Developmental regulation of dendritic cell function

Current Opinion in Immunology

Volumn 11, Issue 3, 1999, Pages 308-313

  Lane, Peter J L ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN RECOGNITION; CELL DIFFERENTIATION; CELL MIGRATION; DENDRITIC CELL; DEVELOPMENT; HUMAN; IMMUNE RESPONSE; LYMPHOID ORGAN; NONHUMAN; ONTOGENY; REVIEW;

EID: 0032988982     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(99)80049-1     Document Type: Article

References (4)

1. Bjorck P, Kincade PW: CD19+ pro-B cells can give rise to dendritic cells in vitro. J Immunol 1998, 161:5795-5799.
2. Brossart P, Grunebach F, Stuhler G, Reichardt VL, Mohle R, Kanz L, Brugger W: Generation of functional human dendritic cells from adherent peripheral blood monocytes by CD40 ligation in the absence of granulocyte-macrophage colony-stimulating factor [in process citation]. Blood 1998, 92:4238-4247.
3. Randolph GJ, Beaulieu S, Lebecque S, Steinman RM, Muller WA: Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking. Science 1998, 282:480-483. This work shows that monocytes have at least two potential fates: either they give rise to (myeloid) DCs by transendothelial migration or they become macrophages if they stay in the subendothelial matrix.
4. Albert ML, Sauter B, Bhardwaj N: Dendritic cells acquire antigen from apoptotic cells and induce class I restricted CTLs. Nature 1998, 392:86-89. Albert et al. demonstrate that DCs, but not macrophages, are able to acquire exogenous antigen from apoptotic cells and present it efficiently on MHC class I molecules. This would explain how exogenous material gets access to the endogenous pathway of antigen-presentation and offers one potential explanation for the phenomenon of cross-presentation.