Lymphoid neo-organogenesis: Lymphotoxin's role in inflammation and development

Immunologic Research

Volumn 19, Issue 2-3, 1999, Pages 119-125

  Ruddle, Nancy H ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autoimmunity; Cytokines; Lymph node development; Lymphotoxin; TNF

Indexed keywords

ADDRESSIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOTOXIN; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

CHRONIC INFLAMMATION; LYMPHOID ORGAN; ORGANOGENESIS; PRIORITY JOURNAL; REVIEW;

EID: 0032806023     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02786481     Document Type: Review

References (35)

1. Picker LJ, Siegelman MH: Lymphoid tissues and organs, in Paul WE (ed.): Fundamental Immunology. New York, Raven Press, 1993. pp. 145-197.
2. Millet I, Ruddle NH: Differential regulation of lymphotoxin (LT), lymphotoxin-β (LT-β), and TNF-α in murine T cell clones activated through the TCR. J Immunol 1994;152:4336-1346.
3. Ferreri NR, Millet I, Askari B, Magnani P, Ruddle NH: Lymphotoxin-β and TNF regulation in T cell subsets: differential effects of PGE2. Cytokine 1997:9:157-165.
4. Ruddle NH, Waksman BH: Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. II Correlation of the in vitro response with skin reactivity. J Exp Med 1968;128: 1255-1265.
5. Ruddle NH, Bergman CM, McGrath KM, Lingenheld EG, Grunnet ML, Padula SJ, et al.: An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis. J Exp Med 1990;172:1193-1200.
6. Santambrogio L, Hochwald GM, Saxena B, Leu CH, Martz JE, Carlino JA, et al.: Studies on the mechanisms by which TGF-β protects against allergic encephalomyelitis: antagonism between TGF-β and TNF J Immunol 1993;151:1116-1127.
7. Selmaj K, Raine CS, Cross AH: Anti-tumor necrosis factor therapy abrogates autoimmune demyelination. Ann Neurol 1991;30:694-700.
8. Powell MB, Mitchell D, Lederman J, Buckmeier J, Zamvil SS, Graham M, et al.: Lymphotoxin and tumor nec-rosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalito-genicity. Int Immunol 1990;2:539-544.
9. Suen WE, Bergman CM, Hjelmstrom P, Ruddle NH: A critical role for lymphotoxin in experimental allergic encephalomyelitis. J Exp Med 1997;186:1233-1240.
10. Cuff CA, Schwartz J, Bergman C, Russell KS, Bender JR, Ruddle NH: Lymphotoxin alpha3 induces chemokines and adhesion molecules: Insight into the role of LT alpha in inflammation and lymphoid organ development. J Immunol 1998;161:6853-6860.
11. Hochman PS, Majeau GR, Mackay F, Browning JL: Proinflammatory responses are efficiently induced by homotrimeric but not heterotrimeric lymphotoxin ligands. J Inflammation 1996:46:220-234.
12. Picarella DE, Kratz A, Li C-b, Ruddle NH, Flavell RA: Transgenic TNF-a production in islets leads to insulitis, not diabetes: Distinct patterns of inflammation in TNF-α and TNF-β transgenic mice. J Immunol 1993;149:4136-4150.
13. Picarella DE, Kratz A, Li C-b, Ruddle NH, Flavell RA: Insulitis in transgenic mice expressing TNF-β (lymphotoxin) in the pancreas. Proc Natl Acad Sci USA 1992;89:10,036-10,040.
14. Kratz A, Campos-Neto A, Hanson MS, Ruddle NH: Chronic inflammation caused by lymphotoxin is lymphoid neogenesis. J Exp Med 1996;183:1461-1472.
15. 2 in lymphotoxin-induced inflammation: Critical role of TNF receptor 1 signaling. J Immunol 1998;160:485-491.
16. Sacca R, Cuff CA, Ruddle NH: Mediators of inflammation. Curr Opinion Immunol 1997;9:851-857.
17. De Togni P, Goellner J, Ruddle NH, Streeter PR, Fick A, Mariathasan S, et al.: Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 1994;264:703-707.
