Impaired motor learning performance in cerebellar En-2 mutant mice

Behavioral Neuroscience

Volumn 110, Issue 1, 1996, Pages 126-133

  Gerlai, R ^a   Herrup, K ^c   Fabien, K ^c   Millen, K J ^b   Joyner, A L ^d   Roder, J ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

^b ROCKEFELLER UNIVERSITY   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CEREBELLUM; CONTROLLED STUDY; FEMALE; GENE MUTATION; HABITUATION; LEARNING; MALE; MOTOR PERFORMANCE; MOUSE; NEUROANATOMY; NONHUMAN;

EID: 9044254932     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/0735-7044.110.1.126     Document Type: Article

References (41)

1. Aiba, A., Kano, M., Chen, C., Stanton, M. E., Fox, G. D., Herrup, K., Zwingman, T. A., & Tonegawa, S. (1994). Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice. Cell, 79, 377-388.
2. Altman, J. (1982). Morphological development of the rat cerebellum and some of its mechanisms. In S. L. Palay & V. Chan-Palay (Eds.), The cerebellum: New vistas (pp. 8-49). Berlin: Springer-Verlag.
3. Altman, J. (1987). Morphological and behavioral markers of environmentally induced retardation of brain development: An animal model. Environmental Health Perspectives, 74, 153-168.
4. Archer, J. (1973). Tests for emotionality in rats and mice. A review. Animal Behaviour, 2, 205-235.
5. Artola, A., & Singer, W. (1993). Long-term depression of excitatory synaptic transmission and its relationship to long-term potentiation. TINS 11, 480-487.
6. Balaban, C. D., Fredericks, D. A., Wurpel, J. N. D., & Severs, W. (1988). Motor disturbances and neurotoxicity induced by centrally administered somatostatin and vasopressin in conscious rats: interactive effects of two neuropeptides. Brain Research, 445, 117-129.
7. Crusio, W. E., Schwegler, H., & van Abeelen, J. H. F. (1989). Behavioral responses to novelty and structural variation of the hippocampus in mice: I. Quantitative-genetic analysis of behavior in the open-field. Behavioural Brain Research, 2, 75-80.
8. Crusio, W. E., & van Abeelen, J. H. F. (1986). The genetic architecture of behavioral responses to novelty in mice. Heredity, 56, 55-63.
9. Davidson, D., Graham, E., Sime, C., & Hill, R. (1988). A gene with sequence similarity to Drosophila engrailed is expressed during the development of the neural tube and vertebrae in the mouse. Development, 104, 305-316.
10. Davis, C. A., Noble-Topham, S. E., Rossant, J., & Joyner, A. L. (1988). Expression of the homeo box-containing gene En-delineates a specific region of the developing mouse brain. Genes and Development, 2, 361-371.
11. Davis, C. A., & Joyner, A. L. (1988). Expression patterns of the homeo box containing genes EN-1 and En-2 and the proto-oncogene int-1 diverge during mouse development. Genes and Development, 2, 1736-1744.
12. Eysenck, H. J., & Broadhurst, P. L. (1964). Experiments with animals: Introduction. In H. J. Eysenck (Ed.), Experiments in motivation (pp. 285-291). New York: Macmillan.
13. Garcia-Bellido, A., & Santamaria, P. (1972). Developmental analysis of the wing disc in the mutant engrailed of Drosophila melanogaster. Genetics, 72, 87-104.
14. Gerlai, R., Friend, W., Becker, L., O'Hanlon, D., Marks, A., & Roder, J. (1993). Female transgenic mice carrying the human gene for S100β are hyperactive. Behavioural Brain Research, 55, 51-59.
15. Gerlai, R., & Hogan, J. A. (1992). Learning to find the opponent: An ethological analysis of the behavior of paradise fish (Macropodus opercularis, Anabantidae) in intra- and inter-specific encounters. Journal of Comparative Psychology, 106, 306-315.
16. Ghez, C. (1991). The cerebellum. In E. R. Kandell, J. H. Schwartz, & T. M. Jessell (Eds.), Principles of neural science (3rd ed., pp. 626-647). Englewood Cliffs, NJ: Prentice Hall.
17. Gilman, S., Bloedel, J. R., & Lechtenberg, R. (Eds.). (1981). Disorders of the cerebellum. Philadelphia: Davis F. A.
18. Goldowitz, D., & Koch, J. (1986). Performance of normal and neurological mutant mice on radial arm maze and active avoidance tasks. Behavioral and Neural Biology, 46, 216-226.
