Histopathology and molecular pathology of synovial B-lymphocytes in rheumatoid arthritis

Histology and Histopathology

Volumn 15, Issue 3, 2000, Pages 791-798

  Krenn, V ^a   Souto Carneiro, M M ^a   Kim, H J ^a   Berek, C ^a   Starostik, P ^a   Konig, A ^a   Harms, H ^a   Muller Hermelink, H K ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Arthritogenic antigens; B cells; Rheumatoid arthritis

Indexed keywords

AUTOANTIBODY; COLLAGEN TYPE 2; FILAGGRIN; HEAT SHOCK PROTEIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MATRIX PROTEIN; MITOCHONDRION ANTIBODY; TETANUS TOXOID;

ANTIGEN ANTIBODY REACTION; B LYMPHOCYTE; CELLULAR DISTRIBUTION; DENDRITE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HYBRIDOMA; INFLAMMATORY INFILTRATE; NONHUMAN; RETICULUM CELL; REVIEW; RHEUMATOID ARTHRITIS; SOMATIC MUTATION; SYNOVIUM;

ANIMALS; ARTHRITIS, RHEUMATOID; AUTOANTIGENS; B-LYMPHOCYTES; CROSS REACTIONS; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; SYNOVIAL MEMBRANE;

BACTERIA (MICROORGANISMS);

EID: 0033913994     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (42)

1. Maturation of the immune response in germinal centers
2. Differences in mutational patterns between rheumatoid factors in health and disease are related to variable heavy chain family and germ-line gene usage
3. Monoreactive and polyreactive rheumatoid factors produced by in vitro EBV transformed peripheral blood and synovial B-lymphocytes from rheumatoid patients
4. Antibody binding to a collagen type 2 epitope gives rise to an inhibitory peptide for autoreactive T cells
5. The dynamic structure of the germinal center
6. The CDR1 sequences of a major proportion of human germline IgvH genes are inherently susceptible to amino acid replacement
7. Recognition of human 60 kD heat shock protein by mononuclear cells from patients with juvenile chronic arthritis
8. Antibodies to the mycobacterial 65-kD heat shock protein are reactive with synovial tissue of adjuvant arthritic rats and patients with rheumatoid arthritis and osteoarthritis
9. Frequencies of autoreactive collagen type II specific B-cells in rheumatoid arthritis
10. Restricted diversity of the variable region nucleotide sequences of the heavy and light chains of a human rheumatoid factor
11. + T cells are associated with younger age of onset in rheumatoid arthritis (RA)
12. Sequence homologies between hsp60 and autoantigens
13. Plasma cell development in synovial germinal centers in patients with rheumatoid and reactive arthritis
14. Organ specific disease provoked by systemic autoimmunity
15. Molecular mimicry between bacterial and self antigne in a patient with systemic lupus erythematosus
16. Immortalized B-lymphocytes from rheumatoid synovial tissue show specificity for bacterial HSP 60
17. Immunohistochemical analysis of proliferating and antigen presenting cells in rheumatoid synovial tissue
18. A novel monospecific IgG2/lambda-autoantibody with specificity for a mitochondrial antigen: Evidence for an antigen-driven pathogenetic B-cell response in rheumatoid suynovial tissue, induced by tissue alteration
19. Mononuclear analysis of rheuma factor (RF)-negative B-cell hybridomas from rheumatoid synovial tissue: Evidence for an antigen-induced stimulation with selection of high mutated IgVH and low mutated IGVL/γgenes
20. Generation and molecular analyses of two rheumatoid synovial fluid-derived IgG rheumatoid factors
21. Germinal centers
22. L anti-class II β-chain antibodies in the serum of synovial fluid of rheumatoid arthritis patients
23. Facultative rolesof germinal centers and T-cells in the somatic diversification of IgVH genes
24. Antineutrophil cytoplasmic antibodies in rheumatoid arthtis. Characterisation and clinical correlations
25. Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response
26. Human monoclonal rheumatoid factors derived from the polyclonal repertoire of rheumatoid synovial tissue: Production and characterization
27. Synovial IgG rheumatoid factors show evidence of an antigen-driven immune response and a shift in the V gene repertoire compared to IgM rheumatoid factors
28. The identification of germinal centers and follicular dendritic cell networks in rheumatoid synovial tissue
29. + B-cells specific for mycobacterial heat-shock protein 60 or human type II collagen in synovial fluid and tissue
30. Differentiation of B cells in the non-lymphoid tissue of the synovial membrane of patients with rheumatoid arthritis
31. The role of clonal selection and somatic mutation in autoimmunity
32. Idiotypic induction of autoimmunity: Do we need an autoantigen?
33. Human synovial B-cell hybridoma from rheumatoid arthritis with specificity for cartilage oligomeric matrix protein (COMP)
34. IgVH genes from different anatomical regions -with different histopathological patterns- of a theumatoid arthritis patient suggest cyclic re-entry of mature synovial B-cells in the hypermutation process
35. Histologie der rheumatoid-arthritis. Beitrag zur diagnostischen und pathogenetischen heterogenitat, zur Aktivitatsdiagnose und prognose
36. The structure and origin of rheumatoid factors
37. Induction of arthritis with monoclonal antibodies to collagen
38. + T-cells in the formation of germinal centers in rheumatoid synovitis
39. On the occurrence of a factor in human serum activating the specific agglutination of sheep corpuscles
40. Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes
41. Specificity of plasma cells in the rheumatoid synovium
42. The immunopathology of joint inflammation in rheumatoid arthritis