The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes

Journal of Experimental Medicine

Volumn 190, Issue 8, 1999, Pages 1183-1188

  Vassileva, Galya ^a   Soto, Hortensia ^a   Zlotnik, Albert ^a   Nakano, Hideki ^b   Kakiuchi, Terutaka ^b   Hedrick, Joseph A ^a   Lira, Sergio A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cell trafficking; Chemokines; Leukocyte chemotaxis; Mutation; T lymphocytes

Indexed keywords

CHEMOKINE;

ANIMAL CELL; ARTICLE; DENDRITIC CELL; GENE DELETION; GENE EXPRESSION REGULATION; GENE TARGETING; IN SITU HYBRIDIZATION; LYMPHOID TISSUE; MEMORY CELL; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION;

ANIMALS; BLOTTING, SOUTHERN; CHEMOKINES; CHEMOKINES, CC; CLONING, MOLECULAR; GENE DELETION; GENE EXPRESSION REGULATION; GENE TARGETING; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; MUTATION; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; T-LYMPHOCYTES;

EID: 0032702638     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.8.1183     Document Type: Article

References (15)

1. Nagira, M., T. Imai, K. Hieshima, J. Kusuda, M. Ridanpaa, S. Takagi, M. Nishimura, M. Kakizaki, H. Nomiyama, and O. Yoshie. 1997. Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13. J. Biol. Chem. 272:19518-19524.
2. Hromas, R., C.H. Kim, M. Klemsz, M. Krathwohl, K. Fife, S. Cooper, C. Schnizlein-Bick, and H.E. Broxmeyer. 1997. Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension. J. Immunol. 159:2554-2558.
3. Tanabe, S., Z. Lu, Y. Luo, E. Quackenbush, M. Berman, L. Collins-Racie, S. Mi, C. Reilly, D. Lo, K. Jacobs, et al. 1997. Identification of a new mouse β-chemokine, thymus-derived cheniotactic agent 4, with activity on T lymphocytes and mesangial cells. J. Immunol. 159:5671-5679.
4. Hedrick, J.A., and A. Zlotnik. 1997. Identification and characterization of a novel beta chemokine containing six conserved cysteines J. Immunol. 159:1589-1593.
5. Willimann, K., D.F. Legler, M. Loetscher, R.S. Roos, M.B. Delgado, I. Clark-Lewis, M. Baggiolini, and B. Moser. 1998. The chemokine SLC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7. Eur. J. Immunol. 28:2025-2034.
6. Gunn, M.D., K. Tangemann, C. Tam, J.G. Cyster, S.D. Rosen, and L.T. Williams. 1998. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. Proc. Natl. Acad. Sci. USA. 95:258-263.
7. Nagira, M., T. Imai, R. Yoshida, S. Takagi, M. Iwasaki, M. Baba, Y. Tabira, J. Akagi, H. Nomiyama, and O. Yoshie. 1998. A lymphocyte-specific CC chemokine, secondary lymphoid tissue chemokine (SLC), is a highly efficient chemoattractant for B cells and activated T cells. Eur. J. Immunol. 28: 1516-1523.
8. Saeki, H., A.M. Moore, M.J. Brown, and S.T. Hwang. 1999. Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes. J. Immunol. 162:2472-2475.
9. Kellermann, S.-A., S. Hudak, E. Oldham, Y.-J. Liu, and L. McEvoy. 1999. The CC chemokine receptor-7 ligands 6Ckine and macrophage inflammatory protein-3 β are potent chemoattractants for in vitro- and in vivo-derived dendritic cells. J. Immunol. 162:3859-3864.
10. Pachynski, R.K., S.W. Wu, M.D. Gunn, and D.J. Erle. 1998. Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAd-CAM-1) under flow. J. Immunol. 161:952-956.
11. Campbell, J.J., J. Hedrick, A. Zlotnik, M.A. Siani, D.A. Thompson, and E.C. Butcher. 1998. Chemokines and the arrest of lymphocytes rolling under flow conditions. Science. 279:381-384.
12. + T cells by Mtv-2 in the DDD mouse. Eur. J. Immunol. 23:2434-2439.
13. Nakano, H., T. Tamura, T. Yoshimoto, H. Yagita, M. Miyasaka, E.C. Butcher, H. Nariuchi, T. Kakiuchi, and A. Matsuzawa. 1997. Genetic defect in T lymphocyte-specific homing into peripheral lymph nodes. Eur. J. Immunol. 27: 215-221.
14. Nakano, H., S. Mori, H. Yonekawa, H. Nariuchi, A. Matsuzawa, and T. Kakiuchi. 1998. A novel mutant gene involved in T-lymphocyte-specific homing into peripheral lymphoid organs on mouse chromosome 4. Blood. 91:2886-2895.
15. Gunn, M.D., S. Kyuwa, C. Tam, T. Kakiuchi, A. Matsuzawa, L.T. Williams, and H. Nakano. 1999. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J. Exp. Med. 189:451-460.