New 4-point pharmacophore method for molecular similarity and diversity applications: Overview of the method and applications, including a novel approach to the design of combinatorial libraries containing privileged substructures

Journal of Medicinal Chemistry

Volumn 42, Issue 17, 1999, Pages 3251-3264

  Mason, Jonathan S ^c   Morize, Isabelle ^a   Menard, Paul R ^a   Cheney, Daniel L ^c   Hulme, Christopher ^b   Labaudiniere, Richard F ^b  

^a Rhône Poulenc Rorer ^*  (United States)

^b Lead Discovery Department   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEVAZEPIDE; LOSARTAN; VALSARTAN;

ARTICLE; DATA BASE; DRUG ACTIVITY; DRUG CONFORMATION; DRUG DESIGN; DRUG STRUCTURE; ENZYME ACTIVE SITE; HYDROGEN BOND; PHARMACOPHORE; SIGNAL NOISE RATIO;

BINDING SITES; DATABASES, FACTUAL; DRUG DESIGN; LIGANDS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033606988     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9806998     Document Type: Article

References (29)

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29. 3CN to 100% over 5 min; HPLC was interfaced with APCI techniques.