Adenosine: A partial agonist of the growth hormone secretagogue receptor

Biochemical and Biophysical Research Communications

Volumn 276, Issue 3, 2000, Pages 1306-1313

  Smith, Roy G ^a,b   Griffin, Patrick R ^b   Xu, Yuan ^a   Smith, Alexander G A ^a   Liu, Ken ^b   Calacay, Jimmy ^b   Feighner, Scott D ^b   Pong, C S ^b   Leong, Denis ^b   Pomés, Anna ^b   Cheng, Kang ^b   Van Der Ploeg, Lex H T ^b   Howard, Andrew D ^b   Schaeffer, James ^b   Leonard, Reid J ^b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; AEQUORIN; DOPAMINE; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; HORMONE RECEPTOR AFFECTING AGENT; HORMONE RECEPTOR BLOCKING AGENT; IBUTAMOREN;

ANIMAL TISSUE; ARTICLE; BINDING SITE; DOPAMINE RELEASE; GROWTH HORMONE RELEASE; HORMONAL REGULATION; HUMAN; HUMAN CELL; HYPOTHALAMUS; LIGAND BINDING; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PULSATILE HORMONE RELEASE;

EID: 0034609956     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.3610     Document Type: Article

References (38)

1. Peptidomimetic regulation of growth hormone (GH) secretion
2. Growth hormone-releasing hormone: Synthesis and signaling
3. Somatostatin receptor subtype-2 knockout mice are refractory to growth hormone negative feedback on arcuate neurons
4. Modulation of pulsatile GH release through a novel receptor in hypothalamus and pituitary gland
5. A receptor in pituitary and hypothalamus that functions in growth hormone release
6. Identification of a new G-protein-linked receptor for growth hormone secretagogues
7. Ligand activation domain of human orphan growth hormone secretagogue receptor (GHS-R) conserved from Pufferfish to humans
8. Expression of GH secretagogue-receptors by GH-releasing hormone neurons in the mediobasal hypothalamus
9. 24-Hour growth hormone (GH)-releasing peptide (GHRP) infusion enhances pulsatile GH secretion and specifically attenuates the response to a subsequent GHRP-6 bolus
10. Enhancement of pulsatile growth hormone secretion by continuous infusion of a growth hormone-releasing peptide mimetic, L-692,429, in older adults - A clinical research center study
11. Stimulation of the growth hormone (GH)-insulin-like growth factor-I axis by daily oral administration of a GH secretagogue (MK-0677) in healthy elderly subjects
12. A new orphan receptor involved in pulsatile growth hormone release
13. Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man
14. Ghrelin is a growth-hormone-releasing acylated peptide from stomach
15. Adenosine is an agonist of the growth hormone secretagogue receptor
16. Aequorin-expressing mammalian cell lines used to report Ca2+ mobilization
17. An automated aequorin luminescence-based functional calcium assay for G-protein-coupled receptors
18. L-692,429-stimulated rat growth hormone release by a weak substance-P antagonist, L-756
19. A nonpeptidyl growth hormone secretagogue
20. Structural requirements for the activation of the human growth hormone secretagogue receptor by peptide and non-peptide secretagogues
21. Development of a high specific activity sulfur-35-labeled sulfonamide radioligand that allowed the identification of a new growth hormone secretagogue receptor
22. A novel hypothalamic hormone measured in hypophyseal portal plasma drives rapid bursts of GH secretion
23. Receptor for motilin identified in the human gastrointestinal system
24. Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3
25. Nomenclature and classification of purinoreceptors
26. Desensitization studies using perifused rat pituitary cells show that growth hormone releasing hormone and His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 stimulates growth hormone release through distinct receptor sites
27. Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia
28. Evidence for a role of protein kinase-C in His-D-Trp-Ala-Trp-D-Phe-Lys-NH2-induced growth hormone release from rat primary pituitary cells
29. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues
30. 2+-sensitive adenylate
31. Pharmacology of adenosine A(2A) receptors
32. L-dopa restores amplitude of growth hormone pulses in old male rats to that observed in young male rats
33. Expression of tyrosine hydroxylase in cultured brain cells: Stimulation with an extractable pituitary cytotropic factor
34. Tyrosine hydroxylase expression in hypothalamic cells: Analysis of the roles of adenosine 3',5'-monophosphate- and Ca2+/calmodulin-dependent protein kinases in the action of pituitary cytotropic factor
35. Purification and identification of pituitary cytotropic factor
36. L-dopa stimulates release of hypothalamic growth hormone-releasing hormone in humans
37. Growth hormone (GH)-releasing hormone secretion is stimulated by a new GH-releasing hexapeptide in sheep
38. Growth hormone-releasing hormone and somastatin concentrations in the hypophysial portal blood of conscious sheep during the infusion of growth hormone-releasing peptide-6