The prion folding problem

Current Opinion in Structural Biology

Volumn 7, Issue 1, 1997, Pages 53-59

  Harrison, Paul M ^a   Bamborough, Paul ^a   Daggett, Valerie ^b   Prusiner, Stanley B ^a   Cohen, Fred E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

AMINO TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; NERVE DEGENERATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRION DISEASE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE; REVIEW; SIMULATION; STOP CODON; TRANSGENE;

EID: 0031043927     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(97)80007-3     Document Type: Article

References (51)

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51. +] non-mendelian inheritance phenomenon in yeast is a conformational prion condition reliant on conformational change in the endogenous yeast protein Sup35. For effective PSI propagation, intermediate concentrations of the yeast molecular chaperone Hsp 104 are required.