Lymphoid neogenesis: De novo formation of lymphoid tissue in chronic inflammation through expression of homing chemokines

Journal of Leukocyte Biology

Volumn 69, Issue 3, 2001, Pages 331-339

  Hjelmström, Peter ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Autoimmune diseases; CCL21 CCR7; CXCL13 CXCR5; Germinal centers; High endothelial venules; Lymphoma

Indexed keywords

CHEMOKINE; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR;

ANTIGEN RECOGNITION; AUTOIMMUNE DISEASE; CHRONIC INFLAMMATION; GASTRITIS; GERMINAL CENTER; HASHIMOTO DISEASE; HELICOBACTER PYLORI; LYMPHOID TISSUE; LYMPHOMA; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; SJOEGREN SYNDROME;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CHEMOKINES; HUMANS; INFLAMMATION; LYMPHOID TISSUE; LYMPHOMA;

HELICOBACTER PYLORI;

EID: 0035109174     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (154)

1. Physiological and molecular mechanisms of lymphocyte homing
2. Chronic inflammation caused by lymphotoxin is lymphoid neogenesis
3. Development and maturation of secondary lymphoid tissues
4. Mediators of inflammation
5. Lymphoid neo-organogenesis: Lymphotoxin's role in inflammation and development
6. A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immonodeficiency in mice
7. Alymphoplasia is caused by a point mutation in the mouse gene encoding NF-kappaB-inducing kinase
8. Alymphoplasia (aly)-type nuclear factor kappaB-inducing kinase (NIK) causes defects in secondary lymphoid tissue chemokine receptor signaling and homing of peritoneal cells to the gut-associated lymphatic tissue system
9. Secondary lymphoid-tissue chemokine (SLC) stimulates integrin α4β7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow
10. Analysis of expression of lymphocyte homing-related adhesion molecules in ALY mice deficient in lymph nodes and Peyer's patches
11. Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue
12. Distinct activities of p52/NF-kappa B required for proper secondary lymphoid organ microarchitecture: Functions enhanced by Bcl-3
13. Downstream activation of a TATA-less promoter by Oct-2. Bobl, and NF-kappaB directs expression of the homing receptor BLR1 to mature B cells
14. Phosphorylation of Oct-2 at sites located in the POU domain induces differential down-regulation of Oct-2 DNA-binding ability
15. Chemokines and cell migration in secondary lymphoid organs
16. Chemokine receptors in lymphoid organ homeostasis
17. The role of chemokines in regulating cell migration during humoral immune responses
18. Chemokines in tissue-specific and microenvironment-specific lymphocyte homing
19. The role of chemokine receptors in primary, effector, and memory immune responses
20. Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen
21. Gene profiling approach in the analysis of lymphotoxin and TNF deficiencies
22. Lymphoid tissue homing chemokines are expressed in chronic inflammation
23. BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis
24. Ectopic expression of the chemokine TCA4/SLC is sufficient to trigger lymphoid neogenesis
25. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1
26. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
27. In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines
28. Activation-dependent modulation of B lymphocyte migration to chemokines
29. Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma
30. Selective expression of the murine homologue of the G-protein-coupled receptor BLRI in B cell differentiation, B cell neoplasia and defined areas of the cerebellum
31. Expression of the G-protein-coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells
32. CD4 T cell cytokine differentiation: The B cell activation molecule. OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1
33. Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells
34. Developmental switches in chemokine response profiles during B cell differentiation and maturation
35. A chemokine-driven positive feedback loop organizes lymphoid fullicles
36. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
37. + cells that can differentiate to APC. NK cells, and follicular cells but not T or B cells
38. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2
39. IL-7 receptor alpha+ CD3(+) cells in the embryonic intestine induces the organizing center of Peyer's patches
40. Follicular stromal cells and lymphocyte homing to follicles
41. Requirement for RORγ in thymocyte survival and lymphoid organ development
42. Retinoid-related orphan receptor gamma (RORγ) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis
43. CXCR5-deficient mice develop functional germinal centers in the splenic T cell zone
44. Functional effects of TNF and lymphotoxin α1β2 on FDC-like cells
45. Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers
46. Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue
47. Inflammation, a prototype for organogenesis of the lymphopoietic/hematopoietic system
48. Identification and characterization of a novel beta chemokine containing six conserved cysteines
49. Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension
50. Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13
