Down-regulation of cytochrome P450 mRNAS and proteins in mice lacking a functional NOS2 gene

Molecular Pharmacology

Volumn 54, Issue 2, 1998, Pages 273-279

  Sewer, Marion B ^a   Barclay, Thomas B ^a   Morgan, Edward T ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGUANIDINE; CYTOCHROME P450; GENE PRODUCT; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; OXYGENASE; TESTOSTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENDOTOXEMIA; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME MECHANISM; ENZYME POLYMORPHISM; INFLAMMATION; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER CELL; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0031871085     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.54.2.273     Document Type: Article

References (39)

1. Ansher SS and Thompson W (1994) Modulation of hepatic mRNA levels after administration of lipopolysaccharide and diphtheria and tetanus toxoids and pertussis vaccine adsorbed (DTP vaccine) to mice. Hepatology 20:984-991.
2. Cantoni L, Carelli M, Ghezzi P, Delgado R, Faffioni R, and Rizzardini M (1995) Mechanisms of interleukin-2-induced depression of hepatic cytochrome P-450 in mice. Eur J Pharmacol 292:257-263.
3. Carlson TJ and Billings RE (1996) Role of nitric oxide in the cytokine-mediated regulation of cytochrome P-450. Mol Pharmacol 49:796-801.
4. Chen YL, Florentin I, Batt AM, Ferrari L, Giroud JP, and Chauvelot-Moachon L (1992) Effects of interleukin-6 on cytochrome P450-dependent mixed function oxidases in the rat. Biochem Pharmacol 44:137-148.
5. Chen J-Q, Ström A, Gustafsson J-Å, and Morgan ET (1995) Suppression of the constitutive expression of cytochrome P-450 2C11 by cytokines and interferons in primary cultures of rat hepatocytes: comparison with induction of acute-phase genes and demonstration that CYP2C1I promoter sequences are involved in the suppressive response to interleukins 1 and 6. Mol Pharmacol 47:940-947.
6. Chomczynski P and Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
7. Ciaccio PJ and Halpert JR (1989) Characterization of a phenobarbital-inducible dog liver cytochrome P450 structurally related to rat and human enzymes of the P450IIIA (steroid-inducible) gene subfamily. Arch Biochem Biophys 271:284-299.
8. Cribb AE, Delaporte E, Kim SG, Novak RF, and Renton KW (1994) Regulation of cytochrome P-450 1A and cytochrome P-450 2E induction in the rat during the production of interferon α/β. J Pharmacol Exp Ther 268:487-494.
9. Curran, RD, Billiar TR, and Stuehr DJ (1990) Multiple cytokines are required to induce hepatocyte nitric oxide production and inhibit total protein synthesis. Ann Surg 212:462-471.
10. Geller DA, deVera ME, Russell DA, Shapiro RA, Nussler AK, Simmons RL, and Billiar TR (1995) A central role for IL-1β in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase. J Immunol 155:4890-4898.
11. Geller D, Nussler AK, DiSilvio M, Lowenstein CJ, Shapiro RA, Wang SC, Simmons RL, and Billiar TR (1993) Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthases in hepatocytes. Proc Natl Acad Sci USA 90:522-526.
12. Gorodischer R, Larsner J, McDevitt JJ, Nolan JP, and Yaffe SJ (1976) Hepatic microsomal drug metabolism after administration of endotoxin in rats. Biochem Pharmacol 25:351-353.
13. Grisham MB, Johnson GG, and Lancaster JR Jr (1996) Quantitation of nitrate and nitrite in extracellular fluids. Methods Enzymol 268:237-246.
14. Haugen DA and Coon MJ (1976) Properties of electrophoretically homogeneous phenobarbital-inducible forms of liver microsomal cytochrome P-450. J Biol Chem 251:7929-7939.
15. Hodgson PD and Renton KW (1995) The role of nitric oxide generation in interferonevoked cytochrome P450 down-regulation, Int J Immunopharmacol 17:995-1000.
16. Khatsenko OG, Gross SS, Rifkind AB, and Vane JR (1993) Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants. Proc Natl Acad Sci USA 90:11147-11151.
17. Khatsenko O and Kikkawa Y (1997) Nitric oxide affects constitutive cytochrome P450 isoforms in rat liver. J Pharmacol Exp Ther 280:1463-1470.