19. Huntingford, F. (1984). The study of animal behaviour. London: Chapman and Hall.
20. Joyner, A. L., Kornberg, T., Coleman, K. G., Cox, D. R., & Martin, G. R. (1985). Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene. Cell, 43, 29-37.
21. Joyner, A. L., Skarnes, W. C., & Rossant, J. (1989). Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells. Nature, 338, 153-156.
22. Joyner, A. L., Herrup, K., Auerbach, B. A., Davis, C. A., & Rossant, J. (1991, March 8). Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. Science, 251, 1239-1243.
23. Lalonde, R., & Botez, M. I. (1990). The cerebellum and learning processes in animals. Brain Research Review, 15, 325-332.
24. Lalonde, R., Botez, M. I., & Boivin, D. (1986). Spontaneous alternation and habituation in a t-maze in nervous mutant mice. Behavioral Neuroscience, 100, 350-352.
25. Lawrence, P. A., & Johnson, P. (1984). On the role of engrailed gene in the internal organs of Drosophila. EMBO Journal, 3, 2839-2844.
26. Lawrence, P. A., & Morata, G. (1976). Compartments in the wing of Drosophila: a study of the engrailed gene. Developmental Biology, 86, 363-372.
27. Lawrence, P. A., & Struhl, G. (1982). Further studies of the engrailed phenotype in Drosophila. EMBO Journal, 1, 827-833.
28. Leaton, R. N., & Supple, W. F., Jr. (1991). Medial cerebellum and long-term habituation of acoustic startle in rats. Behavioral Neuroscience, 105, 804-816.
29. Leaton, R. N., Cassella, J. V., & Borszcz, G. S. (1985). Short-term and long-term habituation of the acoustic startle response in chronic decerebrate rats. Behavioral Neuroscience, 100, 443-454.
30. Li, C., Tropak, B., Gerlai, R., Clapoff, S., Abramow-Newerly, W., Trapp, B., Peterson, A., & Roder, J. (1994). Inactivation of the MAG gene impairs the organization of the periaxonal region in myelin. Nature, 369, 747-750.
31. Llinas, R., & Welsh, J. P. (1993). On the cerebellum and motor learning. Current Opinion in Neurobiology, 3, 958-965.
32. Logan, C., Hanks, M. C., Noble-Topham, S., Nallainathan, D., Povart, N. J., & Joyner, A. L. (1992). Cloning and sequence comparison of the mouse, human and chicken engrailed genes reveal potential functional domains and regulatory regions. Developmental Genetics 13, 345-358.
33. Kornberg, T. (1981). Engrailed: A gene controlling compartment and segment formation in Drosophila. Proceedings of the National Academy of Sciences (USA), 78, 1095-1099.
34. Willen, K. J., Wurst, W., Herrup, K., & Joyner, A. L. (1994). Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants. Development, 120, 695-706.
35. Njolstad, P. R., & Fjose, A. (1988). In situ hybridization patterns of zebrafish homeobox genes homologous to Hox 2.1 and En-2 of mouse. Biochemical and Biophysical Research Communications, 157, 426-432.
36. Patel, N. H., Martin-Blanco, E., Coleman, K. G., Poole, S. J., Ellis, M. C., Kornberg, T. B., & Goodman, C. S. (1989). Expression of engrailed proteins in arthropods, annelids and chordates. Cell, 58, 955-968.
37. Pellegrino, L. J., & Altman, J. (1979). Effects of differential interference with postnatal cerebellar neurogenesis on motor performance, activity level, and maze learning of rats: a developmental study. Journal of Comparative Physiological Psychology, 93, 1-33.
38. Phillips, T. J., & Crabbe, J. C., Jr. (1991). Behavioral studies of genetic differences in alcohol action. In J. C. Crabbe & R. A. Harris (Eds.), The genetic basis of alcohol and drug actions (pp. 25-104). New York: Plenum Press.
39. Smithies, O. (1993). Animal models of human genetic disease. Trends in Genetics, 9, 112-116.
40. van Abeelen, J. H. F. (1963). Mouse mutants studied by means of ethological methods: I. Ethogram. Genetica, 34, 79-94.
41. Welker, W. I. S. (1990). The significance of foliation and fissuration of the cerebellar cortex: The cerebellar folium as a fundamental unit of sensorimotor integration. Archives of Italian Biology, 128, 87-109.