DNA damage inhibits proteolysis of the B-type cyclin Clb5 in S. cerevisiae

Journal of Cell Science

Volumn 110, Issue 15, 1997, Pages 1813-1820

  Germain, Doris ^a,b   Hendley, Joy ^a   Futcher, Bruce ^b  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b Simons Center for Quantitative Biology   (United States)

Author keywords

Budding yeast; Cyclin; DNA damage; Ubiquitin dependent proteolysis

Indexed keywords

CYCLIN B; CYCLIN DEPENDENT KINASE; FUNGAL DNA; UBIQUITIN;

ARTICLE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DNA DAMAGE; FUNGAL GENETICS; HALF LIFE TIME; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE;

CDC28 PROTEIN KINASE, S CEREVISIAE; CELL CYCLE; CELL CYCLE PROTEINS; CYCLIN B; CYCLINS; DNA DAMAGE; DNA, FUNGAL; FUNGAL PROTEINS; HALF-LIFE; MUTATION; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; S PHASE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EUKARYOTA; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 0030811841     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Al-Khodairy, F., Enoch, T., Hagan, I. M. and Carr, A. N. (1995). The Schizosaccharomyces pombe hus5 gene encodes a ubiquitin conjugating enzyme required for normal mitosis. J. Cell Sci. 108, 475-486.
2. CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae. Nature 355, 368-371.
3. 1 cyclins in the next cycle. Cell 77, 1037-1050.
4. Bai, C., Sen, P., Hofmann, K., Ma, L., Goebl, M., Harper, J. W. and Elledge, S. J. (1996). SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86, 263-274.
5. 1 cyclins in yeast. Nature 384, 279-281.
6. 2 cyclins. EMBO J. 12, 3417-3426.
7. Carr, A. M. and Hoekstra, M. F. (1995). The cellular response to DNA damage. Trends Cell Biol. 5, 32-40.
8. Chen, Z. J., Parent, L. and Maniatis, T. (1996). Site-specific phosphorylation of IκB alpha by a novel ubiquitination-dependent protein kinase activity. Cell 84, 853-862.
9. Clurman, B. E., Sheaff, R. J., Thress, K., Groudine, M. and Roberts, J. M. (1996). Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation. Genes Dev. 10, 1979-1990.
10. 1 cyclin Cln2p by a Cdc34p-dependent pathway. EMBO J. 14, 303-312.
11. Draetta, G., Luca, F., Westendorf, J., Brizuela, L., Ruderman, J. and Beach, D. (1989). cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF. Cell 56, 829-838.
12. Dunphy, W. G. (1994). The decision to enter mitosis. Trends Cell Biol. 4, 202-207.
13. Funabiki, H., Yamano, H., Kumada, K., Nagao, K., Hunt, T. and Yanagida, M. (1996). Cut2 proteolysis required for sister-chromatid separation in fission yeast. Nature 381, 438-441.
14. Glotzer, M., Murray, A. W. and Kirschner, M. W. (1991). Cyclin is degraded by the ubiquitin pathway. Nature 349, 132-138.
15. Hartwell, L. and Weinert, T. (1989). Checkpoints: controls that ensure the order of cell cycle events. Science 246, 629-634.
16. Heichman, K. A. and Roberts, J. M. (1996). The yeast CDC16 and CDC27 genes restrict DNA replication to once per cell cycle. Cell 85, 39-48.
17. Hochstrasser, M. (1995). Ubiquitin, proteasomes, and the regulation of intracellular protein degradation. Curr. Opinion Cell Biol. 7, 215-223.
18. Holloway, S. L., Glotzer, M., King, R. W. and Murray, A. W. (1993). Anaphase is initiated by proteolysis rather than by inactivation of maturation promoting factor. Cell 73, 1393-1402.
19. Irniger, S., Piatti, S., Michaelis, C. and Nasmyth, K. (1995). Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. Cell 81, 269-277.
20. 2 arrest in human cells. J. Cell Biol. 134, 963-970.
