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Transmembrane-type guanylyl cyclases may also contribute to chemosensation. Guanylyl cyclase-D is expressed in a restricted subset of rodent OSNs that project to necklace glomeruli [H. J. Fülle et al., Proc. Natl. Acad. Sci. U.S.A. 92, 3571 (1995); D. M. Juilfs et al., ibid. 94, 3388 (1997)]. The genome of C. elegans has 29 guanylyl cydases, some of which are expressed in chemosensory neurons ( S. Yu, L. Avery, E. Baude, D. L. Garbers, ibid., p. 3384). Their roles and ligands are not known.
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Transmembrane-type guanylyl cyclases may also contribute to chemosensation. Guanylyl cyclase-D is expressed in a restricted subset of rodent OSNs that project to necklace glomeruli [H. J. Fülle et al., Proc. Natl. Acad. Sci. U.S.A. 92, 3571 (1995); D. M. Juilfs et al., ibid. 94, 3388 (1997)]. The genome of C. elegans has 29 guanylyl cydases, some of which are expressed in chemosensory neurons ( S. Yu, L. Avery, E. Baude, D. L. Garbers, ibid., p. 3384). Their roles and ligands are not known.
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note
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I thank L. Buck and R. Axel for initiating this journey, and R. Axel for postdoctoral guidance and continuous support. I thank the members of my laboratory, in particular T. Bozza and C. Zheng, and S. Firestein for critically reviewing the manuscript. I benefited from incisive comments by T. Perry and L. Stryer. I thank C. Bargmann, J. Carlson, P. Sengupta, E. Troemel, and L. Vosshall for providing useful information. Supported by NIH and the Human Frontier Science Program. I am an Alfred P. Sloan, Basil O'Connor, Guggenheim, Irma T. Hirschl, Klingenstein, McKnight, Rita Allen, and Searle Scholar or Fellow.
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