities in hepatic and renal microsomes of rats with streptozocin-induced diabetes
18. Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid omega-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone
19. Fatty acids, eicosanoids, and hypolipidemic agents regulate gene expression through direct binding to peroxisome proliferator-activated receptors
20. Characteristics of dehydroepiandrosterone as a peroxisome proliferator