The role of cutaneous dendritic cells in the immunopathogenesis of atopic dermatitis

British Journal of Dermatology

Volumn 144, Issue 5, 2001, Pages 940-946

  Banfield, Cedric C ^a   Callard, R E ^a   Harper, J I ^a  

^a HINCHINGBROOKE HOSPITAL   (United Kingdom)

Author keywords

Atopic dermatitis; Atopy; Cytokines; Dendritic cells; Langerhans cells; T cells

Indexed keywords

CYTOKINE;

ACUTE DISEASE; ATOPIC DERMATITIS; CELL FUNCTION; CELLULAR DISTRIBUTION; CHRONIC DISEASE; CYTOKINE PRODUCTION; DENDRITIC CELL; IMMUNOPATHOGENESIS; LYMPHOCYTE ACTIVATION; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE;

CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; DERMATITIS, ATOPIC; HUMANS; IMMUNITY, CELLULAR;

EID: 0035725827     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.2001.04179.x     Document Type: Review

References (99)

1. The prevalence of childhood atopic eczema in a general population
2. Prevalence of atopic eczema in the community: The lothian atopic dermatitis study
3. Pathogenesis of atopic dermatitis
4. Atopic dermatitis
5. Pathogenesis of atopic eczema
6. Molecular basis of allergic diseases
7. Atopic dermatitis: Recent trends in pathogenesis and therapy
8. Immune dysregulation in atopic eczema
9. Eosinophils in atopic dermatitis
10. Update on therapy of atopic dermatitis
11. Expression of donor allergic response patterns by bone marrow transplant recipients
12. Granulocyte macrophage colony-stimulating factor contributes to enhanced monocyte survival in chronic atopic dermatitis
13. Interferon-beta mediates stromal cell rescue of T cells from apoptosis
14. Identifying genes predisposing to atopic eczema
15. Association of atopic dermatitis to the beta subunit of the high affinity immunoglobulin E receptor
16. Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families
17. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor
18. Association between variants of mast cell chymase gene and serum IgE levels in eczema
19. No evidence for an association between a variant of the mast cell chymase gene and atopic dermatitis based on case-control and haplotype-relative-risk analyses
20. Morphology of atopic eczema
21. Characterization of the mononuclear cell infiltrate in atopic dermatitis using monoclonal antibodies
22. Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells
23. Differential expression of lymphocyte homing receptors by human memory/effector T cells in pulmonary versus cutaneous immune effector sites
24. Skin-homing T cells in human cutaneous allergic inflammation
25. Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen
26. Regulation of allergic inflammation by skin-homing T cells in allergic eczema
27. Skin-associated lymphocytes in the peripheral blood of patients with atopic dermatitis: Signs of subset expansion and stimulation
28. The quantitative and qualitative defect of CD4+ CD45RO+ memory-type T cells are involved in the abnormality of TH1 immunity in atopic dermatitis patients
29. Predominance of 'memory' T cells (CD4+, CDw29+) over 'naive' T cells (CD4+, CD45R+) in both normal and diseased human skin
30. Human TH1 and TH2 subsets: Doubt no more
31. Mechanisms of deficient interferon-gamma production in atopic diseases
32. Role of T cells in atopic dermatitis. New aspects on the dynamics of cytokine production and the contribution of bacterial superantigens
33. A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis
34. In vivo expression of IL-12 and IL-13 in atopic dermatitis
35. Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis
36. Association of increased CD4+ T-cell infiltration with increased IL-16 gene expression in atopic dermatitis
37. Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis
38. CD8+ cytolytic T lymphocytes and the skin
39. Decreased interferon gamma and increased interleukin-4 production in atopic dermatitis promotes IgE synthesis
40. Enhanced IL-4 production and IL-4 receptor expression in atopic dermatitis and their modulation by interferon-gamma
41. Skin-homing, CLA+ memory T cells are activated in atopic dermatitis and regulate IgE by an IL-13-dominated cytokine pattern: IgG4 counter-regulation by CLA-memory T cells
42. Dendritic cells in allergy
43. Molecular characterization of an autoallergen, Hom s 1, identified by serum IgE from atopic dermatitis patients
44. Evidence for superantigen involvement in skin homing of T cells in atopic dermatitis
45. The role of superantigens in skin disease
46. High frequency of IL-4-producing CD4+ allergen-specific T lymphocytes in atopic dermatitis lesional skin
47. Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen
48. Enhanced expression of eotaxin and CCR3 in atopic dermatitis
49. Increased levels in vivo of mRNAs for IL-8 and macrophage inflammatory protein-1 alpha (MIP-1 alpha), but not of RANTES mRNA in peripheral blood mononuclear cells of patients with atopic dermatitis (AD)
50. Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses
51. CCR5 is characteristic of Th1 lymphocytes
52. Allergen specificity of skin-infiltrating T cells is not restricted to a type-2 cytokine pattern in chronic skin lesions of atopic dermatitis
53. Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial TH2 response to a TH1 response in situ: An immunocytochemical study
54. In vivo expression of cytokine receptor mRNA in atopic dermatitis
55. Dendritic cells and the control of immunity
56. Immunobiology of dendritic cells
57. Dendritic cells in the context of skin immunity
58. Dendritic cells of the skin
59. The role of dendritic cells in cutaneous immunity
60. Dendritic cells
61. Characterization of factor XIIIa positive dermal dendritic cells in normal and inflamed skin
62. Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets
63. Immunomorphological and ultrastructural characterization of Langerhans cells and a novel, inflammatory dendritic epidermal cell (IDEC) population in lesional skin of atopic eczema
64. Activation of human epidermal Langerhans cells by engagement of the high affinity receptor for IgE, Fc epsilon RI
65. The presence of IgE molecules on epidermal Langerhans cells in patients with atopic dermatitis
66. The presence of IgE on macrophages and dendritic cells infiltrating into the skin lesion of atopic dermatitis
67. The high-affinity receptor for IgE is the predominant IgE-binding structure in lesional skin of atopic dermatitis patients
68. Allergen presentation by epidermal Langerhans' cells from patients with atopic dermatitis is mediated by IgE
69. A role for IgE in patch test reactions to inhalant allergens in patients with atopic dermatitis
70. Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation
71. Functional CD86 (B7-2/ B70) is predominantly expressed on Langerhans cells in atopic dermatitis
72. Expression and function of B7-1 (CD80) and B7-2 (CD86) on human epidermal Langerhans cells
73. Dermal dendritic cells associated with T lymphocytes in normal human skin display an activated phenotype
74. Immunoglobulin E-binding structures on antigen-presenting cells present in skin and blood
75. A CD1a+/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells
76. Origin, maturation and antigen presenting function of dendritic cells
77. Dendritic cells: From ontogenetic orphans to myelomonocytic descendants
78. CD34+ cell-derived CD14+ precursor cells develop into Langerhans cells in a TGF-beta 1-dependent manner
79. Transforming growth factor beta 1, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells
80. Monocyte-derived dendritic cells have a phenotype comparable to that of dermal dendritic cells and display ultrastructural granules distinct from Birbeck granules
81. Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking
82. TGF-beta 1 prevents the noncognate maturation of human dendritic Langerhans cells
83. The cytokine profile expressed by human dendritic cells is dependent on cell subtype and mode of activation
84. Functional dichotomy between Langerhans cells that present antigen to naive and to memory/effector T lymphocytes
85. Developmental regulation of dendritic cell function
86. The role of antigen-presenting cells in the regulation of allergen-specific T cell responses
87. Immunological activation of dermal Langerhans cells in contact with lymphocytes in a model of human inflamed skin
88. Reciprocal control of T helper cell and dendritic cell differentiation
89. T cells and dendritic cells get intimate
90. Dendritic cell regulation of Th1-Th2 development
91. Comparison of allergen-stimulated dendritic cells from atopic and nonatopic donors dissecting their effect on autologous naive and memory T helper cells of such donors
92. Helper T-cell responses elicited by Der p 1-pulsed dendritic cells and recombinant IL-12 in atopic and healthy subjects
93. 2 control of T cell cytokine production is functionally related to the reduced lymphocyte proliferation in atopic dermatitis
94. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
95. CC chemokine receptor (CCR) 2 is required for Langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cytokines, B cell outgrowth, and sustained neutrophilic inflammation
96. Macrophage-derived chemokine production by activated human T cells in vitro and in vivo: Preferential association with the production of type 2 cytokines
97. Induction of Th1 and Th2 CD4+ T cell responses: The alternative approaches
98. Transplacental priming of the human immune system to environmental allergens: Universal skewing of initial T cell responses toward the Th2 cytokine profile
99. Development of allergen-specific T-cell memory in atopic and normal children