18. Koop DR (1986) Hydroxylation of p-nitrophenol by rabbit ethanol-inducible cytochrome P-450 isozyme 3a. Mol Pharmacol 29:399-404.
19. Lowry OH, Rosebrough NJ, Farr AF, and Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
20. Minamiyama Y, Takemura S, Imaoka S, Funae Y, Tanimoto, and Inoue M (1997) Irreversible inhibition of cytochrome P450 by nitric oxide. J Pharmacol Exp Ther 283:1479-1485.
21. Monshouwer M, Witkamp RF, Nijmeijer SM, Van Amsterdam JG, and Van Miert AS (1996) Suppression of cytochrome P450-and UDP glucoronosyl transferasedependent enzyme activities by proinflammatory cytokines and possible role of nitric oxide in primary cultures of pig hepatocytes. Toxicol Appl Pharmacol 137: 237-244.
22. Morgan ET (1989) Suppression of constitutive cytochrome P-450 gene expression in livers of rats undergoing an acute phase response to endotoxin. Mol Pharmacol 36:699-707.
23. Morgan ET (1997) Regulation of cytochrome P450 during inflammation and infection. Drug Metab Rev 29:1129-1188.
24. Morgan ET, MacGeoch C, and Gustafsson J-Å (1985) Hormonal and developmental regulation of expression of the hepatic microsomal steroid 16α-hydroxylase cytochrome P-450 apoprotein in the rat. J Biol Chem 260:11895-11898.
25. Morgan ET and Norman CA (1990) Pretranslational suppression of cytochrome P-450h (IIC11) gene expression in rat liver after administration of interferon inducers. Drug Metab Dispos 18:649-653.
26. Morgan ET, Thomas KB, Swanson R, Vales T, Hwang J, and Wright K (1994) Selective suppression of cytochrome P450 gene expression by interleukins 1 and 6 in rat liver. Biochem Biophys Acta 1219:475-483.
27. Omura T and Sato R (1964) The carbon monoxide-binding pigment of liver microsomes. 1. evidence for its hemoprotein nature. J Biol Chem 239:2370-2378.
28. Osawa Y, Davilla JS, Nakasuka M, Meyer CA, and Darbyshire JF (1995) Inhibition of P450 cytochromes by reactive intermediates. Drug Metab Rev 27:61-72.
29. Quaroni L, Reglinski J, Wolf R, and Smith WE (1996) Interaction of nitrogen monoxide with cytochrome P-450 monitored by surface-enhanced resonance Raman scattering. Biochim Biophys Acta 1296:5-8.
30. Sambrook J, Fritsch EF, and Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
31. Sewer MB, Koop DR, and Morgan ET (1996) Endotoxemia in rats is associated with induction of the P4504A subfamily and suppression of several other forms of cytochrome P450. Drug Metab Dispos 24:401-407.
32. Sewer MB, Koop DR, and Morgan ET (1997) Differential inductive and suppressive effects of endotoxin and particulate irritants on hepatic and renal cytochrome P-450 expression. J Pharmacol Exp Ther 280:1445-1454.
33. Sewer MB and Morgan ET (1997) Nitric oxide independent suppression of P-450 2C11 expression by interleukin-1b and endotoxin in primary rat hepatocytes. Biochem Pharmacol 54:729-737.
34. Sewer MB and Morgan ET (1998) Down-regulation of the expression of three major rat liver cytochrome P450s by endotoxin in vivo occurs independently of NO production. J Pharmacol Exp Ther, in press.
35. Stadler J, Trockfeld J, Schmalix WA, Brill T, Siewert JR, Greim H, and Doehmer J (1994) Inhibition of cytochromes P4501A by nitric oxide. Proc Natl Acad Sci USA 91:3559-3563.
36. Stanley LA, Adams DJ, Lindsay R, Meehan RR, Liao W, and Wolf CR (1988) Potentiation and suppression of mouse liver cytochrome P-450 isozymes during the acute-phase response induced by bacterial endotoxin. Eur J Biochem 174:31-36.
37. Tracey WR, Tse J, and Carter G (1995) Lipopolysaccharide-induced changes in plasma nitrite and nitrate concentrations in rats and mice: pharmacological evaluation of nitric oxide synthase inhibitors. J Pharmacol Exp Ther 272:1011-1015.
38. Waxman DJ (1991) P450-catalyzed steroid hydroxylation: assay and product identification by thin-layer chromatography. Methods Enzymol 206:462-476.
39. Wink DA, Osawa Y, Darbyshire JF, Jones CR, Eshenaur SC, and Nims RW (1993) Inhibition of cytochromes P450 by nitric oxide and a nitric oxide-releasing agent. Arch Biochem Biophys 300:115-123.