Nucleocytoplasmic transport enters the atomic age

Current Opinion in Cell Biology

Volumn 13, Issue 3, 2001, Pages 310-319

  Conti, E ^a   Izaurralde, E ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; KARYOPHERIN; MESSENGER RNA;

CELL NUCLEUS MEMBRANE; CRYSTAL STRUCTURE; CYTOPLASM; GENE TRANSLOCATION; INTRACELLULAR TRANSPORT; MEMBRANE CHANNEL; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN TRANSPORT; REVIEW; RNA SPLICING;

EID: 0035370948     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(00)00213-1     Document Type: Review

References (63)

1. Transport between the cell nucleus and the cytoplasm
2. Nucleocytoplasmic transport: The soluble phase
3. Transport routes through the nuclear pore complex
4. Transport of proteins and RNAs in and out of the nucleus
5. Importins and exportins: How to get in and out of the nucleus
6. A 41 amino acid motif in importin-α confers binding to importin-β and hence transit into the nucleus
7. The conserved amino-terminal domain of hSRP1 alpha is essential for nuclear protein import
8. Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells
9. Importin beta mediates nuclear translocation of Smad 3
10. Interactions between HIV Rev and nuclear import and export factors: The Rev nuclear localisation signal mediates specific binding to human importin-beta
11. The arginine-rich domains present in human immunodeficiency virus type I Tat and Rev functions as direct importin β-dependent nuclear localization signals
12. The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1
13. A distinct nuclear import pathway used by ribosomal proteins
14. Comparison of ARM and HEAT protein repeats
15. Structure of importin-β bound to the IBB domain of importin-α
16. Structure of the nuclear transport complex karyopherin-β2-GppNHp
17. Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin α
18. Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin α
19. A repeating amino acid motif shared by proteins with diverse cellular roles
20. Evolutionary specialization of the nuclear targeting apparatus
21. Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin α
22. Structural basis of recognition of monopartite and bipartite nuclear localization sequence in mammalian importin α
23. Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form
24. Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: Implications for nuclear transport
25. Structural view of the Ran-Importin β interaction at 2.3 Å resolution
26. Dissection of a nuclear localization signal
27. The nuclear pore complex: A protein machine bridging the nucleus and cytoplasm
28. Structural basis for the interaction between FxFG nucleoporin repeats and importin β in nuclear trafficking
29. The yeast nuclear pore complex: Composition, architecture, and transport mechanism
30. Kinetic analysis of translocation through nuclear pore complexes
31. Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran
32. The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates
33. TAP/NXF1 belongs to a multigene family of putative RNA export factors with a conserved modular architecture
34. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human
35. Identification of novel import and export signals of human TAP, the protein that binds to the CTE element of the type D retrovirus mRNAs
36. The GLFG region of Nup116p and Nup100p serve as binding sites for both Kap95p and Mex67p at the nuclear pore complex
37. Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores
38. Mex67p, a novel factor for nuclear mRNA rexport binds to both poly(A)+ RNA and nuclear pores
39. The mRNA export in C. elegans is mediated by Ce-NXF-1, an ortholog of human TAP/NXF1 and S. cerevisiae Mex67p
40. Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export
41. TAP, the human homologue of Mex67p, mediates CTE-dependent RNA export from the nucleus
42. The human TAP protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences
43. The structure of the mRNA nuclear export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain
44. A novel domain reveals details of the TAP/p15 interaction in nuclear export
45. Identification of an NTF2-related factor that binds RanGTP and regulates nuclear protein export
46. Binding of the Mex67p/Mtr2p heterodimer to FXFG, GLFG, and FG repeat nucleoporins is essential for nuclear mRNA export
47. Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export
48. Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export
49. Dbp5, a DEAD box-protein required for mRNA export, is recruited to the cytoplasmic fibrils of Nuclear Pore Complex via a conserved interaction with CAN/Nup159p
50. A perfect message: RNA Surveillance a nonsense-mediated decay
51. Pre-mRNA splicing alters mRNP composition: Evidence for stable association of proteins at exon-exon junctions
52. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
53. Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm
54. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
55. The acute myeloid leukemia-associated protein DEK forms a splicing-dependent intercation with exon-product complexes
56. REF, an evolutionarily conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export
57. Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export
58. REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus
59. Splicing is required for rapid and efficient mRNA export in metazoans
60. Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA
61. Pre-mRNA processing factors are required for nuclear export
62. The road to ribosomes. Filling potholes in the export pathway
63. Nuclear transport and transcription