Regulation of allergic inflammation by skin-homing T cells in allergic eczema

International Archives of Allergy and Immunology

Volumn 118, Issue 2-4, 1999, Pages 140-144

  Akdis, Cezmi A ^a   Akdis, Mübeccel ^a   Simon, Hans Uwe ^a   Blaser, Kurt ^a  

^a SWISS INSTITUTE OF ALLERGY AND ASTHMA RESEARCH SIAF   (Switzerland)

Author keywords

Atopic dermatitis; Cutaneous lymphocyte associated antigen; Eosinophils; Immunoglobulin E; Interleukin 13; Interleukin 5; Skin homing; T cells

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G4; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR;

APOPTOSIS; ATOPIC DERMATITIS; B LYMPHOCYTE; CELL SURVIVAL; CONFERENCE PAPER; CONTACT DERMATITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; EOSINOPHIL; EOSINOPHILIA; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE; LYMPHOCYTE MIGRATION; LYMPHOCYTE PROLIFERATION; MEMORY CELL; NORMAL HUMAN; PRIORITY JOURNAL; SKIN; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

EID: 0032915975     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000024051     Document Type: Conference Paper

References (23)

1. Bos JD, Kapsenberg ML: The skin immune system: Progress in cutaneous biology. Immunol Today 1993;14:75-79.
2. Picker LJ, Michie SA, Rott LS, Butcher EC: A unique phenotype of skin associated lymphocytes in humans: Preferential expression of the HECA-452 epitope by benign and malignant T-cells at cutaneous sites. Am J Pathol 1990; 136:1053-1061.
3. Picker LJ, Treer JR, Ferguson-Darnell B, Collins PA, Bergstresser PR, Terstappen LWMM: Control of lymphocyte recirculation in man. III. Differential regulation of the cutaneous lymphocyte-associated antigen, a tissue selective homing receptor for skin-homing T cells. J Immunol 1993;150:1122-1136.
4. Akdis M, Akdis CA, Weigl L, Disch R, Blaser K: Skin-homing, CLA+ memory T cells are activated in atopic dermatitis and regulate IgE by an IL-13-dominated cytokine pattern. IgG4 counter-regulation by CLA-memory T cells. J Immunol 1997;159:4611-4619.
5. Santamaria Babi LF, Moser R, Perez Soler MT, Picker LJ, Blaser K, Hauser C: The migration of skin-homing T cells across cytokine-activated human endothelial cell layers involves interaction of the cutaneous lymphocyte-associated antigen (CLA), the very late antigen-4 (VLA-4) and the lymphocyte function-associated antigen-1 (LFA-1). J Immunol 1995;154; 1443-1550.
6. Picker LJ, Kishimoto TK, Smith CW, Warnock RA, Butcher EC: ELAM-1 is an adhesion molecule for skin-homing T cells. Nature 1991;349:796-799.
7. Fuhlbrigge RC, Kieffer JD, Armerding D, Kupper TS: Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Nature 1997;389:978-981.
8. Sanatmaria Babi LF, Picker LJ, Perez Soler MT, Drzimalla K, Flohr P, Blaser K, Hauser C: Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen. J Exp Med 1995;181: 1935-1940.
9. Santamaria Babi LF, Moser B, Perez Soler MT, Moser R, Loetscher P, Villiger B, Blaser K, Hauser C: The interleukin-8 receptor B and CXC chemokines can mediate transendothelial migration of human skin homing T cells. Eur J Immunol 1996;26:2056-2961.
10. 2 results in the secretion of Th1 orTh2 like cytokine patterns. Clin Exp Allergy 1995;25:1108-1117.
11. Akdis M, Akdis CA, Weigl L, Disch R, Simon H-U. Blaser K: In vivo activated skin homing (CLA+) T cells in atopic dermatitis spontaneously secrete an IL-5 and IL-13 dominated Th2 cytokine pattern, help eosinophil survival and induce IgE production. J Allergy Clin Immunol 1998;101:164.
12. 2 in vitro. J Allergy Clin Immunol 1994;93:758-767.
13. Akdis CA, Blesken T, Akdis M, Alkan SS, Wüthrich B, Heusser CH, Blaser K: Induction and differential regulation of bee venom phospholipase A2-specific human IgE and IgG4 antibodies in vitro requires allergen-specific and nonspecific activation of T and B cells. J Allergy Clin Immunol 1997;99:345-352.
14. Punnonen J, Aversa G, Cocks BG, McKenzie ANJ, Menon S, Zurawski G, De Waal Malefyt R, De Vries JE: Interleukin 13 induces interleukin 4 independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 1988;90:3730-3734.
15. Zhang X, Polla B, Hauser C, Zubler RH: T cells from atopic individuals produce an IgE inducing activity incompletely blocked by anti-interleukin-4 antibody. Eur J Immunol 1992; 22:829-833.
16. Leung DYM: Immunopathology of atopic dermatitis. Springer Semin Immunopathol 1992; 13:427-440.
17. Walker C, Virchow J-C, Bruijnzeel PLB, Blaser K: T cell subsets and their soluble products regulate eosinophilia in allergic and non-allergic asthma. J Immunol 1991;146:1829-1835.
18. Simon H-U, Yousefi S, Schranz C, Schapowal A, Bachert C, Blaser K: Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia. J Immunol 1997;158:3902-3908.
19. Varney VA, Hamid QA, Gaga M, Ying S, Jacobson M, Frew AJ, Kay AB, Durham SR: Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. J Clin Invest 1993;92: 644-651.
20. Van der Heijden FL, Wierenga EA, Bos JD, Kapsenberg ML: High frequency of IL-4-producing CD4+ allergen-specific T lymphocytes in atopic dermatitis lesional skin. J Invest Dermatol 1991;97:389-394.
21. Kemeny DM, Noble A, Holmes BJ, Diaz Sanches D: Immune regulation: A new role for CD8+ T cell. Immunol Today 1994;15:107-110.
22. Punnonen J, Yssel H, De Vries JE: The relative contribution of IL-4 and IL-13 to human IgE synthesis induced by activated CD4+ or CD8+ T cells. J Allergy Clin Immunol 1997;100: 792-801.
23. Renz H, Lack G, Saloga J, Schwinzer R, Bradley K, Loader J, Larsen G, Gelfand E: Inhibition of IgE production and normalization of airway responsiveness by sensitized CD8 T cells in a mouse model of allergen induced sensitization. J Immunol 1994;152:351-360.