In vivo expression of IL-12 and IL-13 in atopic dermatitis

Journal of Allergy and Clinical Immunology

Volumn 98, Issue 1, 1996, Pages 225-231

  Hamid, Qutayba ^a   Naseer, Tanveer ^a   Minshall, Eleanor M ^a   Song, Yan L ^a   Boguniewicz, Mark ^b   Leung, Donald Y M ^b  

^a MCGILL UNIVERSITY   (Canada)

^b NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

allergic inflammation; atopic dermatitis; IL 12; IL 13; T lymphocytes

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 13; MESSENGER RNA;

ADULT; ARTICLE; ATOPIC DERMATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; HELPER CELL; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; PRIORITY JOURNAL; SKIN BIOPSY; T LYMPHOCYTE;

EID: 0029783367     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(96)70246-4     Document Type: Article

References (22)

1. Hanifin JM. Atopic dermatitis. J Allergy Clin Immunol 1984;73:211-22.
2. Leung DYM, Bhan AK, Schneeberger EE, Geha RS. Characterization of the mononuclear cell infiltrate in atopic dermatitis using monoclonal antibodies. J Allergy Clin Immunol 1983;71:47-56.
3. Hamid Q, Boguniewicz M, Leung DYM. Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis. J Clin Invest 1994;94:870-5.
4. Ohmen JD, Hanifin JM, Nickoloff BJ, et al. Overexpression of IL-10 in atopic dermatitis: contrasting cytokine patterns with delayed-type hypersensitivity reactions. J Immunol 1995;154:1956-63.
5. Manetti R, Parronchi P, Giudizi MG, et al. Natural killer cell stimulatory factor (interleukin 12; IL-12) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4 producing Th cells. J Exp Med 1993;177:1199-204.
6. Kiniwa M, Gately M, Gubler U, Chizzonite R, Fargeas C, Delespesse G. Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes. J Clin Invest 1992;90:262-6.
7. Zurawski G, de Vries JE. Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol Today 1994;15:19-26.
8. Tsicopoulous A, Hamid Q, Varney V, et al. Preferential messenger RNA expression of Th1-type cells (IFNγ+, IL-2+) in classical delayed-type (tuberculin) hypersensitivity reactions in human skin. J Immunol 1992;148:2058-61.
9. Varney VA, Hamid QA, Gaga M, et al. Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. J Clin Invest 1993;92:644-51.
10. Van der Heijden FL, Wierenga EA, Bos JD, Kapsenberg ML. High frequency of IL-4 producing CD4+ allergen specific T lymphocytes in atopic dermatitis lesional skin. J Invest Dermatol 1991;97:389-94.
11. Naseer T, Leung DYM, Song Y, Martin R, Hamid Q. Expression of IL-12 mRNA in baseline asthma and in response to steroid therapy [abstract]. Am J Respir Crit Care Med 1995;151:A701.
12. Burd PR, Thompson WC, Max EE, Mills FC. Activated mast cells produce interleukin 13. J Exp Med 1995;181: 1373-80.
13. Hamid Q, Ernst P. Increased expression of IL-13 mRNA in atopic asthma: evidence of colocalizationwith IL-4. Presented at Asthma '95: Theory to Treatment; July 1995; Chicago, IL.
14. Leung DYM. Immunopathology of atopic dermatitis. Springer Semin Immunopathol 1992;13:427-40.
15. McKenzie ANJ, Culpepper JA, de Waal Malefyt RD, et al. Interleukin-13, a T cell derived cytokine that regulates human monocyte and B cell function. Proc Natl Acad Sci USA 1993;90:3735-9.
16. Defrance T, Carayon P, Billian G, et al. Interleukin 13 is a B cell stimulating factor. J Exp Med 1994;179:135-43.
17. Bochner BS, Klunk DA, Sterbinsky SA, Coffman RL, Schleimer RP. IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells. J Immunol 1995;154:799-803.
18. Bette M, Jin SC, Germann T, Schafer MK, Weihe E, Rude E, Fleischer B. Differential expression of mRNA encoding interleukin-12 p35 and p40 subunits in situ. Eur J Immunol 1994;24:2435-40.
19. Durham SR, Schotman E, Jacobson M, Walker S, Hamid Q. Grass pollen immunotherapy (IT): inhibition of allergen-induced late skin responses (LPR) is associated with an increase in IL-12 messenger RNA+ cells [abstract]. J Allergy Clin Immunol 1995;95:304.
20. Chan SH, Perussia B, Gupta JW, et al. Induction of interferon-gamma production by natural killer cell stimulatory factor: characterization of the responding cells and synergy with other inducers. J Exp Med 1991;173:869-79.
21. Chan SC, Kim JW, Henderson WR Jr, Hanifin JM. Altered prostaglandin E2 regulation of cytokine production in atopic dermatitis. J Immunol 1993;151:3345-52.
22. γ response in atopic dermatitis. J Immunol 1995;154: 6174-81.