18. Matsumoto M, Mariathasan S, Nahm MH, Baranyay F, Peschon JJ, Chaplin DD: Role of lymphotoxin and the, type I TNF receptor in the formation of germinal centers. Science 1996;271:1289-1291.
19. Koni PA, Sacca R, Lawton P, Browning JL, Ruddle NH, Flavell RA: Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Immunity 1997;6:491-500.
20. Alimzhanov MB, Kuprash DV, Kosco-Vilbois MH, Luz A, Turetskaya RL, Tarakhovsky A, et al.: Abnormal development of secondary lymphoid tissues in lymphotoxin b-deficient mice. Proc Natl Acad Sci USA 1997:94:9302-9307.
21. Marino MW, Dunn A, Grail D, Inglese M, Noguchi Y, Richards E, et al.: Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci 1997;94:8093-8098.
22. Pasparakis M, Alexopoulou L, Epis-kopou V, Kollias G: Immune and inflammatory responses in TNFα-deficient mice: a critical requirement for TNFα in the formation of networks and germinal centers, and in the maturation of humoral immune response. J Exp Med 1996;184:1397-1411.
23. Mebius R, Rennert P, Weissman IL: Developing lymph nodes collect CD4+CD3-LTb+ cells that can differentiate to APC, NK cells, and follicular dells but not T or B cells. Immunity 1997:7:493-504.
24. 3 and LTαβ in inflammation elucidates potential mechanisms of mesentere and peripheral lymph node development. J Immun 1999;162 (in press).
25. Forster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M: A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 1996;87:1037-1047.
26. Ngo VN, Korner H, Gunn MD, Schmidt KN, Riminton DS, Cooper MD, et al.: Lymphotoxin a/b and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J Exp Med 1999:189:403-412.
27. Mooij P, Wit HJD, Drexhage HA: An excess of dietary iodine accelerates the development of a thyroid-associated lymphoid tissue in autoimmune prone BB rats. Clin Immunol Immunopathol 1993;69:189-198.
28. Chilosi, M, Lestani M, Beneditti A, Montagna L, Pedron S, Scarpa A, et al.: Consitutive expression of tenascin in T-dependent zones of human lymphoid tissues. Am J Pathol 1993;143:1348-1355.
29. Ziff M Cavender D: The role of endothelium in chronic inflammation, in Poste G, Crooke ST (eds.): Cellular and Molecular Aspects of Inflammation, New York, Plenum Press, 1988, pp. 57-64.
30. Prineas JW: Multiple sclerosis: Presence of lymphatic capillaries and lymphoid tissue in the brain and spinal cord. Science 1979;203:1123-1125.
31. Raine CS, Cannella B, Duijvestijn AM, Cross AH: Homing to central nervous system vasculature by antigen-specific lymphocytes. II Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination. Lab Invest 1990;63:476-489.
32. Steffen B, Breier G, Butcher EC, Schulz M Engelhardt B: ICAM-1, VCAM-1, and MAdCAM-1 are expressed on choroid plexus epithelium but not endothelium and mediate binding of lymphocytes in vitro. Am J Pathol 1996;148:1819-1838.
33. Hanninen A, Taylor C, Streeter PR, Stark LS, Sarte JM, Shizuru JA, et al.: Vascular addressins are induced on islet vessels during insulitis in nonobese diabetic mice and are involved in lymphoid cell binding to islet endothelium. J Clin Invest 1993;92:2509-2515.
34. Faveeuw C, Gagnerault M-C, Lepault F: Expression of homing and adhesion molecules in infiltrated islets of Langerhans and salivary glands of nonobese diabetic mice. J Immunol 1994;152;5969-5978.
35. Lehmann PV, Sercarz EE, Forsthuber T, Dayan CM, Gammon G: Determinant spreading and the dynamics of the autoimmune T-cell repertoire. Immunol Today 1993;14:203-208.