CD34+ cell-derived CD14+ precursor cells develop into Langerhans cells in a TGF-β1-dependent manner

Journal of Immunology

Volumn 163, Issue 9, 1999, Pages 4869-4877

  Jaksits, Silvia ^a   Kriehuber, Ernst ^a   Charbonnier, Anne Sophie ^a   Rappersberger, Klemens ^a   Stingl, Georg ^a   Maurer, Dieter ^a  

^a Universitatsklinik fur Dermatologie   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 13A; CD1 ANTIGEN; CD11 ANTIGEN; CD14 ANTIGEN; CD34 ANTIGEN; CD36 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UVOMORULIN;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; DENDRITIC CELL; IMMUNOSTIMULATION; LANGERHANS CELL; MACROPHAGE; PRIORITY JOURNAL; T LYMPHOCYTE;

ADULT; ANTIGENS, CD1; ANTIGENS, CD14; ANTIGENS, CD34; ANTIGENS, SURFACE; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; CYTOPLASMIC GRANULES; DENDRITIC CELLS; FETAL BLOOD; HEMATOPOIETIC STEM CELLS; HUMANS; INTERPHASE; LANGERHANS CELLS; LYMPHOCYTE ACTIVATION; MACROPHAGES; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA;

EID: 0032751202     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Stingl, G., D. Maurer, C. Hauser, and K. Wolff. 1999. The epidermis: an immunologic microenvironment. In Dermatology in General Medicine, Vol. 1. I. M. Freedberg, A. Z. Eisen, K. Wolff, K. F. Austen, L. A. Goldsmith, S. I. Katz, and T. B. Fitzpatrick, eds. McGraw-Hill, New York, p. 343.
2. Maurer, D., and G. Stingl. 1999. Dendritic cells in the context of skin immunity. In Dendritic Cells. M. T. Lotze, and A. W. Thompson, eds. Academic Press, San Diego, p. 111.
3. Caux, C., D. C. Dezutter, D. Schmitt, and J. Banchereau. 1992. GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells. Nature 360: 258.
4. + hematopoietic progenitor cells. Blood 87:1292.
5. + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF + TNFα. J. Exp. Med 184:695.
6. + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF plus TNFα. II. Functional analysis. Blood 90:1458.
7. Neslle, F. O., X. G. Zheng, C. B. Thompson, L. A. Turka, and B. J. Nickoloff. 1993. Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets. J Immunol. 151: 6535.
8. de Saint-Vis, B., V. I. Fugier, C. Massacrier, C. Gaillard, B. Vanbervliet, Y. S. Ait, J. Banchereau, Y. J. Liu, S. Lebecque, and C. Caux. 1998. The cytokine profile expressed by human dendritic cells is dependent on cell subtype and mode of activation. J. Immunol. 160:1666.
9. + blood progenitors for anticancer therapy. Exp. Hematol. 23:1463.
10. + bone marrow precursors cultured with c-kit ligand, granulocyte-macrophage colony-stimulating factor, and TNF-β. J. Immunol. 154:5851.
11. Borkowski, T. A., J. J. Letterio, A. G. Farr, and M. C. Udey. 1996. A role for endogenous transforming growth factor β1 in Langerhans cell biology: the skin of transforming growih factor β1 null mice is devoid of epidermal Langerhans cells. J. Exp. Med. 184:2417.
12. + hemopoietic progenitors. J. Immunol. 157:1499
13. Riedl, E., H. Strobl, O. Majdic, and W. Knapp. 1997. TGF-β1 promotes in vitro generation of dendritic cells by protecting progenitor cells from apoptosis. J. Immunol. 158:1591.
14. Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyle/macrophage colony-stimulating factor plus interleukin 4 and down-regulated by tumor necrosis factor α. J. Exp. Med. 179:1109.
15. Romani, N., S. Gruner, D. Brang, E. Kämpgen, A. Lenz, B. Trockenbacher, G. Konwalinka, P. O. Fritsch, R. M. Steinman, and G. Schuler. 1994. Proliferating dendritic cell progenitors in human blood. J. Exp. Med. 180:83.
16. Maurer, D., E. Fiebiger, B. Reininger, B. Wolff-Winiski, M-H. Jouvin, O. Kilgus, J.-P. Kinet, and G. Stingl. 1994. Expression of functional high affinity immunoglobulin E receptors (Fc∈RI) on monocytes of atopic individuals. J. Exp. Med. 179:745.
17. Maurer, D., E. Fiebiger, C. Ebner, B. Reininger, G. F. Fischer, S. Wichlas, M.-H. Jouvin, M. Schmitt-Egenolf, D. Kraft, J.-P. Kinet, et al. 1996. Peripheral blood dendritic cells express Fc∈RI as a complex composed of Fc∈RIα- and Fc∈RIα-chains and can use this receptor for IgE-mediated allergen presentation. J. Immunol. 157:607.
18. Lyons, A. B., and C. R. Parish. 1994. Determination of lymphocyte division by flow cytometry. J. Immunol. Methods 171:131.
19. Hodgkin, P. D., J. H. Lee, and A. B. Lyons. 1996. B cell differentiation and isotype switching is related to division cycle number. J. Exp. Med. 184:277.
20. Wells, A. T., H. Gudmundsdottir, and L. A. Turka. 1997. Following the fate of individual T cells throughout activation and clonal expansion. J. Clin. Invest. 100:3173.
21. Gudmundsdottir, H., A. T. Wells, and L. A. Turka. 1999. Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity. J. Immunol. 162:5212.
22. Geissmann, F., C. Prost, J. P. Monnet, M. Dy, N. Brousse, and O. Hermine. 1998. Transforming growth factor β1 in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells. J. Exp. Med. 187:961.
23. Geissmann, F., P. Revy, A. Regnault, Y. Lepelletier, M. Dy. N. Brousse, S. Amigorena, O. Hermine, and A. Durandy. 1999. TGF-β1 prevents the noncognate maturation of human dendritic Langerhans cells. J. Immunol. 162:4567.
24. Borkowski, T. A., J. J. Letterio, C. L. Mackall, A. Saitoh, X. J. Wang, D. R. Roop, R. E. Gress, and M. C. Udey. 1997. A role forTGFβ1 in Langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFβ1 null mice. J. Clin. Invest. 100:575.
25. Roberts, A. B., and M. B. Sporn. 1990. Peptide growth factors and their receptors. In The Transforming Growth Factor βs, Vol. I. A. B. Roberts, and M. B. Sporn, eds. Springer Verlag, Berlin, p. 419.
26. Barnard, J. A., R. M. Lyons, and H. L. Moses. 1990. The cell biology of transforming growth factor β. Biochim. Biophys. Acta 1032:79.
27. Strunk, D., C. Egger, G. Leitner, D. Hanau, and G. Stingl. 1997. A skin homing molecule defines the Langerhans cell progenitor in human peripheral blood. J. Exp. Med 185:1131.