Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr 1a and mdr 1b genes have been disrupted

British Journal of Pharmacology

Volumn 124, Issue 2, 1998, Pages 416-424

  Smit, Johan W ^a,b   Schinkel, Alfred H ^b   Weert, Betty ^a   Meijer, Dirk K F ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Cationic drug elimination; Hepatobiliary and intestinal secretion; P glycoprotein

Indexed keywords

AMPHOPHILE; GLYCOPROTEIN P; PROCAINAMIDE; TRIBUTYLMETHYLAMMONIUM; TRITIUM; VECURONIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG TRANSPORT; DRUG URINE LEVEL; GENE DISRUPTION; HEPATOBILIARY SYSTEM; INTESTINE SECRETION; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL;

EID: 0031837161     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701845     Document Type: Article

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