메뉴 건너뛰기




Volumn 4, Issue 12, 1999, Pages 743-756

Triggering of neuronal cell death by accumulation of activated Sek1 on nuclear polyglutamine aggregations in PML bodies

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR PROTEIN; POLYGLUTAMINE; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN C JUN; PROTEIN SEK1; UNCLASSIFIED DRUG;

EID: 6744248868     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.1999.00294.x     Document Type: Article
Times cited : (63)

References (42)
  • 1
    • 0033030565 scopus 로고    scopus 로고
    • Evidence for proteasome involvement in polyglutamine disease: Localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro
    • Chai, Y., Koppenhafer, S.L., Shoesmith, S.J., et al. (1999) Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro. Hum. Molec. Genet. 8, 673-682.
    • (1999) Hum. Molec. Genet. , vol.8 , pp. 673-682
    • Chai, Y.1    Koppenhafer, S.L.2    Shoesmith, S.J.3
  • 2
    • 7144253143 scopus 로고    scopus 로고
    • Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture
    • Cooper, J.K., Schilling, G., Peters, M.F., et al. (1998) Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture. Hum. Mol. Genet. 7, 783-790.
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 783-790
    • Cooper, J.K.1    Schilling, G.2    Peters, M.F.3
  • 3
    • 18544410106 scopus 로고    scopus 로고
    • Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
    • Davies, S.W., Turmaine, M., Cozens, B.A., et al. (1997) Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 90, 537-548.
    • (1997) Cell , vol.90 , pp. 537-548
    • Davies, S.W.1    Turmaine, M.2    Cozens, B.A.3
  • 4
    • 0030752709 scopus 로고    scopus 로고
    • Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
    • DiFiglia, M., Sapp, E., Chase, K.O., et al. (1997) Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277, 1990-1993.
    • (1997) Science , vol.277 , pp. 1990-1993
    • DiFiglia, M.1    Sapp, E.2    Chase, K.O.3
  • 5
    • 0028179010 scopus 로고
    • A novel macromolecular structure is a target of the promyelocyteretinoic acid receptor oncoprotein
    • Dyck, J.A., Maul, G.G., Miller, W.H. Jr, et al. (1994) A novel macromolecular structure is a target of the promyelocyteretinoic acid receptor oncoprotein. Cell 76, 333-343.
    • (1994) Cell , vol.76 , pp. 333-343
    • Dyck, J.A.1    Maul, G.G.2    Miller Jr., W.H.3
  • 6
    • 0029786994 scopus 로고    scopus 로고
    • 2-terminal, leucine-rich short amino acid sequence, which acts as a nuclear export signal
    • 2-terminal, leucine-rich short amino acid sequence, which acts as a nuclear export signal. J. Biol. Chem. 271, 20024-20028.
    • (1996) J. Biol. Chem. , vol.271 , pp. 20024-20028
    • Fukuda, M.1    Gotoh, I.2    Gotoh, Y.3    Nishida, E.4
  • 7
    • 0027994002 scopus 로고
    • An osmosensing signal transduction pathway in mammalian cells
    • Galcheva-Gargova, Z., Dérijard, B., Wu, I.-H. & Davis, R.J. (1994) An osmosensing signal transduction pathway in mammalian cells. Science 265, 806-808.
    • (1994) Science , vol.265 , pp. 806-808
    • Galcheva-Gargova, Z.1    Dérijard, B.2    Wu, I.-H.3    Davis, R.J.4
  • 8
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen, M. & Bujard, H. (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89, 5547-5551.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 9
    • 14444281569 scopus 로고    scopus 로고
    • Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
    • Ichijo, H., Nishida, E., Irie, K., et al. (1997) Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275, 90-94.
    • (1997) Science , vol.275 , pp. 90-94
    • Ichijo, H.1    Nishida, E.2    Irie, K.3
  • 10
    • 17344362229 scopus 로고    scopus 로고
    • Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch
    • Igarashi, S., Koide, R., Shimohata, T., et al. (1998) Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch. Nat. Genet. 18, 111-117.
    • (1998) Nat. Genet. , vol.18 , pp. 111-117
    • Igarashi, S.1    Koide, R.2    Shimohata, T.3
  • 11
    • 0030058208 scopus 로고    scopus 로고
    • Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo
    • Ikeda, H., Yamaguchi, M., Sugai, S., et al. (1996) Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo. Nat. Genet. 13, 196-202.
