The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain

EMBO Journal

Volumn 19, Issue 21, 2000, Pages 5587-5598

  Liker, E ^a   Fernandez, E ^a   Izaurralde, E ^a   Conti, E ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

Crystal structure; CTE; Nucleocytoplasmic transport; RNA export; RNP

Indexed keywords

CARRIER PROTEIN; LEUCINE; MESSENGER RNA; RIBONUCLEOPROTEIN; VIRUS RNA;

ARTICLE; CIS ISOMER; CRYSTAL STRUCTURE; CYTOPLASM; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; RETROVIRUS; RNA BINDING; RNA TRANSPORT; SPLICEOSOME;

RNA VIRUSES; SIMIAE; TYPE D RETROVIRUSES; UNIDENTIFIED RETROVIRUS;

EID: 0034331288     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.21.5587     Document Type: Article

References (45)

1. The C-terminal domain of TAP interacts with the nuclear pore complex promotes export of specific CTE-bearing RNA substrates
2. Identification of novel import and export signals of human TAP, the protein that binds to the CTE element of the type D retrovirus mRNAs
3. Analysis of the RNA-recognition motif and RS and RGG domains: Conservation in metazoan pre-mRNA splicing factors
4. TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus
5. Crystallographic and NMR system: A new software system for macromolecular structure determination
6. Conserved structures and diversity of functions in RNA-binding proteins
7. Ribbons 2.0
8. The CCP4 suite: Programs for protein crystallography
9. Retroviruses as model systems for the study of nuclear RNA export pathways
10. Maximum-likelihood heavy atom parameter refinement for multiple isomorphous replacement and multiwavelength diffraction methods
11. Recognition of polyadenylate RNA by the poly(A)-binding protein
12. Secondary structure and mutational analysis of the Mason-Pfizer monkey virus RNA constitutive transport element
13. Transport between the cell nucleus and the cytoplasm
14. TAP, the human homologue of Mex67p, mediates CTE-dependent RNA export from the nucleus
15. Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein
16. TAP/NXF1 belongs to a multigene family of putative RNA export factors with a conserved modular architecture
17. Protein structure comparison by alignment of distance matrices
18. Nuclear export of different classes of RNA is mediated by specific factors
19. Improved methods for building protein models in electron density maps and the location of errors in these models
20. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human
21. Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats
22. Proteins with leucine-rich repeats
23. Crystal structure of a mammalian poly(A) polymerase in complex with an analog of ATP
24. Nucleocytoplasmic transport: The soluble phase
25. Solvent content of protein crystals
26. Crystal structure of the RNA binding domain of the U1 small nuclear ribonucleoprotein A
27. Transport of proteins and RNAs in and out of the nucleus
28. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
29. Processing of X-ray diffraction data collected in oscillation mode
30. Crystal structure at 1.92Å resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin
31. The constitutive transport element (CTE) of Mason-Pfizer monkey virus (MPMV) accesses an RNA export pathway utilized by cellular messenger RNAs
32. Crystal structure of the spliceosomal U2B'-U2A' protein complex bound to a fragment of U2 small nuclear RNA
33. The simian retrovirus-1 constitutive transport element (CTE), unlike HIV-1 RRE utilizes factors required for cellular RNA export
34. Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores
35. Major determinants of the specificity of interaction between small nuclear ribonucleoproteins U1A and U2B' and their cognate RNAs
36. The U2B' RNP motif as a site of protein-protein interaction
37. + RNA and nuclear pores
38. Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export
39. REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export
40. Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins
41. The posttranscriptional control element of the simian retrovirus type 1 forms an extensive RNA secondary structure necessary for its function
42. Bayesian MAD phasing
43. Roles of U4 and U6 snRNAs in the assembly of splicing complexes
44. RNA recognition by RNP proteins during RNA processing