Interferon-β mediates stromal cell rescue of T cells from apoptosis

European Journal of Immunology

Volumn 29, Issue 3, 1999, Pages 1041-1050

  Pilling, Darrell ^a   Akbar, Arne N ^b   Girdlestone, John ^a   Orteu, Catherine H ^b   Borthwick, Nicola J ^b   Amft, Nicole ^a   Scheel Toellner, Dagmar ^a   Buckley, Christopher D ^a   Salmon, Mike ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Apoptosis; Interferon; Memory; Stromal cell; T lymphocyte

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; PROTEIN BCL 2; PROTEIN BCL X; STAT1 PROTEIN;

APOPTOSIS; ARTICLE; BLAST CELL; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CHRONIC INFLAMMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STROMA CELL; T LYMPHOCYTE;

EID: 0033056851     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1521-4141(199903)29:03<1041::aid-immu1041>3.0.co;2-%23     Document Type: Article

References (49)

1. + T cell in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J.Immunol. 1995. 155: 1032-1036.
2. Ahmed, R. and Gray, D., Immunological memory and protective immuntiy - understanding their relation. Science 1996. 272: 54-60.
3. Tough, D. F., Borrow, P. and Sprent, J., Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 1996. 272: 1947-1950.
4. + T cells in acute infectious mononucleosis. Nature Med. 1996. 2: 906-911.
5. Nagata, S. and Golstein, P., The Fas death factor. Science 1995. 267: 1449-1456.
6. Tough, D. F. and Sprent, J., Viruses and T cell turnover - evidence for bystander proliferation, Immunol. Rev. 1996. 150: 129-142.
7. Akbar, A. N. and Salmon, M., Cellular environments and apoptosis: tissue microenvironments control activated T cell death, Immunol. Today 1997. 18: 72-76.
8. Akbar, A. N., Borthwick, N., Salmon, M., Gombert, W., Bofill, M., Shamsadeen, N., Pilling, D., Pett, S., Grundy, J. E. and Janossy, G., The significance of low Bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory. J. Exp. Med. 1993. 178: 427-438.
9. Orteu, C. H., Poulter, L. W., Rustin, M. H. A., Sabin, C. A., Salmon, M. and Akbar, A. N., The role of apoptosis in the resolution of T cell mediated cutaneous inflammation. J. Immunol. 1998. 161: 1619-1629.
10. Salmon, M., Pilling, D., Borthwick, N. J., Viner, N., Janossy, G., Bacon, P. A. and Akbar, A. N., The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis. Eur. J. Immunol. 1994. 24: 892-899.
11. Akbar, A. N., Borthwick, N. J., Wickremasinghe, R. G., Panayiotidis, P., Pilling, D., Bofill, M., Krajewski, S., Reed, J. C. and Salmon, M., Interleukin-2 receptor cytokine common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal - selective induction of anti-apoptotic (Bcl-2, Bcl-xL) but not pro-apoptotic (Bax, Bcl-xS) geneexpression. Eur. J. Immunol. 1996. 26: 294-299.
12. Salmon, M., Scheel-Toellner, D., Huissoon, A. P., Pilling, D., Shamsadeen, N., Hyde, H., D'Angeac, A. D., Bacon, P. A., Emery, P. and Akbar, A. N., Inhibition of T cell apoptosis in the rheumatoid synovium. J. Clin. Invest. 1997. 99: 439-446.
13. Michie, C. A., McLean, A., Alcock, C. and Beverley, P. C. L., Life-span of human lymphocyte subsets defined by CD45 isoforms. Nature 1992. 360: 264-265.
14. + T Cells from Adults Respond to Recall Antigens after CD28 Ligation. Int. Immunol. 1996. 8: 1737-1742.
15. + T cells during the primary immune response to Epstein Barr virus in vivo. J. Exp. Med. 1998. 187: 1395-1402.
16. Scott, S., Pandolfi, F. and Kurnick, J. T., Fibroblasts mediate T cell survival - a proposed mechanism for retention of primed T cells. J. Exp. Med. 1990. 172: 1873-1876.
17. Gombert, W., Borthwick, N. J., Wallace, D. L., Hyde, H., Bofill, M., Pilling, D., Beverley, P. C. L., Janossy, G., Salmon, M. and Akbar, A. N., Fibroblasts prevent apoptosis of IL-2-deprived T cells without inducing proliferation - a selective effect on Bcl-xL expression. Immunology 1996. 89: 397-404.
18. Cafaro, A., Oliva, A., Polidori, V., Boyle, L. A., Hermann, S., Kurnick, J. T. and Pandolfi, F., Fibroblast-conditioned medium mediates survival of inflammatory cells - different factors are involved in preserving neutrophil and lymphocyte viability. J. Immunol. Res. 1991. 3: 117-122.
19. Lengyel, P., Biochemistry of interferons and their actions. Annu. Rev. Biochem. 1982. 51: 251-282.
20. de Maeyer, E. and de Maeyer-Guignard, J. Interferons and other regulatory cytokines. Wiley-Interscience, New York 1988.
21. Sen, G. C. and Lengyel, P., The interferon system - a birds-eye-view of its biochemistry. J. Biol. Chem. 1992. 267: 5017-5020.
22. O'Shea, J. J., Jaks, stats, cytokine signal transduction, and immunoregulation: are we there yet? Immunity 1997. 7: 1-11.