    • (1996) Nat. Genet. , vol.13 , pp. 196-202
    • Ikeda, H.1    Yamaguchi, M.2    Sugai, S.3
  • 12
    • 0032054723 scopus 로고    scopus 로고
    • Signal transduction by the c-Jun N-terminal kinase (JNK) - From inflammation to development
    • Ip, Y.T. & Davis, R.J. (1998) Signal transduction by the c-Jun N-terminal kinase (JNK) - from inflammation to development. Curr. Opin. Cell. Biol. 10, 205-219.
    • (1998) Curr. Opin. Cell. Biol. , vol.10 , pp. 205-219
    • Ip, Y.T.1    Davis, R.J.2
  • 13
    • 0032168160 scopus 로고    scopus 로고
    • Polyglutamine-expanded in human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons
    • Jackson, G.R., Salecker, I., Dong, X., et al. (1998) Polyglutamine-expanded in human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons. Neuron 21, 633-642.
    • (1998) Neuron , vol.21 , pp. 633-642
    • Jackson, G.R.1    Salecker, I.2    Dong, X.3
  • 14
    • 0025780876 scopus 로고
    • Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML
    • Kakizuka, A., Miller, W.H. Jr, Umesono, K., et al. (1991) Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML. Cell 66, 663-674.
    • (1991) Cell , vol.66 , pp. 663-674
    • Kakizuka, A.1    Miller Jr., W.H.2    Umesono, K.3
  • 15
    • 0030747442 scopus 로고    scopus 로고
    • Degenerative ataxias: Genetics, pathogenesis and animal models
    • Kakizuka, A. (1997) Degenerative ataxias: genetics, pathogenesis and animal models. Curr. Opin. Neurol. 10, 285-290.
    • (1997) Curr. Opin. Neurol. , vol.10 , pp. 285-290
    • Kakizuka, A.1
  • 16
    • 0031761706 scopus 로고    scopus 로고
    • Protein precipitation: A common etiology in neurodegenerative disorders?
    • Kakizuka, A. (1998) Protein precipitation: a common etiology in neurodegenerative disorders? Trend. Genet. 14, 396-402.
    • (1998) Trend. Genet. , vol.14 , pp. 396-402
    • Kakizuka, A.1
  • 17
    • 0028143527 scopus 로고
    • CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1
    • Kawaguchi, Y., Okamoto, T., Taniwaki, M., et al. (1994) CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1. Nat. Genet. 8, 221-228.
    • (1994) Nat. Genet. , vol.8 , pp. 221-228
    • Kawaguchi, Y.1    Okamoto, T.2    Taniwaki, M.3
  • 18
    • 0032475941 scopus 로고    scopus 로고
    • Ataxin-1 nuclear localization and aggregation: Role in polyglutamine-induced disease in SCA1 transgenic mice
    • Klement, I.A., Skinner, P.J., Kaytor, M.D., et al. (1998) Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice. Cell 95, 41-53.
    • (1998) Cell , vol.95 , pp. 41-53
    • Klement, I.A.1    Skinner, P.J.2    Kaytor, M.D.3
  • 19
    • 0027989808 scopus 로고
    • Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis
    • Koopman, G., Reutelingsperger, C.P.M., Kuijten, G.A.M., et al. (1994) Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84, 1415-1420.
    • (1994) Blood , vol.84 , pp. 1415-1420
    • Koopman, G.1    Reutelingsperger, C.P.M.2    Kuijten, G.A.M.3
  • 20
    • 0031945025 scopus 로고    scopus 로고
    • Aggregation of N-terminal huntingtin is dependent on the length of its glutamine repeats
    • Li, S.-H. & Li, X.-J. (1998) Aggregation of N-terminal huntingtin is dependent on the length of its glutamine repeats. Hum. Mol. Genet. 7, 777-782.
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 777-782
    • Li, S.-H.1    Li, X.-J.2
  • 21
    • 15144342225 scopus 로고    scopus 로고
    • Nuclear inclusions of the androgen receptor protein in spinal and bulb muscular atrophy
    • Li, M., Miwa, S., Kobayashi, Y., et al. (1998) Nuclear inclusions of the androgen receptor protein in spinal and bulb muscular atrophy. Ann. Neural. 44, 249-254.