51. Identification of a new mouse β-chemokine, thymus-derived chemotactic agent 4, with activity on T lymphocytes and mesangial cells
52. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes
53. 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7
54. The chemokine SLC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7
55. Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7
56. Species specificity of the CC chemokine 6Ckine signaling through the CXC chemokine receptor CXCR3: Human 6Ckine is not a ligand for the human or mouse CXCR3 receptors
57. The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3
58. Identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK
59. Cloning of human and mouse EBll, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2
60. Expression of the chemokine receptor BLR2/EBll is specifically transactivated by Epstein-Barr virus nuclear antigen 2
61. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites
62. A lymphocyte-specific CC chemokine, secondary lymphoid tissue chemokine (SLC), is a highly efficient chemoattractant for B cells and activated T cells
63. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
64. Differential regulation of chemokine receptors during dendritic cell maturation: A model for their trafficking properties
65. EBll/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation
66. EBll-ligand chemokine (ELC) attracts a broad spectrum of lymphocytes: Activated T cells strongly up-regulate CCR7 and efficiently migrate toward ELC
67. Developmental switches in chemokine responses during T cell maturation
68. Secondary lymphoid-tissue chemokine (SLC) is chemotactic for mature dendritic cells
69. The CC chemokine receptor-7 ligands 6Ckine and macrophage inflammatory protein-3 beta are potent chemoattractants for in vitro- and in vivo-derived dendritic cells
70. Distinct patterns and kinetics of chemokine production regulate dendritic cell function
71. Chemotactic response toward chemokines and its regulation by transforming growth factor-betal of murine bone marrow hematopoietic progenitor cell-derived different subset of dendritic cells
72. Secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes
73. Differential responsiveness to constitutive versus inducible chemokines of immature and mature mouse dendritic cells
74. Maturation amid trafficking of monocyte-derived dendritic cells in monkeys: Implications for dendritic cell-based vaccines
75. CC chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: Critical role in migration from the tumor site to draining lymph nodes
76. Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines, macrophage inflammatory protein (MIP)-3α, MIP-3β, and secondary lymphoid organ chemokine
77. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
78. + human memory T cells
79. CCR7 ligands, SLC/6Ckine/Exodus2/TCA4 and CKβ-11/MIP-3β/ELC, are chemoattractants for CD56(+)CD16(-) NK cells and late stage lymphoid progenitors
80. The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo
81. The CC chemokine thymus-derived chemotactic agent 4 ITCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules
82. The role of chemokines in the microenvironmental control of T versus B cell arrest in Peyer's patch high endothelial venules
83. Hierarchy of chemokine receptor and TCR signals regulating T cell migration and proliferation
84. Increased chemokine receptor CCR7/EBll expression enhances the infiltration of lymphoid organs by adult T-cell leukemia cells
85. Angiogenesis and inflammation in ductal carcinoma in situ of the breast
86. Secondary lymphoid tissue chemokine mediates T cell-dependent antitumor responses in vivo
87. Antitumor effects of the mouse chemokine 6Ckine/SLC through angiostatic and immunological mechanisms
88. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
89. Inhibition of functional T cell priming and contact hypersensitivity responses by treatment with anti-secondary lymphoid chemokine antibody during hapten sensitization
90. A novel mutant gene involved in T-lymphocyte-specific homing into peripheral lymphoid organs on mouse chromosome 4
91. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization
92. The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes
93. BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma
94. Expression and cellular localization of the CC chemokines PARC and ELC in human atherosclerotic plaques
95. Organization of the invading lymphoid tissue in human lymphoid thyroiditis
96. Immunohistological findings in Hashimoto's thyroiditis, focal lymphocytic thyroiditis and thyroiditis de Quervain
97. High endothelial venules present in lymphoid cell accumulations in thyroids affected by autoimmune disease: A study in men and BB rats of functional activity and development
98. Postcapillary venules of the lymph node type in the thymus in myasthenia
99. Thymic B cells from myasthenia gravis patients are activated B cells: Phenotypic and functional analysis
100. Expression of CD23 in germinal center of thymus from myasthenia gravis patients
101. Failure to down-regulate Bcl-2 protein in thymic germinal center B cells in myasthenia gravis