23. Horvath, C. M. and Darnell, J. E., The state of the STATs: recent developments in the study of signal transduction to the nucleus. Curr. Opin. Cell Biol. 1997. 9: 233-239.
24. Salmon, M., Pilling, D., Borthwick, N. J. and Akbar, A. N., Inhibition of T-Cell Apoptosis: A Mechanism for Persistence in Chronic Inflammation. Immunologist 1997. 5: 87-92.
25. McInnes, I. B., Almughales, J., Field, M., Leung, B. P., Huang, F. P., Dixon, R., Sturrock, R. D., Wilkinson, P. C. and Liew, F. Y., The role of interleukin-15 in T cell migration and activation in rheumatoid arthritis. Nature Med. 1996. 2: 175-182.
26. McInnes, I. B., Leung, B. P., Sturrock, R. D., Field, M. and Liew, F. Y., Interleukin 15 mediates T cell dependent regulation of tumor necrosis factor alpha production in rheumatoid arthritis. Nature Med. 1997. 3: 189-195.
27. Erlandsson, L., Blumenthal, R., Eloranta, M. L., Engel, H., Alm, G., Weiss, S. and Leanderson, T., Interferon-beta is required for interferon-alpha production in mouse fibroblasts. Curr. Biol. 1998. 8: 223-226.
28. Jewell, A. P., Wormann, C. P., Lydyard, P. M., Yong, K. L., Giles, F. J. and Goldstone, A. H., Interferon-alpha up-regulates bcl-2 expression and protects B-CLL cells from apoptosis in vitro and in vivo. Br. J. Haematol. 1994. 88: 268-274.
29. Panayiotidis, P., Ganeshaguru, K., Jabbar, S. A. B. and Hoffbrand, A. V., Alpha-interferon (α-IFN) protects B-chronic lymphocytic-leukemia cells from apoptotic cell death in vitro. Br. J. Haematol. 1994. 86: 169-173.
30. Milner, A. E., Grand, R. J. A. and Gregory, C. D., Effects of interferon-alpha on human B-cells - repression of apoptosis and prevention of cell-growth are independent responses of burkitt-lymphoma lines. Int. J. Cancer 1995. 61: 348-354.
31. Kaneko, S., Suzuki, N., Koizumi, H., Yamamoto, S. and Sakane, T., Rescue by cytokines of apoptotic cell death induced by IL 2 deprivation of human antigen specific T cell clones. Clin. Exp. Immunol. 1997. 109: 185-193.
32. Egle, A., Villunger, A., Kos, M., Bock, G., Gruber, J., Auer, B. and Greil, R., Modulation of Apo-1/Fas (CD95)-induced programmed cell death in myeloma cells by interferon-alpha 2. Eur. J. Immunol. 1996. 26: 3119-3126.
33. Oehen, S., Waldner, H., Kundig, T. M., Hengartner, H. and Zinkernagel, R. M., Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen. J. Exp. Med. 1992. 176: 1273-1281.
34. + T cell memory determined by clonal burst size. Nature 1994. 369: 652-654.
35. Lau, L. L., Jamieson, B. D., Somasundaram, T. and Ahmed, R., Cytotoxic T cell memory without antigen. Nature 1994. 369: 648-652.
36. Müllbacher, A., The long-term maintenance of cytotoxic T cell memory does not require persistence of antigen. J. Exp. Med. 1994. 179: 317-321.
37. Sprent, J., Immunological memory. Curr. Opin. Immunol. 1997. 9: 371-379.
38. + T cells in vivo by IL-15. Immunity 1998. 8: 591-599.
39. Unutmaz, D., Pileri, P. and Abrignani, S., Antigen independent activation of naive and memory resting T cells by a cytokine combination. J. Exp. Med. 1994. 180: 1159-1164.
40. Fassbender, H. G. Pathology of Rheumatic Diseases. Springer-Verlag, New York 1975.
41. Hopkins, S. J. and Meager, A., Cytokines in synovial fluid: II. The presence of tumour necrosis factor and interferon. Clin. Exp. Immunol. 1988. 73: 88-92.
42. Feldmann, M., Brennan, F. M. and Maini, R. N., Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 1996. 14: 397-440.
43. + T lymphocytes in rheumatoid arthritis. Eur. J. Immunol. 1998. 28: 2661-2671.
44. Shah, M. H., Hackshaw, K. V. and Caligiuri, M. A., A role for IL-15 in rheumatoid arthritis? Nature Med. 1998. 4: 643-643.
45. Sengupta, T. K., Chen, A., Zhong, Z., Darnell, J. E. and Ivashkiv, L. B., Activation of monocyte effector genes and STAT family transcription factors by inflammatory synovial fluid is independent of interferon-gamma. J. Exp. Med. 1995. 181: 1015-1025.
46. Wang, F., Sengupta, T. K., Zhong, Z. and Ivashkiv, L. B., Regulation of the balance of cytokine production and the signal transducer and activator of transcription (STAT) transcription factor activity by cytokines and inflammatory synovial fluids. J. Exp. Med. 1995. 182: 1825-1831.
47. Schneider, C., Gold, R., Dalakas, M. C., Schmeid, R., Lassmann, H., Toyka, K. V. and Hartung, H. P., MHC Class-l mediated cytotoxicity does not induce apoptosis in muscle fibres nor in inflammatory T cells - Studies in patients with polymyositis, dermatomyositis and inclusion body myositis. J. Neuropathol. Exp. Neurol. 1996. 55: 1205-1209.
48. Crowston, J. G., Salmon, M., Khaw, P. T. and Akbar, A. N., T-lymphocyte-fibroblast interactions. Biochem. Soc. Trans. 1997. 25: 529-531.
49. Girdlestone, J. and Wing, M., Autocrine activation by interferon-gamma of STAT factors following T cell activation. Eur. J. Immunol. 1996. 26: 704-709.