    • (1998) Ann. Neural. , vol.44 , pp. 249-254
    • Li, M.1    Miwa, S.2    Kobayashi, Y.3
  • 22
    • 0001388128 scopus 로고    scopus 로고
    • Expression of polyglutamine-expanded huntingtin activates the SEK1-JNK pathway and induces apoptosis in a hippocampal neuronal cell line
    • Liu, Y.F. (1998) Expression of polyglutamine-expanded huntingtin activates the SEK1-JNK pathway and induces apoptosis in a hippocampal neuronal cell line. J. Biol. Chem. 273, 28873-28877.
    • (1998) J. Biol. Chem. , vol.273 , pp. 28873-28877
    • Liu, Y.F.1
  • 23
    • 0031680014 scopus 로고    scopus 로고
    • A cellular model that recapitulates major pathogenic steps of Huntington's disease
    • Lunkes, A. & Mandel, J.L. (1998) A cellular model that recapitulates major pathogenic steps of Huntington's disease. Hum. Molec. Genet. 7, 1355-1361.
    • (1998) Hum. Molec. Genet. , vol.7 , pp. 1355-1361
    • Lunkes, A.1    Mandel, J.L.2
  • 24
    • 0033179146 scopus 로고    scopus 로고
    • Nuclear bodies: Multifaceted subdomains of the interchromatin space
    • Matera, A.G. (1999) Nuclear bodies: multifaceted subdomains of the interchromatin space. Trend. Cell Biol. 9, 302-309.
    • (1999) Trend. Cell Biol. , vol.9 , pp. 302-309
    • Matera, A.G.1
  • 25
    • 17344363559 scopus 로고    scopus 로고
    • Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates
    • Martindale, D., Hackam, A., Wieczorek, A., et al. (1998) Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates. Nat. Genet. 18, 150-154.
    • (1998) Nat. Genet. , vol.18 , pp. 150-154
    • Martindale, D.1    Hackam, A.2    Wieczorek, A.3
  • 27
    • 0031948607 scopus 로고    scopus 로고
    • Cleavage, aggregation and toxicity of the expanded androgen receptor in spinal and bulbar muscular atrophy
    • Merry, D.E., Kobayashi, Y., Bailey, C.K., Taye, A.A. & Fischbeck, K.H. (1998) Cleavage, aggregation and toxicity of the expanded androgen receptor in spinal and bulbar muscular atrophy. Hum. Mol. Genet. 7, 693-701.
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 693-701
    • Merry, D.E.1    Kobayashi, Y.2    Bailey, C.K.3    Taye, A.A.4    Fischbeck, K.H.5
  • 28
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann, T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 29
    • 0008559467 scopus 로고    scopus 로고
    • Genetic and molecular studies of Machado-Joseph Disease
    • (eds R.D. Wells & S.T.Warren), San Diego, CA: Academic Press
    • Nakamoto, M., Ikeda, H. & Kakizuka, A. (1998) Genetic and molecular studies of Machado-Joseph Disease. In: Genetic Instabilities and Hereditary Neurological Diseases (eds R.D. Wells & S.T.Warren), pp. 283-297. San Diego, CA: Academic Press.
    • (1998) Genetic Instabilities and Hereditary Neurological Diseases , pp. 283-297
    • Nakamoto, M.1    Ikeda, H.2    Kakizuka, A.3
  • 30
    • 0031469707 scopus 로고    scopus 로고
    • Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse
    • Ordway, J.M., Tallaksen-Greene, S., Gutekunst, C.-A., et al. (1997) Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse. Cell 91, 753-763.
    • (1997) Cell , vol.91 , pp. 753-763
    • Ordway, J.M.1    Tallaksen-Greene, S.2    Gutekunst, C.-A.3
  • 31
    • 0030850412 scopus 로고    scopus 로고
    • Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3
    • Paulson, H.L., Perez, M.K., Trottier, Y., et al. (1997) Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3. Neuron 19, 333-344.
