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Cyster J.G., Goodnow C.C. Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. Immunity. 2:1995;13-24.
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(1995)
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Cyster, J.G.1
Goodnow, C.C.2
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49
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Polygenic autoimmune traits: Lyn, CD22 and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection
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Cornall R.J., Cyster J.G., Hibbs M.L., Dunn A.R., Otipoby K.L., Clark E.A., Goodnow C.C. Polygenic autoimmune traits: Lyn, CD22 and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Immunity. 8:1998;497-508.
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Cornall, R.J.1
Cyster, J.G.2
Hibbs, M.L.3
Dunn, A.R.4
Otipoby, K.L.5
Clark, E.A.6
Goodnow, C.C.7
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50
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Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection
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high stage B cells are prone to apoptosis, the authors propose the developmental model to reconcile deletion and editing models.
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high stage B cells are prone to apoptosis, the authors propose the developmental model to reconcile deletion and editing models.
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Cell
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Melamed, D.1
Benschop, R.J.2
Cambier, J.C.3
Nemazee, D.4
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51
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0033103016
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Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter
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dull bone marrow stroma cells protect immature B cells from BCR-mediated apoptosis, the authors propose the model that - as long as immature B cells contact with specialized microenvironments - cells are allowed to undergo receptor editing because of survival signals from these microenvironments.
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dull bone marrow stroma cells protect immature B cells from BCR-mediated apoptosis, the authors propose the model that - as long as immature B cells contact with specialized microenvironments - cells are allowed to undergo receptor editing because of survival signals from these microenvironments.
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Immunity
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Sandel, P.C.1
Monroe, J.G.2
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52
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0030694311
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Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells
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Lang J., Arnold B., Hammerling G., Harris A.W., Korsmeyer S., Russell D., Strasser A., Nemazee D. Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells. J Exp Med. 186:1997;1513-1522.
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Lang, J.1
Arnold, B.2
Hammerling, G.3
Harris, A.W.4
Korsmeyer, S.5
Russell, D.6
Strasser, A.7
Nemazee, D.8
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53
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0032127299
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Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing
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Fang W., Weintraub B.C., Dunlap B., Garside P., Pape K.A., Jenkins M.K., Goodnow C.C., Mueller D.L., Behrens T.W. Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing. Immunity. 9:1998;35-45.
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(1998)
Immunity
, vol.9
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Fang, W.1
Weintraub, B.C.2
Dunlap, B.3
Garside, P.4
Pape, K.A.5
Jenkins, M.K.6
Goodnow, C.C.7
Mueller, D.L.8
Behrens, T.W.9
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