102. Practice parameter: Thymectomy for autoimmune myasthenia gravis (an evidence-based review): Report of the quality standards subcommittee of the American Academy of Neurology
103. Multiple slcerosis: Presence of lymphatic capillaries and lymphoid tissue in the brain and spinal cord
104. Vascular endothelium and lymphocyte adhesion molecules in minor salivary glands of patients with Sjogren's syndrome
105. Characterisation of follicular dendritic cells in labial salivary glands of patients with primary Sjogren syndrome: Comparison with tonsillar lymphoid follicles
106. CD4 cytotoxic and dendritic cells in the immunopathologie lesion of Sjogren's syndrome
107. Detection of clonally expanded salivary gland lymphocytes in Sjögren's syndrome
108. Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease. The salivary glands of patients with Sjogren's syndrome
109. Lymphoid proliferations of the salivary glands
110. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
111. Heberden Oration 1964: Some immunological aspects of the connective tissue diseases
112. Characteristics of mononuclear cell populations in chronically inflammed synovial membranes
113. Changes in vascular endothelium related to lymphocyte collections in diseased synovia
114. Immunohistologic characterization of synovial membrane lymphocytes in rheumatoid arthritis
115. Electron microscopic study of rheumatoid synovial vasculature: Intimate relationship between tall endothelium and lymphoid aggregation
116. Dendritic cells and high endothelial venules in the rheumatoid synovial membrane
117. A case of germinal center formation by CD45RO T and CD20 B lymphocytes in rheumatoid arthritic subchondral bone: Proposal for a twocompartment model of immune-mediated disease with implications for immunotherapeutic strategies
118. The identification of germinal centres and follicular dendritic cell networks in rheumatoid synovial tissue
119. + T cells in the formation of germinal centers in rheumatoid synovitis
120. Fibroblast-like synoviocytes from rheumatoid arthritis patients have intrinsic properties of follicular dendritic cells
121. Histopathology and molecular pathology of synovial B-lymphocytes in rheumatoid arthritis
122. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis
123. Plasma cell development in synovial germinal centers in patients with rheumatoid and reactive arthritis
124. Divergent T-cell cytokine patterns in inflammatory arthritis
125. Tissue cytokine patterns distinguish variants of rheumatoid synovitis
126. Heterogeneity of rheumatoid arthritis: From phenotypes to genotypes
127. The intraportal lymphoid nodule and its environment in chronic active hepatitis C: An immunohistochemical study
128. Focal lymphocytic aggregates in chronic hepatitis C: Occurence, immunohistochemical characterization, and relation to markers of autoimmunity
129. Functional B-cell response in intrahepatic lymphoid follicles in chronic hepatitis C
130. Expression of the mucosal vasular addressin, MAdCAM-1, in inflammatory liver disease
131. Spirochetal antigens and lymphoid cell surface markers in Lyme synovitis. Comparison with rheumatoid synovium and tonsillar lymphoid tissue
132. Lymphoid follicles in antral mucosa: Immune response to Campylobacter pylori?
133. Prevalence of lymphoid follicles and aggregates of Helicobacter pylori gastritis in antral and body mucosa
134. The significance of lymphoid follicles in the interpretation of gastric biopsy specimens
135. Helicobacter pylori infection and gastric lymphoma
136. Expression of lymphocyte homing receptors and vascular addressins in low-grade gastric B-cell lymphomas of mucosa-associated lymphoid tissue
137. The biology of low grade MALT lymphoma
138. Cancer risk in patients with chronic lymphocytic thyroiditis
139. Primary B cell lymphoma of the thyroid and its relationship to Hashimoto's thyroiditis
140. Disease activity and risk of lymphoma in patients with rheumatoid arthritis: Nested case-control study
141. Increased risk of lymphoma in sicca syndrome
142. Primary B-cell lymphoma of salivary glands and its relationship to myoepithelial sialadenitis
143. Coeliac disease and malignancy
144. Lymphoma of the gastrointestinal tract
145. The response of cells from low-grade B-cell gastric lymphomas of mucosaassociated lymphoid tissue to Helicobacter pylori
146. Expression of costimulatory molecules in low-grade mucosa-associated lymphoid tissue-type lymphomas in vivo
147. Malignancy in coeliac disease - Effect of a gluten free diet
148. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori
149. Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection
150. Regression of immunoproliferative small intestinal disease after eradication of Helicobacter pylori
151. Salivary gland mucosa-associated lymphoid tissue lymphoma immunoglobulin V(H) genes show frequent use of V1-69 with distinctive CDR3 features
152. Antigen localization regulates immune responses in a dose- and time-dependent fashion: A geographical view of immune reactivity
153. Localization dose and time of antigens determine immune reactivity
154. Integrating innate and adaptive immunity in the whole animal