    • (1997) Neuron , vol.19 , pp. 333-344
    • Paulson, H.L.1    Perez, M.K.2    Trottier, Y.3
  • 32
    • 0031794632 scopus 로고    scopus 로고
    • PML induces a novel caspase-independent death process
    • Quignon, F., De Bels, F., Koken, M., et al. (1998) PML induces a novel caspase-independent death process. Nature Genet. 20, 259-265.
    • (1998) Nature Genet. , vol.20 , pp. 259-265
    • Quignon, F.1    De Bels, F.2    Koken, M.3
  • 33
    • 0032080283 scopus 로고    scopus 로고
    • Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
    • Saitoh, M., Nishitoh, H., Fujii, M., et al. (1998) Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J. 17, 2596-2606.
    • (1998) EMBO J. , vol.17 , pp. 2596-2606
    • Saitoh, M.1    Nishitoh, H.2    Fujii, M.3
  • 34
    • 0028558986 scopus 로고
    • Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-jun
    • Sánchez, I., Hughes, R.T., Mayer, B.J., et al. (1994) Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-jun. Nature 372, 794-798.
    • (1994) Nature , vol.372 , pp. 794-798
    • Sánchez, I.1    Hughes, R.T.2    Mayer, B.J.3
  • 35
    • 0032475931 scopus 로고    scopus 로고
    • Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions
    • Saudou, F., Finkbeiner, S., Devys, D. & Greenberg, M.E. (1998) Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell 95, 55-66.
    • (1998) Cell , vol.95 , pp. 55-66
    • Saudou, F.1    Finkbeiner, S.2    Devys, D.3    Greenberg, M.E.4
  • 36
    • 7344234800 scopus 로고    scopus 로고
    • An isoform of ataxin-3 accumulates in the nucleus of neuronal cells in affected brain regions of SCA3 patients
    • Schmidt, T., Landwehrmeyer, G.B., Schmitt, I., et al. (1998) An isoform of ataxin-3 accumulates in the nucleus of neuronal cells in affected brain regions of SCA3 patients. Brain Pathol. 8, 669-679.
    • (1998) Brain Pathol. , vol.8 , pp. 669-679
    • Schmidt, T.1    Landwehrmeyer, G.B.2    Schmitt, I.3
  • 37
    • 0030957325 scopus 로고    scopus 로고
    • Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons
    • Schwarzschild, M.A., Cole, R.L. & Hyman, S.E. (1997) Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons. J. Neurosci. 17, 3455-3466.
    • (1997) J. Neurosci. , vol.17 , pp. 3455-3466
    • Schwarzschild, M.A.1    Cole, R.L.2    Hyman, S.E.3
  • 38
    • 0030666001 scopus 로고    scopus 로고
    • Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures
    • Skinner, P.J., Koshy, B.T., Cummings, C.J., et al. (1997) Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures. Nature 389, 971-974.
    • (1997) Nature , vol.389 , pp. 971-974
    • Skinner, P.J.1    Koshy, B.T.2    Cummings, C.J.3
  • 39
    • 0031791875 scopus 로고    scopus 로고
    • Pml is essential for multiple apoptotic pathways
    • Wang, Z.-G., Ruggero, D., Ronchetti, S., et al. (1998) Pml is essential for multiple apoptotic pathways. Nat. Genet. 20, 266-272.
    • (1998) Nat. Genet. , vol.20 , pp. 266-272
    • Wang, Z.-G.1    Ruggero, D.2    Ronchetti, S.3
  • 40
    • 18544392423 scopus 로고    scopus 로고
    • Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila
    • Warrick, J.M., Paulson, H.L., Gray-Board, G.L., et al. (1998) Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila. Cell 93, 939-949.
    • (1998) Cell , vol.93 , pp. 939-949
    • Warrick, J.M.1    Paulson, H.L.2    Gray-Board, G.L.3
  • 41
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia, Z., Dickens, M., Raingeaud, J., Davis, R.J. & Greenberg, M.E. (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331.
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5
  • 42
    • 0030780804 scopus 로고    scopus 로고
    • Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
    • Yang, D.D., Kuan, C.Y., Whitmarsh, A.J., et al. (1997) Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 389, 865-870.
    • (1997) Nature , vol.389 , pp. 865-870
    • Yang, D.D.1    Kuan, C.Y.2    Whitmarsh, A.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.