21. cdc2. Cancer Res. 54, 1412-1414.
22. King, R. W., Peters, J., Tugendreich, S., Rolfe, M., Hieter, P. and Krischner, M. (1995). A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 81, 279-288.
23. 1 cyclin Cln2 induced by CDK-dependent phosphorylation. Science 271, 1597-1600.
24. Lew, D. J. and Reed, S. I. (1995). A cell cycle checkpoint monitors cell morphogenesis in budding yeast. J. Cell Biol. 129, 739-749.
25. Lim, H. H., Goh, P.-Y. and Surana, U. (1996). Spindle pole body separation in Saccharomyces cerevisiae requires dephosphorylation of the tyrosine 19 residue of Cdc28. Mol. Cell. Biol. 16, 6385-6397.
26. Murray, A. W., Solomon, M. J. and Kirschner, M. W. (1989). The role of cyclin synthesis and degradation in the control of maturation promoting factor activity. Nature 339, 280-286.
27. Murray, A. (1995). Cyclin ubiquitination: the destructive end of mitosis. Cell 81, 149-152.
28. Nugroho, T. T. and Mendenhall, M. D. (1994). An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells. Mol. Cell. Biol. 14, 3320-3328.
29. 2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation. EMBO J. 16, 545-554.
30. Peters, G. (1994). Stifled by inhibitors. Nature 371, 204-205.
31. Russell, P., Moreno, S. and Reed, S. (1989). Conservation of mitotic controls in fission and budding yeasts. Cell 57, 295-303.
32. Sanchez, Y., Desany, B. A., Jones, W. J., Liu, Q., Wang, B. and Elledge, S. J. (1996). Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271, 357-360.
33. Schneider, B. L., Yang, Q. H. and Futcher, A. B. (1996). Linkage of replication to start by the Cdk inhibitor Sic 1. Science 272, 560-562.
34. 1 to S transition in Saccharomyces cerevisiae. Cell 79, 233-244.
35. Seufert, W., Futcher, B. and Jentsch, S. (1995). Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins. Nature 373, 78-81.
36. cdc28. Nature 355, 365-368.
37. Stepanova, L., Leng, X., Parker, S. B. and Harper, J. W. (1996). Mammalian p50-cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. Genes Dev. 10, 1491-1502.
38. Surana, U., Amon, A., Dowzer, C., McGrew, J., Byers, B. and Nasmyth, K. (1993). Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast. EMBO J. 12, 1969-1978.
39. 1 arrest induced by ultraviolet irradiation. Nature 376, 358-362.
40. Tugendreich, S., Tomkiel, J., Earnshaw, W. and Heiter, P. (1995). CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. Cell 81, 261-268.
41. Tyers, M., Tokiwa, G., Nash, R. and Futcher, B. (1992). The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation. EMBO J. 11, 1773-1784.
42. 1 cyclins - CLN3 may be an upstream activator of CLN1, CLN2 and other cyclins. EMBO J. 12, 1955-1968.
43. Walworth, N., Davey, S. and Beach, D. (1993). Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature 363, 368-371.
44. Walworth, N. C. and Bernards, R. (1996). Rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint. Science 271, 353-356.
45. Weinert, T. A., Kiser, G. L. and Hartwell, L. H. (1994). Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev. 8, 652-665.
46. Won, K.-A. and Reed, S. I. (1996). Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependant degradation of cyclin E. EMBO J. 15, 4182-4193.
47. CDC28-dependent phosphorylation of the cyclin Cln3 that signals its degradation. Mol. Cell. Biol. 16, 3679-3684.
48. Yamamoto, A., Guacci, V. and Koshland, D. (1996). Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s). J. Cell Biol. 133, 99-110.
49. cdc2 in Aspergillus nidulans. EMBO J. 16, 182-192.